Praneet

It's POSSIBLE!

[Praneet @PraneetSahoo]

The concept of 'finite' often corrupts a man's mind.

[Carnivore Aurelius ©🥩 ☀️🦙 @AlpacaAurelius]

You need to be delusionally optimistic.

Didnt sleep well? Tell yourself you did and youll actually feel better.
Weak? Visualize strength and youll actually be stronger.
Lifting? Tell yourself youre on steroids.
Poor? Feel rich, live like you are, and youll become it.

The mind is the most powerful tool.

[Naval @naval]

The time to be most ambitious is when you have nothing to lose or nothing left to gain.

[Praneet @PraneetSahoo]

Congrats Elon Musk!

[Praneet @PraneetSahoo]

Before you marry your sweetheart, consider the prospective in-laws.

[Bryan Johnson @bryan_johnson]

This new perspective study reports that our brains are carrying 3,000x more microplastic than our blood.

Microplastic burden of the human brain rose ~50% between 2016 and 2024.

The average brain now carries roughly:

> 11x the load of the liver
> 11x the kidney, and on a per-mass basis around
> 3,000x the concentration found in circulating blood (on a per-mass basis)

This study argues that eliminating ultra-processed foods (i.e. chicken mcnuggets, breaded shrimp) carries an additional benefit: reducing brain microplastic accumulation.

This is based on an inferred chain of mechanisms rather than proven causality in humans, yet the convergence is striking.

The paper outlines four pathways through which microplastics plausibly damage the brain:

> oxidative stress and chronic inflammation
> endocrine disruption
> gut-microbiome injury
> and vascular damage.

These map onto various brain and mental diseases including: depression, anxiety, cognitive decline, stroke, dementia.

The same conditions are independently linked to ultra-processed food consumption in large prospective cohorts

Each 10% increase in ultra processed food intake
> 25% higher dementia risk
> 16% higher cognitive impairment risk
> 8% higher stroke risk

High versus low ultra processed food consumption tracks with 44% higher odds of depression and 48% higher odds of anxiety.

While we do not yet have a human study showing UPF intake directly raises brain microplastic burden. Here is what we do have:

A study found that the more processed forms of protein foods carry significantly more microplastic particles.

> Chicken nuggets contained 31x more microplastics per gram than raw chicken breast (least processed item in the study)

> Breaded shrimp, the most processed item in the study, carried ~130x the level in raw chicken breast (caveat: shrimp also carries higher baseline contamination from ocean and water pollution)

> A 1,031-woman pregnancy cohort showed each 10% higher UPF intake tracked with 13.1% higher urinary phthalates, the plasticizers that leach from food packaging

Microplastics cross from the blood to the brain.

Animal research shows mechanistically how microplastic particles do cross the blood-brain barrier.

In mice, polystyrene nanoparticles at 293 nm reached the brain within 2 hours of oral exposure. Particles at 1.14 μm and 9.55 μm did not cross at all.

While most microscopy-based microplastic tests have a detection floor around 1 μm.

The fraction that actually crosses into the brain sits below that threshold. If a test picks up larger particles in your blood, the smaller, BBB-crossing fraction is almost certainly there too, just below the detection window.

The big ones are a proxy for the dangerous small ones.

Cut all microplastic input where you can and avoid ultra processed foods, this another important one.

In addition: use a water filtration system for your drinking water, reverse osmosis with remineralization is the gold standard.

I recently reported complete elimination of microplastics from my semen (first in human demonstration) and a 87% reduction in my blood.

[Praneet @PraneetSahoo]

It takes years. Then happens all at once.

[Gigi 🇻🇪 @itsthatgigi]

My retirement plan but it’s missing:
- a husband
- 3 to 6 kids
- horses
- flower garden
- water near

What else would you add?

[Carnivore Aurelius ©🥩 ☀️🦙 @AlpacaAurelius]

great relationship advice

marriage is one long conversation

find someone you love talking to

[Praneet @PraneetSahoo]

Stop being patient and start asking yourself, how do I accomplish my 10 year plan in 6 months? You'll probably fail, but you'll be a lot further ahead of the person who simply accepted it was going to take 10 years.

-E.M.

[Praneet @PraneetSahoo]

We're clearly missing something about how biological intelligence works. If we understood the brain's algorithm better, we might find radically more efficient approaches.

[Praneet @PraneetSahoo]

Human brain: ~20 watts / ~86B neurons / ~100T+ synapses
GPT-4 training: ~50+ GWh total (~MW-scale clusters for months) / ~1.8T parameters
GPT-4 inference: ~0.3 Wh per query today; servers ~several kW each
Yet the brain does vastly more general cognition with 10,000×+ LESS energy.

[Joe Rogan Podcast News @joeroganhq]

Alex Hormozi: “I promise you, every single person who wants to do something with their life and has done something with their life has gone through the exact chapter you’re going through.”

[Matt Shumer @mattshumer_]

https://t.co/ivXRKXJvQg

[Carnivore Aurelius ©🥩 ☀️🦙 @AlpacaAurelius]

life works in reverse

fail a lot --> you'll succeed
stop trying to impress others --> end up doing something very impressive
stop chasing a relationship --> find your soul mate
do less --> accomplish way more
let go of making money --> make lots of money
discipline yourself --> find freedom
stop trying to fit in --> you'll find lots of friends
spend lots of time alone --> you'll never feel lonely

[Praneet @PraneetSahoo]

Why think worse and suffer from pain for things that haven't happened yet, while you can think good and feel the joy of what might be? After all, both are imaginary at their foundation.

[Praneet @PraneetSahoo]

@shiri_shh Hi !!

[Oliur @UltraLinx]

Can you read 900 words per minute? Try it.