Tau and Tauopathies

Here to share advances in tau research! Please tag and follow if interested in tau and tauopathies.

[Walczak Lab @WalczakLab]

Today we report in @J_A_C_S the first chemical synthesis of microtubule-associated protein tau.
Congratulations to @wyattpowel87711 and @Jing_Ruiheng on this monumental accomplishment. 🎉👏 #TauSynthesis
1/n

https://t.co/we76VHchi6

[Tau and Tauopathies @ProteinTau49976]

Central and peripheral tau retention modulated by an anti-tau antibody

https://t.co/UU2aKSmHFZ

[Tau and Tauopathies @ProteinTau49976]

Spatial transcriptomic patterns underlying regional vulnerability to amyloid-β and tau pathologies and their relationships to cognitive dysfunction in Alzheimer's disease

https://t.co/OYCTk1YjHR

[Tau and Tauopathies @ProteinTau49976]

Phosphorylation of a Cleaved Tau Proteoform at a Single Residue Inhibits Binding to the E3 Ubiquitin Ligase, CHIP

https://t.co/wick7DdfKk

[Tau and Tauopathies @ProteinTau49976]

Emerging diagnostics and therapeutics for Alzheimer disease

https://t.co/MKituA4Xkm

[Tau and Tauopathies @ProteinTau49976]

Exendin-4 ameliorates tau hyperphosphorylation and cognitive impairment in type 2 diabetes through acting on Wnt/β-catenin/NeuroD1 pathway

https://t.co/2Z50biwBNr

[Tau and Tauopathies @ProteinTau49976]

ApoE4 expression disrupts tau uptake, trafficking, and clearance in astrocytes

https://t.co/2lF2EXZDna

[Tau and Tauopathies @ProteinTau49976]

Methylene blue accelerates liquid-to-gel transition of tau condensates impacting tau function and pathology

https://t.co/J1nFFc5dzB

[Tau and Tauopathies @ProteinTau49976]

Reinstated Activity of Human Tau-induced Enhanced Insulin Signaling Restricts Disease Pathogenesis by Regulating the Functioning of Kinases/Phosphatases and Tau Hyperphosphorylation in Drosophila

https://t.co/UUSdmBC92m

[Tau and Tauopathies @ProteinTau49976]

Amyloid and tau-PET in early-onset AD: Baseline data from the Longitudinal Early-onset Alzheimer's Disease Study (LEADS)

https://t.co/7jAfkM8BmZ

[Tau and Tauopathies @ProteinTau49976]

A Small Tau Fragment Specifically Templates Four Repeat Tau Aggregates Through Multiple Generations

https://t.co/eFQoF2S4WE

[Tau and Tauopathies @ProteinTau49976]

Tau fibrils induce nanoscale membrane damage and nucleate cytosolic tau at lysosomes

https://t.co/tbijbjyB4R

[Tau and Tauopathies @ProteinTau49976]

Age-Dependent Increase in Tau Phosphorylation at Serine 396 in Huntington's Disease Prefrontal Cortex

https://t.co/iw2wApuzRG

[Tau and Tauopathies @ProteinTau49976]

Why kiss-and-hop explains that tau does not stabilize microtubules and does not interfere with axonal transport (at physiological conditions)

https://t.co/LbbgWrY1ca

[Tau and Tauopathies @ProteinTau49976]

Structure challenges in the multivalency of Tau-microtubule interactions

https://t.co/WYEwdWHQRG

[Tau and Tauopathies @ProteinTau49976]

Glial reactivity and T cell infiltration in frontotemporal lobar degeneration with tau pathology

https://t.co/MQjUF6KfqO

[Tau and Tauopathies @ProteinTau49976]

Phosphorylation of MAP 1A regulates Hyperphosphorylation of Tau in Alzheimer's Disease Model

https://t.co/ZRHRbj9wy8

[Tau and Tauopathies @ProteinTau49976]

α-synuclein drives tau´s cytotoxic aggregates formation through hydrophobic interactions

https://t.co/2pTbqaSSMM

[ShorterLab @ShorterLab]

TMEM106B Fibrils from FTLD Patients and Healthy Controls: https://t.co/SRFwlA8Vsg

[ShorterLab @ShorterLab]

It was great to organize and guest edit the latest issue of @ACSChemRev on Phase Separation with Sua Myong @MyongLab2: https://t.co/HZTLj8J6eM