Domenico Pontillo

Biostatistician
Department of Anesthesia and Intensive Care of @SanRaffaeleMI

[Domenico Pontillo @PontilloD_]

🚨 Our fantastic #RCT just published in @NEJM! 🚨

🩸 Can Acute Normovolemic Hemodilution (ANH) reduce RBC #transfusion in cardiac surgery? 🫀

❓ What were the results?
Click to find out 👉 https://t.co/ec3rIbO9yk

#CardiacSurgery #NEJM #PerioperativeCare

[NEJM @NEJM]

Original Article: Daraxonrasib or Chemotherapy in Previously Treated Metastatic Pancreatic Cancer (phase 3 RASolute 302 trial) https://t.co/y4G27hfORg

#ASCO26 | @ASCO

[Rosario Losiggio, MD @LosiggioRosario]

Today I had the honor of participating as a speaker at the 37th SMART Congress.

It was a great opportunity to discuss the new frontiers of acute kidney injury, including early diagnosis, precision medicine, and the potential role of emerging biomarkers.

Ad maiora! 💙

[Giovanni Landoni, MD @giovannilandoni]

in milan, @LosiggioRosario is presenting on renal buomarkers @Smart_Meeting_M

[Giovanni Landoni, MD @giovannilandoni]

Dear Ozgun @OzgunOasiller ,
You had a beautiful mind, and you were only 30 years old.

Last year, you spent weeks in our hospital as an ESAIC mentee from Ankara. In that short time, you left a mark on all of us. We miss you deeply.

[Domenico Pontillo @PontilloD_]

🚨 New publication alert using TriNetX real-world data

👥 >100,000 young adults with septic shock
⚖️ Propensity-matched cohort

♀️ Women aged 18–55 had lower 28-day mortality than men: RR 0.92 (95% CI 0.89–0.95)

⏳ After age 55, this difference disappeared

🔗https://t.co/4slAOSi6lw

@JCriticalCare
@giovannilandoni @alebelletti1 @SFresilli @RosaLabanca5 @mariottichia_
#TriNetX #RealWorldData #SepticShock #CriticalCare

[San Raffaele Anesthesia and Intensive Care @SRAnesthesiaICU]

The #PROGRESStrial protocol is out: an ongoing multicenter RCT testing whether a prehabilitation program can reduce major postoperative complications and facilitate recovery in patients undergoing major oncological gastrointestinal surgery. 🏋️‍♂️

🔗 https://t.co/aPosz3MU4h

[Giovanni Landoni, MD @giovannilandoni]

This article on #AMINOACIDS for prevention of #AKI is more important than our @NEJM

Hundreds of centers which are implementing perioperative AA based on the #PROTECTIONtrial and European guidelines should limit the duraton of infusion of AA to<=48 h https://t.co/q7DLwUnxzX

[Rosario Losiggio, MD @LosiggioRosario]

Today at #ITACTAIC2026 in Bologna, great insights on the “hub & spoke” model for cardiogenic shock, current evidence and future perspectives to build faster, more integrated, multidisciplinary networks

👏 @MarinaPieri5

[San Raffaele Anesthesia and Intensive Care @SRAnesthesiaICU]

In this secondary analysis of the #PROTECTIONtrial, the renal protective effect of amino acid infusion after cardiac surgery was similar in diabetic and non-diabetic patients, supporting its use for all patients undergoing cardiac surgery.

🔗 https://t.co/FcVufXlEyF

[Matteo Borello @BorelloMatteo]

Domani verrà pubblicato su YouTube e Spotify il primo episodio di PodcAnest, un podcast sviluppato dal CPAR a cui ho collaborato

Lo scopo di spiegare il mondo dell’Anestesia e Rianimazione ai non medici e agli studenti di medicina

Il primo episodio parlerà di Donazioni d’organo

[San Raffaele Anesthesia and Intensive Care @SRAnesthesiaICU]

In our meta-analysis including 34 trials and >5000 patients, ANH did not reduce the proportion of cardiac surgery patients who received allogeneic pRBC transfusions during the postoperative hospital stay 🩸

📎 @BJAJournals https://t.co/Pd7oiKMIfU

[San Raffaele Anesthesia and Intensive Care @SRAnesthesiaICU]

🎉 Congratulations to the Xijing Hospital: top 2026 enrolling center in the #LUNAtrial! Thank you to the ACRC & the Cardiac Anesthesia Team for their outstanding work. Special recognition to Prof. Chong Lei, PI, for exceptional leadership in high-quality clinical research!

[Rosario Losiggio, MD @LosiggioRosario]

🫀Just published in @BJAJournals
Our meta-analysis of 17 RCTs (n=3,813) shows no reduction in allogeneic pRBC transfusion with #AcuteNormovolaemicHaemodilution vs standard care (40% vs 43%; RR 0.94, 95%CI 0.85-1.02; I² 80%)

Don't miss the full-text https://t.co/R4WZ5ScyD0
#ANH

[M Velia Antonini @FOAMecmo]

Bayesian statistics for clinical research:
❓what is the Bayesian statistical framework and how does it work?
⚖️ Bayesian vs frequentist statistics: fundamental conceptual differences
🔍 specifying prior distributions
🔮 interpreting posterior distributions
🖋️ drawing conclusions from Bayesian analyses
❓what difference does Bayesian thinking make? interpretation & design of clinical trials, Bayesian hierarchical models
Owing to its fundamentally different conception of probability, Bayesian statistics offers an intuitive, flexible, and informative approach that facilitates the design, analysis, and interpretation of trials.
🔗 https://t.co/263ywUAvhJ

[Rosario Losiggio, MD @LosiggioRosario]

In diabetic pts from the #PROTECTIONtrial, #AminoAcids infusion showed a 97.5% posterior probability of #AKI reduction
The AA beneficial effects don't change in high risk pts!

Dozens of centers worldwide are already implementing AA in routine clinical practice!
What about you?⬇️

[Signa Vitae @MRE_signavitae]

💊Antifibrotic drugs like Pirfenidone & Nintedanib decrease mortality by 40% in Acute Lung Injury patients (such as COVID-19)!

🏥This Meta-analysis suggests that this therapy could greatly benefit ALI patients: NNT=13!

⁉️Could this change post-ICU care? What do you think?

Read more:
https://t.co/Yo9iTYeiSS

#AntifibroticTherapy #AcuteLungInjury #PulmonaryFibrosis #COVID19 #CriticalCare #MedicalResearch #ICU #MetaAnalysis #Perfenidone
#MedEd #MedTwitter

[Rosa Labanca @RosaLabanca5]

Drug of the Year 🏆 Clevidipine demonstrated superior efficacy compared with nitroglycerin for blood pressure control during carotid endarterectomy. Proud of this publication and excited to use such an outstanding medication in clinical practice. 💉✨
https://t.co/LI1ePtEHs7

[ISICEM @ISICEM]

𝐒𝐞𝐫𝐢𝐨𝐮𝐬 𝐬𝐜𝐢𝐞𝐧𝐜𝐞. 𝐔𝐧𝐞𝐱𝐩𝐞𝐜𝐭𝐞𝐝 𝐟𝐨𝐫𝐦𝐚𝐭.
The @ISICEM Critical Care Input — presented this time in a new way. Watch it now and enjoy.
Credits @DrFDamico
#ISICEMelearning @NEJM
Full article https://t.co/rOeUBP3bQE

[Filippo D'Amico @DrFDamico]

🏥 San Raffaele lancia il corso per professionisti dedicato alla pre-abilitazione preoperatoria 📣

🏃‍♂️ Attività fisica e valutazione funzionale
🥗 Ottimizzazione nutrizionale
🧠 Preparazione psicologica e gestione dello stress

👉 per migliori outcome postoperatori

🎓 Per fisioterapisti, nutrizionisti, psicologi e medici.

https://t.co/e9lfjwJZ8P

[Sara Bacilieri @BacilieriSara]

💰 Intravenous amino acids work—and they save money

A new multi-country economic evaluation shows AA infusions are both cost-saving and cost-effective in preventing AKI after cardiac surgery.

🔗 Help us map all AA solutions available: https://t.co/7VAZiSEvfS