Francesca Zappa

Senior Scientist @AltosLabs studying intra and inter-cellular mechanisms downstream of stress signaling. Membrane trafficking aficionado || Proud mum of three

[Alison Forrester @AlisonForreste3]

Had an awesome time at the Awesome Lysosome Meeting @Tigem_Telethon! Celebrating 30 years of TIGEM and Andrea Ballabio stepping down from role as director. Caught up with old friends and made lots of new (and VERY new!) friends! @franzappa2 @cristinasorr

[Cell Biology J-Club @cell_club]

A size filter at the Golgi regulates apical membrane protein sorting
https://t.co/oeCGNsLNMU

[Francesca Zappa @Frances43977343]

Thank you @ASCBiology for the highlights!

[American Society for Cell Biology @ASCBiology]

From MBoC
How is ER integrity maintained during cell division? @Frances43977343 latest study reveals how Unfolded Protein Response baseline signaling influences cell division dynamics. Dive into organelle inheritance & cell... #UPR #ISR #PERK #CellCycle

https://t.co/2mR8plwFkL

[American Society for Cell Biology @ASCBiology]

From MBoC
How is ER integrity maintained during cell division? @Frances43977343 latest study reveals how Unfolded Protein Response baseline signaling influences cell division dynamics. Dive into organelle inheritance & cell... #UPR #ISR #PERK #CellCycle

https://t.co/2mR8plwFkL

[Francesca Zappa @Frances43977343]

mTOR activation induces endolysosomal remodeling and unconventional secretion of IL-32 via exosomes in inflammatory reactive astrocytes | bioRxiv https://t.co/j821qHt0kY

[News from Science @NewsfromScience]

New data released by the U.S. National Science Foundation underscore concerns that the academic community is facing a postdoc shortage and that early-career scientists are increasingly favoring higher paid positions outside academia. @ScienceCareers https://t.co/Xu9t7BN0f9

[Francesca Zappa @Frances43977343]

@ishier_raote @hannes_maib @felixmendu @Fran_Bottanelli @Team_FranckP Are these recorded? Asking for a friend that lives in the other hemisphere

[Cell Biology J-Club @cell_club]

Syntaxin 17 recruitment to mature autophagosomes is temporally regulated by PI4P accumulation https://t.co/lT0OCcvyFx

[BökeLab @LabBoke]

1/ 📢New #paper alert! Ever wondered how mammalian #oocytes deal with protein #aggregation during their prolonged #life? Check it out in our new paper led by @zaffagg3 out today in @CellCellPress: https://t.co/mH7Hcb41is
👇🏽a thread:

[Samuel Hume @DrSamuelBHume]

Women are 4-times more likely to have autoimmune diseases than men. Why is this?

From Dou et al. in Cell, today

In females, the second X chromosome is silenced by a long non-coding RNA, called Xist (pronounced 'exist') - males don't express Xist

Xist, together with almost 100 unique proteins, wraps itself around the second X chromosome, silencing it. It's thought that Xist-protein complexes are highly immunogenic, and may represent targets for autoantibodies

Dou et al. devised a system to induce expression of Xist in male mice. They found that Xist expression led to the production of autoantibodies, similar to levels found in female mice (RIBO P0/P2 are lupus autoantibodies, CENPA/B are scleroderma autoantibodies):
In a mouse model, these autoantibodies in Xist-expressing males were sufficient to cause significant lupus pathology (including in the kidney and the lung):
In humans, autoantibodies against the Xist ribonucleoprotein complex were enriched in female patients with lupus, scleroderma, and dermatomyositis

Therefore, Xist may solve the puzzle of female-biased autoimmunity

https://t.co/95sqEMGqJ8

[Francesca Zappa @Frances43977343]

Great viewpoint from scientists and my stellar friend @mc_masone about the often underrated challenges of being a non-native English in science.
Most of us can relate!

[Nature Reviews Urology @NatRevUrol]

In this great Viewpoint, academics, clinicians, and editors discuss the challenges and opportunities of being non-native English speakers in science and medicine @SigridCarlsson Sandro Esteves @elijeandin @MariaJRibal @yao_zhu_sh @mc_masone Read it here: https://t.co/WwXqWl4oNA

[Nature Reviews Urology @NatRevUrol]

In this great Viewpoint, academics, clinicians, and editors discuss the challenges and opportunities of being non-native English speakers in science and medicine @SigridCarlsson Sandro Esteves @elijeandin @MariaJRibal @yao_zhu_sh @mc_masone Read it here: https://t.co/WwXqWl4oNA

[Nature Biotechnology @NatureBiotech]

Control of mammalian gene expression by modulation of polyA signal cleavage at 5′ UTR https://t.co/Sk9UD9X7ey

[Cell Reports @CellReports]

Impact of eIF2α phosphorylation on the translational landscape of mouse embryonic stem cells https://t.co/RB4ob2bFtq

[Cell Biology J-Club @cell_club]

Congress of multiple dimers is needed for cross-phosphorylation of IRE1α and its RNase activity https://t.co/MK9sR2dGoW

[Cell Reports @CellReports]

Sequestration of translation initiation factors in p62 condensates https://t.co/glcggnY1Zw

[Jarod Rutledge @JarodRutledge1]

I’m proud to share my new research in @Nature this week, co-led by @hammy_oh, where we develop blood tests to track how your organs age! “But Jarod, why should I care? What can we really do with this?” Here are 3 ways we think this will be useful in science and medicine! 1/10

[Cell Biology J-Club @cell_club]

Nutrient deprivation alters the rate of COPII subunit recruitment at ER subdomains to tune secretory protein transport
https://t.co/lOIDOqg8tA

[Francesca Zappa @Frances43977343]

@mcboone and my view of the ISR, a fascinating stress signaling network https://t.co/S29uz4ZwQf
I hope you’ll enjoy the reading as much as we enjoyed the writing!

[Cell Biology J-Club @cell_club]

Coordination of RAB-8 and RAB-11 during unconventional protein secretion https://t.co/LHcrxpWqzf