Walczak Lab

Official Account of the Walczak Lab at CU-Boulder. Chemical tools to drive new discoveries in the life sciences.

[Walczak Lab @WalczakLab]

We're thrilled to share our new @J_A_C_S publication revealing how N-glycosylation shapes tau protein behavior. Check it out at https://t.co/LtrWGivIxb

[Walczak Lab @WalczakLab]

A warm welcome to the first-year graduate students joining the Walczak lab - Himanshu, Zachary, Tania, Cat, Lily and Antawn!

[Walczak Lab @WalczakLab]

We’re excited to share that our latest paper is officially published in its final form at @ACSCentSci! Huge thanks to everyone involved in making this work possible.

https://t.co/78m0Z0xwbN

[Walczak Lab @WalczakLab]

@Sumit_glycan @J_A_C_S @i_am_santosh Thank you, Sumit!

[Walczak Lab @WalczakLab]

A new paper in @J_A_C_S describing the synthesis of Si-linked glycomimetics. Congratulations to @i_am_santosh, Timmy, Nick and Kyle! https://t.co/GgONM2J1WJ

[Walczak Lab @WalczakLab]

@samuccen @J_A_C_S @i_am_santosh Thank you, Sam!

[Walczak Lab @WalczakLab]

Congratulations Kyle Fisch for receiving the NSF GRFP! Excited for the discoveries and impact you'll make in grad school and beyond. @CUBoulder @CUBoulderCHEM

[Walczak Lab @WalczakLab]

@BrimbleM @Boron_Chemistry @DrH_aucklanduni @JOC_OL Thank you for the swift and efficient editorial process at Organic Letters! It was a pleasure contributing to the journal.

[Walczak Lab @WalczakLab]

Our group's latest research on tetrahydroxydiboron-mediated reactions in peptide/protein chemistry is now published in @JOC_OL. A huge congrats to @Jing_Ruiheng!
https://t.co/izTcSpDLzn

[Walczak Lab @WalczakLab]

A new pre-print from our lab available on @biorxivpreprint

Post-Translational Modifications Control Phase Transitions of Tau https://t.co/rXfDYBzzVP

[Walczak Lab @WalczakLab]

Happy New Year from everyone at the Walczak Lab! Wishing you all a year of prosperity, both professionally and personally. 🥳🎉🥳

[Walczak Lab @WalczakLab]

Only two weeks left to apply to our graduate program at @CUBoulderCHEM!

https://t.co/edGpU6tHXw

[Walczak Lab @WalczakLab]

Join our virtual Open House on October 26th to explore our vibrant graduate program. Please help spread the word by sharing this invitation.🌟@CUBoulderCHEM @CUBoulder

https://t.co/3NZCI7EoEt

[Walczak Lab @WalczakLab]

@huang_shaofeng @J_A_C_S @Jing_Ruiheng @wyattpowel87711 Thanks, Shaofeng!

[Walczak Lab @WalczakLab]

We're excited to reveal our latest study on desulfurative borylation in @J_A_C_S ! Congrats to @Jing_Ruiheng, @wyattpowel87711, and Kyle!

https://t.co/N4pyfQuHii

[Walczak Lab @WalczakLab]

@ShahmoraLab @J_A_C_S @Jing_Ruiheng @wyattpowel87711 Thanks Sarah!

[Walczak Lab @WalczakLab]

@weizhangCU @J_A_C_S @Jing_Ruiheng @wyattpowel87711 Thanks, Wei!

[Walczak Lab @WalczakLab]

@AhmadMasarwa2 @JbaraM90 @J_A_C_S @Jing_Ruiheng @wyattpowel87711 Thank you, Mhmad!

[Walczak Lab @WalczakLab]

Stay tuned as we unveil more results and delve into intricate mechanistic studies.

[Walczak Lab @WalczakLab]

Today we report in @J_A_C_S the first chemical synthesis of microtubule-associated protein tau.
Congratulations to @wyattpowel87711 and @Jing_Ruiheng on this monumental accomplishment. 🎉👏 #TauSynthesis
1/n

https://t.co/we76VHchi6

[Walczak Lab @WalczakLab]

Tau undergoes extensive post-translational modifications, but what truly stands out is the contrasting expression of these modifications in healthy and Alzheimer's afflicted brains. 🧠💡

[Walczak Lab @WalczakLab]

Our approach to investigate PTMs in tau revolves around chemical synthesis. We successfully combined 11 distinct fragments through a sequence of highly efficient ligations to produce the longest 2N4R isoform.