Philipp Keller

PostDoc in the Vorholt group @Microbio @ETH_en.
Enabling bioprocesses via methanol.
Fascinated about #metabolism, #syntheticbiology and #evolution.

[Andreas Keppler @andreaskeppler]

Thrilled to finally share!
The plant microbiota triggers dose-dependent immune responses that feed back to influence bacterial colonization. This affects non-pathogenic and pathogenic strains, impacting microbiota homeostasis.

Out today in @NaturePlants: https://t.co/qbEgwK3oRI

[Jethro Hemmann @JethroHemmann]

Exciting news! 🤩 I will start a research group @LeibnizHKI next year!

We will investigate (antimicrobial) natural products involved in interactions in the moss microbiome – a promising but so far understudied habitat 🌱🧫

Funded by @tmwwdg, @EU_Sozialfonds Plus, @aufbaubank 🙏

[ETH Zurich @ETH_en]

ETH researchers have developed bacteria that efficiently utilize methanol, offering a sustainable alternative to producing valuable products currently derived from fossil fuels. 🛢️ @ETH_DBIOL #FossilFuels #ClimateNeutral https://t.co/px16ummfuC

[Philipp Keller @PhilippPk]

@mRetier @TomGassler @TimothyBra91929

[Philipp Keller @PhilippPk]

Towards a #circulareconomy !
Here, we show the production of 4 chemicals from different metabolic nodes and highlight the potential of our synthetic methylotrophic E. coli.

Thanks to everyone that was evolved!;) It was a great team effort! @ETH_en

https://t.co/PiYJIGyPWY

[Michael Reiter @mRetier]

Recently, @PhilippPk & I developed a synthetic methylotroph in the Vorholt lab to convert green methanol to carbon-negative chemicals. Thrilled to share that we now received the SNF/Innosuisse BRIDGE Discovery grant to support translating our tech to industry. #climateChange

[Michael Reiter @mRetier]

💻We just updated Dashing Growth Curves with additional features and improved performance.
🦠If you’re looking for an easy-to-use tool for rapid analysis of microbial growth check out https://t.co/c3XiUVATDZ

[Andreas Keppler @andreaskeppler]

https://t.co/6YllcqAzFw

[Jethro Hemmann @JethroHemmann]

Exciting preprint by the lab of @CeciMGLab!

They describe the discovery and structure of "methylolanthanin", a metal chelator secreted by Methylobacterium for the uptake of lanthanides!

[D-BIOL @ ETH Zurich @ETH_DBIOL]

Predicting interactions in plant microbiomes made possible. Metabolic modelling sheds light on bacterial interactions in planta, see the recent work by Vorholt Lab @ETH_en and @realLCSB at EPFL. More: https://t.co/hzWV3ogfjp

[Piel Lab @piel_lab]

Check out our new story on TyrEx Cycloaddition on enzymatic generation of dienophiles in bacteria and how to use these for protein conjugation, now out in @NatureChemistry! Great work from @EdgarsLakis and @danirichterfl at @piel_lab.

https://t.co/ABBacOOvBu

[Birgitta Ryback @BirgittaRyback]

Last PhD study is out in @jbiolchem ! We probed coenzyme metabolism by adding vitamins to culture media. It was fun to do, and it turns out one of the vitamins goes through a degradation-reconstitution cycle previously unidentified.

https://t.co/OrsBQr4iyy

[Microbiology_ETH @Microbio_ETH]

Congratulations to Chantal Ernst and @GabrielGiger from the #VorholtLab, who both received the best short talk award at the #EESSymbiosis!

[@vardilab @vardilab]

Excited to share our latest work, led by Noa Barak-Gavish, showing how opportunistic bacteria modulate their lifestyle from coexistence to pathogenicity by perceiving the physiological state of their algal host through sensing of algal secreted metabolites https://t.co/GkYnVMRFV3

[Philipp Keller @PhilippPk]

Thank you @JethroHemmann and the other collaborators for the great team effort!!

[Philipp Keller @PhilippPk]

Did you know that rare-earth elements are utilized by some bacteria?🦠😍
In this paper @jbiolchem, we describe the lanthanide response of the methylotroph Methylobacillus flagellatus and the discovery of lanpepsy, a novel lanthanide-binding protein.🤗
https://t.co/mL9i7hXwQ8

[Michael Reiter @mRetier]

New tool for everyone studying microbial growth! After one too many tedious sessions analyzing growth curves in Excel or Python, I decided to build a better solution. Dashing Growth Curves https://t.co/QoY79hpGpR is an easy-to-use web app that accelerates growth curve analysis👇

[Philipp Keller @PhilippPk]

New tool for studying microbial growth! My co-worker
@mRetier created an online tool to quickly analysis growth curves from hundreds of samples. This can save you a lot of time! Check it out here: https://t.co/tHtn00YH09

[Philipp Keller @PhilippPk]

@BirgittaRyback @mRetier @TomGassler @NatureComms Thank you @BirgittaRyback

[Philipp Keller @PhilippPk]

Towards the methanol economy! We turned the biotech workhorse E. coli into an organism that can just live on methanol! Tremendously enjoyed the team effort @mRetier @TomGassler and everyone else involved! @NatureComms

https://t.co/lU8bPyZAqQ

[Philipp Keller @PhilippPk]

Thank you @JethroHemmann

[Jethro Hemmann @JethroHemmann]

E. coli can also grow on methanol as the sole source of carbon! 🤩 Nice paper from colleagues at the Vorholt lab @Microbio_ETH where they engineered and evolved an E. coli strain into a methylotroph: https://t.co/h7yzjssDc4