*Left: acute erythroid leukemia (formerly pure erythroid leukemia) nearly always shows bi-allelic loss of TP53
*Right: acute megakaryoblastic leukemia, variable genetics.
Among the most aggressive forms of AML 💀
*Both resistant to venetoclax
#hemepath#leusm
https://t.co/Tyb55uaHSd - Day 5
Hassall's corpuscles are unique to the thymus and consist of clusters of epithelial reticular cells found in the medulla. They are thought to be involved in the maturation and selection of T lymphocytes.
#Histology#PathX#Pathresessentials
Reading a bit of Molavi’s Practice of Surgical Pathology every day so I can finish by July. I used to annotate images and diagrams like this on my iPad all the time as 1st year med student - what a throwback! Today: LSIL and HSIL
I hate #cancer
I have lost close family members to cancer and have several loved ones who are learning to live with this diagnosis.
Watching #PrincessKate having to disclose this very private and difficult journey to an insanely speculative and nosy world was heart wrenching and I wish her health and a speedy recovery 🙏🏾
It also highlighted why I was motivated to become a #pathologist - there is a #pathology physician in Kate’s medical team that provided that definitive, final diagnosis that may not have even been suspected prior to her surgery.
The pathologist reviewed her tissue at the cellular (and possibly molecular) level and gave that final answer. The information from the pathology lab establishes the diagnosis and the prognosis (and later on the confirmation of remission) for all cancers.
In my case it was my grandma’s cancer diagnosis that made me wonder about the mystery behind the diagnosis and sowed a seed to consider this diagnostic medical specialty.
Thank you, Princess Kate, for your bravery and grace
#Path2Path #TheRoyalDiagnosis #medicalstudentX @RoyalFamily@KensingtonRoyal
https://t.co/Tyb55uaHSd - Day 4
I struggled with promyelocytes vs myelocytes during my #hemepath rotation. Importantly, promyelocytes have only primary (azurophilic) granules while myelocytes also have secondary (specific) granules. What are the numbered cells below? #PathX
Pautrier microabscesses may be a distinguishing feature of cutaneous T cell lymphoma (CTCL). CTCL mimics other dermatoses. Clinical correlation, IHC, and molecular testing may be required for optimal diagnosis and management.
#hemepath#dermpath@GIJamesMD@KZhuPath@PathJared
Metastatic breast carcinoma to the bladder can mimic urothelial carcinoma. As with all secondary tumors, it is critical to have a high level of clinical suspicion and do the markers. Morphologic clue: tumor under normal urothelium, no CIS or papillary structures. #gupath
https://t.co/Tyb55uaHSd - Day 3 (after match day hiatus)
Two types of bone for two different functions. Form determines function!
#PathX#Pathresessentials#path2path
I am a benign vascular lesion
I have associated epidermal hyperplasia
I may be solitary or multiple and the latter may be associated with Fabry disease (X linked lysosomal disorder affecting alpha-galactosidase A)
Who am I?
#pathagonia#pathx#dermpath#dermatology#medx#peds