Steve

Just Another Random

[Allie K. Miller @alliekmiller]

When brainstorming new AI agent uses, I always remind myself what used to be expensive and is now nearly zero…

1) cost of reading everything fell → you can now watch 100% instead of a sample (every expense, every call, every camera)

2) cost of making one more fell → abundance (12 custom onboarding decks instead of one, 100 social posts generated from one book)

3) cost of an expert opinion fell → a reviewer on every doc (every contract I sign goes through one in addition to my lawyer, medical results, scientific paper explanations)

4) cost of a conversation fell → one tutor/coach/SDR per person

5) cost of trying fell → ginkgo bioworks running 36000 experiments, Sherpa trying thousands of websites

6) cost of whole new roles fell → I hired a “dreamer” (Phoebe) who overlays my business and ideates and tests new ways of thinking/working , hired Toby who maintains memory and efficiency across my org - two roles I wouldn’t have hired a dedicated human for

[Steve @Project_MESH_]

@AlexFinn Dont you think they will stop us from using Chinese models, specially if they claim fable level intelligence

[Steve @Project_MESH_]

@MattyJAdams @middocapital Well said ...I had forgotten this crazy story!!!

[Ryo Lu @ryolu_]

from apps to material

software used to be something you opened

an app was a room with walls: calendar here, notes there, music there, work there. each one had its own logic, buttons, its own little kingdom. the user moved between kingdoms, carrying context in their head

but ai starts to break the walls

software becomes less like a destination and more like material. something you shape, combine, stretch, ask, remix, and leave behind as traces. a document can become an app. a conversation can become a workflow. a song can become a memory. a task can become an agent. the boundary between using and making gets blurry

the old model was: choose the right tool for each task

the new model is: express the shape of the thing you want, then refine it with the system you built

this changes the role of the interface. ui is no longer only fixed views for fixed functions. it becomes a surface where intent turns into structure. the best interfaces will feel less like menus and more like clay – responsive, persistent, inspectable, and alive

apps won’t disappear. rooms are still useful. but the deeper shift is that software stops being a set of sealed containers and becomes a medium people can think through

like paper, but executable
like language, but spatial
like memory, but programmable

software stops being something only programmers make

it becomes material anyone can shape

[Steve @Project_MESH_]

@Teknium @gdb I wonder if they are playing favorites between open claw and Hermes

[Steve @Project_MESH_]

@jessegenet so cool

[Michal Komar @michalkomar]

AYi: Karpathy's CLAUDE.md is 65 lines that took AI coding from 65% to 94% accuracy. No tricks, just 4 rules pointing one direction: think before you code, state assumptions, ask when uncertain, start simple. Worth reading before your next AI pair programming session.

[Wes Roth @WesRoth]

Google launched a free Google AI Studio feature that lets users build native Android apps directly inside AI Studio without coding.

The feature has already been used to create more than 250,000 Android apps since launching last week.

[Seth Howes @SethSHowes]

I just sequenced a human genome to 30× coverage entirely at home.

As far as I know, this is the first time this has been done.

I didn’t step foot in a lab once. Every step - from saliva collection, to running the sequencer - took place in a single room with a dining table + kitchenette.

Six weeks ago, I had never done wet lab biology before.

I used an Oxford Nanopore P2 Solo - the only commercially available sequencing device portable enough to do 30x human genome sequencing at home.

Biggest takeaway - I could build something that combined software, hardware, and molecular biology far faster than I thought was possible.

I can name >100 specific instances where AI helped me solve a technical problem that would previously have blocked me because I lacked access to a domain expert.

For example: how do I save my sequencing run when my DNA extraction yield is 4x lower than I need it to be, and I have this limited set of reagents to hand?

To make this work, I had to navigate multiple disciplines:

- writing software to monitor sequencing runs and orchestrate remote GPU infra for basecalling
- learning + executing 5 hour long molecular biology protocols
- building a hardware device to quantify DNA concentration

Apologies for the hyperbole, but I feel super lucky to be living in 2026.

A few weeks ago I decided to sequence a human genome to 30x at home.

Then I actually did it. And I did it really quickly.

[Brian Allen @allenanalysis]

Jeff Bezos just said the bottom half of Americans should pay zero federal income tax.

And honestly? He may have accidentally exposed the entire scam.

Bezos pointed to a nurse in Queens making roughly $75,000 a year and paying around $12,000 in taxes:

“We shouldn’t be asking this nurse in Queens to send money to Washington.”

Think about how insane this system has become.

A nurse working 12-hour shifts is taxed before she even sees her paycheck while billionaires borrow against appreciating assets, exploit loopholes, and sometimes pay lower effective tax rates than school teachers.

The average American is funding an empire they can barely afford to live in.

Wars.
Interest payments.
Corporate subsidies.
Defense contracts.
Lobbyist wish lists.

Meanwhile the person changing bedpans in Queens gets her paycheck carved up like she’s financing Rome before collapse.

The most dangerous thing Bezos said wasn’t about taxes.

It was admitting out loud that the people carrying the country on their backs are getting crushed while the system tells them it’s “normal.”

[Steve @Project_MESH_]

@Claudiashein por que alegar con periodistas todas las mañanas?
no ahi mejor uso de su tiempo
perdido de tiempo, no dice nada, y de seguro es estresante todos los mañana

[Teknium 🪽 @Teknium]

Help this fella out with his question everyone ^_^

[Gaurav @AI_303030]

https://t.co/0rA5jg9Tnp

[Steve @Project_MESH_]

@grok @JustinPerea @shanegriffiths @NousResearch What would fliping on the runtime do, if your already using codex oauth? What
Would be a diffrence

[Melvin Luu @luluneverstops]

social fluency is a learnable skill.

most people think you’re either charismatic / extroverted or you’re not.

wrong. you train it like a muscle.

the easiest rep: one compliment to a stranger a day for 14 days.

drop it and keep walking. no conversation required. zero pressure.

but sometimes they stop you. sometimes it turns into 5 minutes that give your whole day texture. sometimes it leads somewhere you didn’t expect.

by day 14 you’re on a diff frequency. i dont know how else to say it. people feel it before you open your mouth. they look at you when you enter a room.

then go to 3 a day for another 14 days.

after 30 days you’ll talk to anyone.

you entered social god mode.

turns out you were never introverted.

you just missed the reps to be comfortable in social situations.

suddenly you start craving the wholesome hit of a real human moment with a stranger.

and you realize:

most of lifes best moments are often just one sentence away.

[Melvin Luu @luluneverstops]

if you feel stuck, change your inputs immediately.

same room. same phone. same thoughts. same loop.

youre recycling the same signal.

new inputs in the next 4 hours:

-one conversation with a stranger
-one hour reading a book youd never read
-one walk in a neighborhood you’ve never been to
-one thing you’ve never done before

momentum is physical before it’s mental.

[Avid @Av1dlive]

Andrej Karpathy : 10x engineers are normal. real agentic engineers are 100x

this guy just shipped the playbook to become 100x

context engineering. tool design. orchestrator-subagent. evals. the harness mindset.

watch & bookmark it for this weekend

[Andrew Ng @AndrewYNg]

How we prompt AI is very different in 2026 than 2022 when ChatGPT came out.

I'm teaching a new course, AI Prompting for Everyone, to help you become an AI power user — whatever your current skill level.

It covers skills that apply across ChatGPT, Gemini, Claude, and other AI tools. How to use deep research mode for well-researched reports on complex questions. How to give AI the right context, including more documents and images than most people realize you can provide. When to ask AI to think hard for several minutes on important decisions like what car to buy, what to study, or what job to take. And how to use AI to generate images, analyze data, and build simple games and websites.

I also cover intuitions about how these models work under the hood, so you know when to trust an answer and when not to.

Along the way, you'll see flying squirrels, a creativity test, some of my old family photos, and fireworks.

Join me at https://t.co/tcQc4iJAJG

[Steve @Project_MESH_]

@paulg Permanent decline ...??? Damn. You dont think we can turn this around? I like to think the people of America and around the world are better than our goverments make us out to be. I refuse to believe the people of any country believe war is the answer

[Digi @digiii]

I don’t know who needs to hear this but you must f*ck around and figure it out. Chase an obsession. Network like a psychopath. Use AI to answer hard questions. Throw your phone in a draw. Avoid dopamine addiction. Work in a flow state for 8-10 hours. Your life is the result of the shots you take, not the dreams you have. Stop overthinking and just make the next 6 months count. Take more action than seems rational.