We report many proteins not predicted by the genetic code.
They are stable & abundant O( 10³ ) copies / cell.
Generative mechanisms include codon-anticodon mismatches & RNA modifications.
Their abundance depends on codon frequency & protein stability.
https://t.co/lAxvulC4zx
Nejraději byste se rozdali? 🤗 To není nutné, k dobrému skutku v podobě zlepšení nebo záchrany něčího života stačí ze sebe darovat jen malý kousek – třeba trochu krve. 🩸
Při dnešním Světovém dni dárců krve se proto se Samuelem ubezpečíme, že nás tím rozhodně neubyde. 💁♂️
Finally, out!
MFSD1 functions as a general dipeptide uniporter in lysosomes!
This was a real team effort. Many thanks to @Kathaschnatta, @DammeMarkus, @OceaneGuelle and Bruno Gasnier, @AhmadRezaMehdi1, @abu_remaileh, and everyone else involved!
See: https://t.co/ltklnR3Rp6
@SiFuJasper@BGatesIsaPyscho No he didn’t, he is a corrupt populist resposnible for establishment of mafia state in Slovakia. Nevertheless, I condemn the violence, that is obviously not acceptable.
We're looking for a postdoc and an RA to join us @ucl! Interested in how the #malaria parasite adapts its cytoskeleton for disease transmission? Join our @wellcometrust funded project and use #insitu#CryoET to study parasites! DM or email any questions. Links in the comments.
@dschweppe1 This offers some really useful insights into CETSA/PISA! I might have lost the information in all the figures: among the detected targets, is there a correlation between significant thermal stabilization and protein coverage/no. of unique peptides?
This is the reality that MIT President wants to hide. A letter from Israeli & Jewish MIT students:
To all students at MIT,
Today, Jewish and Israeli MIT students were physically prevented from attending class by a hostile group of pro-Hamas and anti-Israel MIT students that call themselves the CAA.
This is after students from the CAA harassed MIT staff members in their offices for being Jewish and interrupted classes in the past few weeks. All of this has occurred with no clear response from the administration. With each passing day, MIT admin’s silence makes Jewish and Israeli students feel unsafe at MIT.
Many Jewish students fear leaving their dorm rooms and have stated that they feel MIT is not safe for Jews. This message is compounded by the public and private warnings of Hillel and many faculty that Jewish students should not enter MIT’s main lobby today, November 9th, 2023.
Instead of dispersing the mob or de-escalating the situation by rerouting all students from Lobby 7, Jewish students specifically were warned not to enter MIT’s front entrance due to a risk to their physical safety. The onus to protect Jewish students should not be on the students themselves.
MIT administration recently announced guidelines to avoid illegal and unsafe protests on campus. The CAA, which planned the protest, knowingly and proudly violated these requirements, and even invited people from outside of MIT to join them. Their actions inhibit the possibility of safe and peaceful dialogue and endanger Jewish students on campus.
The CAA hosted a blockade that not only disregards MIT guidelines, but also obstructs Jewish students from attending classes.
Some Jewish students who saw the administration’s failure to respond to the targeted harassment of Jews on campus by the CAA came together to support each other and peacefully together stand against this threat to their safety.
Four hours after the blockade started, at 12 pm, the MIT administration passed a letter to all students, threatening their suspension if the crowds did not disperse from Lobby 7. Only the Jewish students left immediately. The CAA protesters did not cooperate. Indeed, the CAA proceeded to invite more students and non-MIT protestors to join them in calling for a violent uprising (“Intifada”) and justifying the terror attacks of Hamas on Israeli civilians.
At 5 pm, all students on campus were warned through MIT’s emergency notification system to “avoid Lobby 7” –– officially recognizing the danger present to students as a result of this violent protest. No Jewish or Israeli students were present at this point.
As of 10:30 tonight MIT has officially decided not to academically suspend CAA students who repeatedly violated the administration's guidelines and threats. They have shown that actions against Jews at MIT do not have consequences. Additionally, in an email to DUSP students, the Department Head indicated that he would protect any DUSP students involved in violating MIT’s rules today by protesting with the CAA. Not only do Jewish students feel unsafe on campus, but now they also feel excluded from and unsafe in DUSP.
Today, on the 9th of November, on the 85th anniversary of Kristallnacht, which marked the beginning of the Holocaust, Jews at MIT were told to enter campus from back entrances and not to stay in Hillel for fear of their physical safety.
We are seeing history repeating itself and Jews on MIT’s campus are afraid.
Signed,
The MIT Israel Alliance and its supporters
Left: How the UN General Assembly voted for a humanitarian truce in Gaza.
This is the final vote being spun to claim abstaining countries - like the Baltics and Ukraine, for example - didn’t support a humanitarian truce.
Right: How the UN General Assembly voted on the exact same resolution - yet with the added statement that the UN General Assembly “unequivocally rejects and condemns the terrorist attacks by Hamas that took place in Israel starting on the 7th of October 2023 and the taking of hostages, demands the safety, well-being and humane treatment of the hostages in compliance with international law, and calls for their immediate and unconditional release".
That amendment got a majority of global votes, but didn’t pass to a final vote because it needed a two thirds majority.
It was blocked by a minority of countries that wanted to remove condemnation of hamas and specifically didn’t like the term “hostages” (rather than “captives”) because it recognises them as a criminal group.
As a result of this geopolitical gameplaying at the expense of Palestinians, the final vote was polarising in the way it could legitimise a terrorist organisation holding hostages.
This is why countries chose to abstain on the final vote.
Thanks again to #mpm2023 organisers for giving me the opportunity to present my work on #malaria#complexome! The amount of feedback and inspiration from the community will definitely keep me busy for the next couple of months 😅
Nervous but also excited to be the first speaker at the opening plenary session at #mpm2023 ! Don’t be late for my talk on the dynamic universe of protein complexes in malaria parasites!
I was surprised to discover that my whole family and I have all been banned by British police from attending this weekend's BAFTA awards where the documentary #Navalny is nominated. The reason stated: we "represent a public security risk". (1/3)