Phage Network Copenhagen

A society of phage researchers located in Copenhagen and the south of Sweden. Here we will post events and participate in the dissemination of phage knowledge.

[Patrick R. Secor @PRSecor]

More BIG NEWS 🚨

I am super excited to share that my lab has relocated to the Dept of Microbiology & Cell Biology @MSU_MicroImmuno at @montanastate in Bozeman, MT.

We will be looking to recruit scientists at all levels. Get in touch if you love phages, microbes, & mountains.

[The Phage @The_Phage_xyz]

tax_myPHAGE, a script for classifying your double-stranded DNA phages. It assignin taxonomy to phages at the genus and species levels following ICTV standards. Determines the closest relatives of a query within the ICTV-classified genomes. https://t.co/B9zbzS9BOM

[soeding_lab @SoedingL]

PenguiN, our viral metagenomics assembler, just got accepted at BMC Microbiome!
In contrast to the standard de Bruijn graphs assemblers, it uses all-vs-all alignment in linear time to merge reads. This allows it to often resolve severalfold more strains than dBG assemblers.

[Phage Network Copenhagen @PhageNetworkCPH]

Thanks to all of you joined, raised questions and made this afternoon very enjoyable!!

Hope we soon be able to this again.

[Phage Network Copenhagen @PhageNetworkCPH]

The second one

Retron-Eco1 assembles NAD+-hydrolyzing filaments that provide immunity against phages
https://t.co/cGjNf3eW88

This retron RT produce multiple ssDNA pieces essential for trapping a NAD+ hydrolysing toxin, which is then released upon phage entry.

[Phage Network Copenhagen @PhageNetworkCPH]

For the grand finale, Feußner explained how the phage aca2 works on both transcriptional level but also on the posttranscriptional level via stem loops in the 5’-end.

Phage anti-CRISPR control by an RNA- and DNA-binding helix–turn–helix protein
https://t.co/49g4aQwGPc

[Phage Network Copenhagen @PhageNetworkCPH]

All three studies are available:

The first one
Structure and mechanism of Zorya anti-phage defense system
https://t.co/6CtjY8An91

The membrane associated ZorAB bears resemblance to the rotary flagella motor and is able to sense cell envelope damage -> recruit ZorC and -D

[Phage Network Copenhagen @PhageNetworkCPH]

First @NMITaylorLab explained how the Zorya defence is assembled upon phage entry, then @rafapinilla92 explained how retron filaments cage and release effectors, before Maximilian Feußner took us through fine-tuned regulation of anti-CRISPRs!

[Phage Network Copenhagen @PhageNetworkCPH]

It has been a while since we posted. But in context of Maximilian Feußners visit in Copenhagen we held a seminar on phage defences.
For this we had 3 wonderful talks which is highlighted in a 🧵 below.

[Phage Network Copenhagen @PhageNetworkCPH]

@gaygirlinalep @bentpetersen @TSPKU @Globe_UCPH Hi, no unfortunately this event is planned as in-person. If it gets recorded though, we will let you know.

[Phage Network Copenhagen @PhageNetworkCPH]

We are very pleased to announce the next event in our network. The 23rd of February @bentpetersen and @TSPKU will introduce their work on computational biodiscoveries at @Globe_UCPH . More info and sign up at https://t.co/rxkiExdFdJ

[Phage Network Copenhagen @PhageNetworkCPH]

We hope to see many known and new faces for this intriguing line-up :)

[Phage Network Copenhagen @PhageNetworkCPH]

On Thursday (the 31st) there will be 4 interesting lectures on phage-host interactions at Aud. A (Universitetsparken 15). Everyone is welcome!

[Phage Network Copenhagen @PhageNetworkCPH]

Finally at 1 PM, the day will end with Sarah Camara defending her PhD thesis, which is entitled CRISPR-Cas repurposed: Defense and counter-defense on mobile genetic elements.

[Gemma C Atkinson @gem__atkinson]

Also, an early heads up that I’ll be advertising a bioinformatics PhD position on phage defence (what else?!) in the coming weeks.

[Vasili Hauryliuk @hauryliuk]

Anybody interested in joining us in Lund? Many antiphage projects, wet lab with me or dry lab with @gem__atkinson - or combine both? And you can freeze some cryo-EM grids in our corridor if you wish to...

[Dr. Melanie Blokesch @MBlokesch]

Reminder: it's still possible to apply for GRC (&GRS) Microbial Adhesion and Signal transduction for this July in beautiful Newport, RI (filling up quickly!).
To be considered as participant, don't forget to add an abstract. Going to be a great meeting 🤩
https://t.co/B6jPgVAxeg

[Phage Directory @phagedirectory]

In a new preprint, @phagemuffin (@UniBasel_en) etal describe a #phage, able to kill dormant, antibiotic-tolerant bacteria. They suggest this phage hijacks weak spots that could be exploited for the development of new treatments against resilient bacteria https://t.co/qAR2wstEJM

[Phage Network Copenhagen @PhageNetworkCPH]

@NinaMolinHK We are always open for suggestions, and believe that is a great one Nina. We will for sure have that in mind for the future planning.

[Phage Network Copenhagen @PhageNetworkCPH]

Thanks to all of you attending the first @PhageNetworkCPH seminar yesterday! And of course thanks to @rayenleonq and @RhoyStarkiller for introducing the fascinating world of filamentous phages and PICIs :)