Pita Segura

Postdoc in Tajima’s lab, really enthusiastic of ion channels and receptors .

[Pita Segura @PittaSegura]

Excited to share our new paper in Science Advances! We combined cryo-EM and electrophysiology to uncover how GluK2/GluK5 kainate receptor subunits differentially shape receptor gating and pharmacological modulation.

https://t.co/0Ysro89APk

[Journal of General Physiology @JGenPhysiol]

GRIN2B disease-associated mutations disrupt the function of BK channels and NMDA receptor signaling nanodomains, say Rebeca Martínez-Lázaro, David Bartolomé-Martín, Teresa Giraldez et al. @ULL https://t.co/B0VwfCTMix

#Biophysics #Pathophysiology #IonChannels

[Pita Segura @PittaSegura]

Excited to share our latest study in #NatureStructMolBiol @NatureSMB
We reveal how partial agonist domoate activates the GluK2 Kainate receptor, highlighting the role of N-glycans in modulating gating mechanisms. Huge thanks to everyone who supported this journey.

[NatureStructMolBiol @NatureSMB]

New online! Structural basis of GluK2 kainate receptor activation by a partial agonist https://t.co/p65YvQEGvf

[NatureStructMolBiol @NatureSMB]

New online! Structural basis of GluK2 kainate receptor activation by a partial agonist https://t.co/p65YvQEGvf

[Membrane Protein PDB @MemProtPDB]

Mechanisms underlying modulation of human GlyRα3 receptors by Zn2+ and pH | Science Advances

https://t.co/c61xlryaDm

[Journal of General Physiology @JGenPhysiol]

Regulation of NMDAR activation efficiency by environmental factors and subunit composition. New study from Miaomiao He (@Miaomiao_He_) and Lonnie Wollmuth (@LonnieWollmuth) @stonybrooku: https://t.co/7Ewv6LBk1q

#MolecularPhysiology

[Alexander Sobolevsky @AlexanderSobol6]

Structures of GluK2 kainate receptor in complex with spermine and polyamine-containing toxins elucidate the trapping mechanism of channel block and provide a template for designing new drugs. @shantigangwar @MariaKarela3 @LauraYen42 @MKCMU
https://t.co/29ITjucSaW

[Science Colab @ScienceColab]

If you're interested in biophysics and want to contribute to positive change in scientific publishing, follow our first community venture @BiophysicsColab

#OAWeek24 #ScienceCommunity #FutureofPublishing

[Alexander Sobolevsky @AlexanderSobol6]

Happy to share the conformational ensemble of wild-type human TRPV3. For the first time the channel structure is open by applying agonists, 2-APB or THCV, without sensitizing mutations! @knadezhdinPhD @arthurCantab @IrinaTalyzina https://t.co/rWltNPZUbZ

[Chakrapani_Lab @Chakrapani_lab]

Structural Basis for Partial Agonism in 5-HT3ARs. Tremendous effort from @KevinCFelt Maddy Stauffer, Leslie Salas-Estrada and a great collaboration with @martafilizola Pete Guzzo and Dejian Xie
https://t.co/XXncVnBkuw

[Journal of General Physiology @JGenPhysiol]

Permeant cations modulate pore dynamics and gating of TRPV1 #IonChannels. A new study from Miriam Garcia-Ávila, Javier Tello-Marmolejo, Tamara Rosenbaum @LutiEmir and León D. Islas @LeonDIslas @UNAM_MX: https://t.co/miPWUB8CU1

#CellularPhysiology #Biophysics

[Pita Segura @PittaSegura]

@VKalienkova @CPaulino_ @MartinPeter91 @rheinbergerj I just read the paper and it is awesome 👏🏻 congratulations !!!

[Pita Segura @PittaSegura]

@giraldezT @SBEsp @FMorenoHerrero Muchas felicidades!!! 🎉Siempre siendo una gran inspiración para muchos 🤗

[Teresa Giraldez @giraldezT]

SEMINAR ALERT ‼️

THIS COMING MONDAY July 3rd

RECI Webinar - 17h CET

*Prof. Dr. Andrew Plested*
Humboldt-Universität Zu Berlin
@AndrewPlested

“Glutamate Receptors: from structure to synapse”

EVERYONE INVITED: https://t.co/GzlUJ6JnlR

-Please RT-🙏🏻

[eLife Community @eLifeCommunity]

Mexico’s central government has been tightening its grip on scientific research, cutting funding and intimidating academics.

In the latest #SparksOfChange, a researcher speaks up about his fears for the future. https://t.co/irKNtIRL1T

[Scott Earley @vesselman]

Faulty TRPM4 channels underlie age-dependent cerebral vascular dysfunction in Gould syndrome | Proceedings of the National Academy of Sciences https://t.co/UA7dFEyLjb
Check out out latest paper, part of an amazing collaboration with @UCSFGouldLab !

[Pita Segura @PittaSegura]

@CPaulino_ Congratulations, I wish you much success in this new adventure. 🎉🍾

[Pita Segura @PittaSegura]

@Cladoni @lfsantana68 @mf_navedo @hERGologie @MichaelRegnier9 @eabuffalo @casa_tuthill @yasesancak Congratulations! I send you a big hug !! It is very inspiring and motivating see how you reach your goals.

[Pita Segura @PittaSegura]

I like to see how all your effort and passion are reflected in such an exceptional work, congratulations @jjdejp

[Journal of General Physiology @JGenPhysiol]

De Jesús-Pérez, Arreola et al. @LaUASLP show that a reciprocal regulation between key gating elements and permeant anions sets the calcium and voltage sensitivities and the anion selectivity of the calcium-activated chloride channel TMEM16A. https://t.co/nQdTmu45IX

#IonChannels

[Wenlei @peter_leaf]

Charge-screening mechanism at the pore/gate interface. This is exactly how TMEM16 works~ @jjdejp and collaborators have provided amazingly persuasive evidence! Congratulations!