Philip Lab

Working together at the frontier of cancer and immunology to advance cancer care, science, and education

[Philip Lab @philiplabvandy]

And a big thank you and shout out to @EricSkaar @kh_oliver @VI4Research @bwfund for creating and supporting this great program to bring scientists and artists together!

[Philip Lab @philiplabvandy]

Check out VUMC reporter piece on @jjroetman @CIR_AACR paper featuring amazing artwork by senior Halle Borowski @williamandmary created during the @ArtLab_Vandy @VI4Research Summer 2023 program!
https://t.co/4Hm780toMw

[Philip Lab @philiplabvandy]

Check out other @artlab_vandy art at the Vanderbilt Fine Arts Gallery
https://t.co/vlsWEYZiZm

[Philip Lab @philiplabvandy]

We welcome feedback and suggestions, and a big thank you to our colleagues
@VUMC_VCI @VUMC_Cancer @VUMCDIsoveries @Vandy_Biomed
for all their support! 7/7

[Philip Lab @philiplabvandy]

Happy to present our latest paper in @CIR_AACR from @jjroetman, the whole @philiplabvandy team and Drs. Youngmin Lee and Ting-Fang Less @VUMCSurgery !

[Cancer Immunology Research @CIR_AACR]

#OnlineFirst: Tumor-reactive CD8+ #Tcells enter a TCF1+PD1– dysfunctional state, by @jjroetman, Mary Philip et al.
https://t.co/yy9dJEEjUi
@immuno_minna @VUmedicine

[Philip Lab @philiplabvandy]

We hypothesize that peptide/MHC-TCR affinity may play a role in the divergent antigen-dependent differentiation we observed as self-shared antigens are usually lower affinity. 6/7

[Philip Lab @philiplabvandy]

Immune checkpoint blockade (ICB) can unleash T cell responses against tumors but can also cause unwanted toxicity, or immune-related adverse events (irAE), when T cells attack self/shared antigens in non-cancerous tissues. 3/7

[Philip Lab @philiplabvandy]

@jjroetman developed a unique cancer model in which we could study CD8 T cell responses against tumor-specific antigens and self/shared antigens. 2/7

[Philip Lab @philiplabvandy]

Happy Halloween🎃🎃🎃from the Dr. Seuss Lab @VUMC_VCI @VUmedicine @VanderbiltU

[Philip Lab @philiplabvandy]

Congratulations @JeffRathmell @ahasty4 @hasty4 @MakowskiLab @WellenLab! @VUMC_Cancer @VUMC_VCI

[The Mark Foundation for Cancer Research @TheMarkFdn]

Congratulations Endeavor team at Vanderbilt, University of Tennessee, University of Pennsylvania: Jeffrey Rathmell, Alyssa Hasty, Liza Makowski, Kathryn Wellen @jeffrathmell @hasty4 @MakowskiLab @WellenLab @vumc_cancer @PennMedicine

[Philip Lab @philiplabvandy]

@JeffRathmell @KimrynRathmell @americanacad Congratulations @KimrynRathmell! A well-deserved honor for a great physician-scientist, Chair @VUMC_Medicine and role model!

[Philip Lab @philiplabvandy]

Congratulations Andrea!

[The American Association of Immunologists (AAI) @ImmunologyAAI]

Congratulations to Dr. Andrea Schietinger, who received the AACR-Irving Weinstein Foundation Distinguished Lectureship. https://t.co/XNQWARoPMx #Immunology

[Philip Lab @philiplabvandy]

@JeffRathmell @AmyMajor6 Congratulations Brenna and @AmyMajor6!

[Philip Lab @philiplabvandy]

@acerobed @VUMC_VCI @VUMC_Cancer @JeffRathmell @SchietingerLab We found that E-TAG show evidence of greater inflammation-driven TF (IRFs and STATs, Fig. 5e shows nice TF motif analysis by Paul Zumbo @DBetel), which may induce functional differentiation in E-TAG. There are likely other factors, and we're working is to figure those out.

[Philip Lab @philiplabvandy]

We are excited to share our work published today in @NatImmunol by @MRudloffMSTP, the whole @PhilipLabVandy team @VUMCDiscoveries, and in collaboration with our fantastic computational biology collaborators @dbetel and his group @WeillCornell. 1/7
https://t.co/zaXpn9sF91

[Philip Lab @philiplabvandy]

@acerobed @VUMC_VCI @VUMC_Cancer @JeffRathmell @SchietingerLab The E-TCRTAG were TAG-specific CD8 T cells in Listeria-infected mice, and as these T cells gain effector function, we abbreviated them as E-TCRTAG. The T-TCRTAG are TAG-specific T cells in tumor-bearing mice, and these become dysfunctional.