๐จ Our fantastic #RCT just published in @NEJM! ๐จ
๐ฉธ Can Acute Normovolemic Hemodilution (ANH) reduce RBC #transfusion in cardiac surgery? ๐ซ
โ What were the results?
Click to find out ๐ https://t.co/ec3rIbO9yk
#CardiacSurgery#NEJM#PerioperativeCare
Original Article: Daraxonrasib or Chemotherapy in Previously Treated Metastatic Pancreatic Cancer (phase 3 RASolute 302 trial) https://t.co/y4G27hfORg
#ASCO26 | @ASCO
Today I had the honor of participating as a speaker at the 37th SMART Congress.
It was a great opportunity to discuss the new frontiers of acute kidney injury, including early diagnosis, precision medicine, and the potential role of emerging biomarkers.
Ad maiora! ๐
Dear Ozgun @OzgunOasiller ,
You had a beautiful mind, and you were only 30 years old.
Last year, you spent weeks in our hospital as an ESAIC mentee from Ankara. In that short time, you left a mark on all of us. We miss you deeply.
๐จ New publication alert using TriNetX real-world data
๐ฅ >100,000 young adults with septic shock
โ๏ธ Propensity-matched cohort
โ๏ธ Women aged 18โ55 had lower 28-day mortality than men: RR 0.92 (95% CI 0.89โ0.95)
โณ After age 55, this difference disappeared
๐https://t.co/4slAOSi6lw
@JCriticalCare@giovannilandoni@alebelletti1@SFresilli@RosaLabanca5@mariottichia_
#TriNetX #RealWorldData #SepticShock #CriticalCare
The #PROGRESStrial protocol is out: an ongoing multicenter RCT testing whether a prehabilitation program can reduce major postoperative complications and facilitate recovery in patients undergoing major oncological gastrointestinal surgery. ๐๏ธโโ๏ธ
๐ https://t.co/aPosz3MU4h
This article on #AMINOACIDS for prevention of #AKI is more important than our @NEJM
Hundreds of centers which are implementing perioperative AA based on the #PROTECTIONtrial and European guidelines should limit the duraton of infusion of AA to<=48 h https://t.co/q7DLwUnxzX
Today at #ITACTAIC2026 in Bologna, great insights on the โhub & spokeโ model for cardiogenic shock, current evidence and future perspectives to build faster, more integrated, multidisciplinary networks
๐ @MarinaPieri5
In this secondary analysis of the #PROTECTIONtrial, the renal protective effect of amino acid infusion after cardiac surgery was similar in diabetic and non-diabetic patients, supporting its use for all patients undergoing cardiac surgery.
๐ https://t.co/FcVufXlEyF
Domani verrร pubblicato su YouTube e Spotify il primo episodio di PodcAnest, un podcast sviluppato dal CPAR a cui ho collaborato
Lo scopo di spiegare il mondo dellโAnestesia e Rianimazione ai non medici e agli studenti di medicina
Il primo episodio parlerร di Donazioni dโorgano
In our meta-analysis including 34 trials and >5000 patients, ANH did not reduce the proportion of cardiac surgery patients who received allogeneic pRBC transfusions during the postoperative hospital stay ๐ฉธ
๐ @BJAJournals https://t.co/Pd7oiKMIfU
๐ Congratulations to the Xijing Hospital: top 2026 enrolling center in the #LUNAtrial! Thank you to the ACRC & the Cardiac Anesthesia Team for their outstanding work. Special recognition to Prof. Chong Lei, PI, for exceptional leadership in high-quality clinical research!
๐ซJust published in @BJAJournals
Our meta-analysis of 17 RCTs (n=3,813) shows no reduction in allogeneic pRBC transfusion with #AcuteNormovolaemicHaemodilution vs standard care (40% vs 43%; RR 0.94, 95%CI 0.85-1.02; Iยฒ 80%)
Don't miss the full-text https://t.co/R4WZ5ScyD0
#ANH
Bayesian statistics for clinical research:
โwhat is the Bayesian statistical framework and how does it work?
โ๏ธ Bayesian vs frequentist statistics: fundamental conceptual differences
๐ specifying prior distributions
๐ฎ interpreting posterior distributions
๐๏ธ drawing conclusions from Bayesian analyses
โwhat difference does Bayesian thinking make? interpretation & design of clinical trials, Bayesian hierarchical models
Owing to its fundamentally different conception of probability, Bayesian statistics offers an intuitive, flexible, and informative approach that facilitates the design, analysis, and interpretation of trials.
๐ https://t.co/263ywUAvhJ
In diabetic pts from the #PROTECTIONtrial, #AminoAcids infusion showed a 97.5% posterior probability of #AKI reduction
The AA beneficial effects don't change in high risk pts!
Dozens of centers worldwide are already implementing AA in routine clinical practice!
What about you?โฌ๏ธ
๐Antifibrotic drugs like Pirfenidone & Nintedanib decrease mortality by 40% in Acute Lung Injury patients (such as COVID-19)!
๐ฅThis Meta-analysis suggests that this therapy could greatly benefit ALI patients: NNT=13!
โ๏ธCould this change post-ICU care? What do you think?
Read more:
https://t.co/Yo9iTYeiSS
#AntifibroticTherapy #AcuteLungInjury #PulmonaryFibrosis #COVID19 #CriticalCare #MedicalResearch #ICU #MetaAnalysis #Perfenidone
#MedEd #MedTwitter
Drug of the Year ๐ Clevidipine demonstrated superior efficacy compared with nitroglycerin for blood pressure control during carotid endarterectomy. Proud of this publication and excited to use such an outstanding medication in clinical practice. ๐โจ
https://t.co/LI1ePtEHs7
๐๐๐ซ๐ข๐จ๐ฎ๐ฌ ๐ฌ๐๐ข๐๐ง๐๐. ๐๐ง๐๐ฑ๐ฉ๐๐๐ญ๐๐ ๐๐จ๐ซ๐ฆ๐๐ญ.
The @ISICEM Critical Care Input โ presented this time in a new way. Watch it now and enjoy.
Credits @DrFDamico#ISICEMelearning@NEJM
Full article https://t.co/rOeUBP3bQE
๐ฅ San Raffaele lancia il corso per professionisti dedicato alla pre-abilitazione preoperatoria ๐ฃ
๐โโ๏ธ Attivitร fisica e valutazione funzionale
๐ฅ Ottimizzazione nutrizionale
๐ง Preparazione psicologica e gestione dello stress
๐ per migliori outcome postoperatori
๐ Per fisioterapisti, nutrizionisti, psicologi e medici.
https://t.co/e9lfjwJZ8P
๐ฐ Intravenous amino acids workโand they save money
A new multi-country economic evaluation shows AA infusions are both cost-saving and cost-effective in preventing AKI after cardiac surgery.
๐ Help us map all AA solutions available: https://t.co/7VAZiSEvfS