Pruneda Lab

collectively ran by the Pruneda lab, MMI, Oregon Health & Science University @ohsummi | our views are our own

[Paola Antonello @Paola632898361]

Great talk by Rachel Lacoursiere from @PrunedaLab regarding bacterial enzymes to understand non canonical ubiquitination #EMBOubiquitin24

[Jonathan Pruneda @jnpruneda]

Excited to share this work from former @PrunedaLab superstar @camgroberts! Cam tackled the challenge of identifying #ubiquitin regulators secreted by pathogenic bacteria, and found an entirely new type of E3 ligase that regulates P. aeruginosa virulence!
https://t.co/KgL0yYUek3

[Rune Busk Damgaard @rbdamgaard]

Fantastic to have @jnpruneda @PrunedaLab from @OHSUSOM visiting giving a seminar on his team’s exciting work on how pathogenic bacteria use nifty effector proteins to hijack the ubiquitin system and avoid the host response. Real pleasure to have you at @DTUbioengineer, Jonathan.

[Pruneda Lab @PrunedaLab]

As #RareDiseaseDay rapidly approaches, please consider contributing to our collaboration with @RaidenScience to study a rare pediatric disorder.

[Raiden Science Foundation @RaidenScience]

Our Annual Run4Raiden 5K is back! ⚡️🦓

This year's fundraising goal is to raise $60K to continue our UBA5 drug repurposing program. 🧬🔬

Sign Up or Donate Today: https://t.co/pYSY6SzkNv

@OHSUNews @jnpruneda @RuthJeanNapier

[Jonathan Pruneda @jnpruneda]

Please consider supporting @RaidenScience! We’re determined to find a way to help children afflicted with this rare #ubiquitin-related disease.

[Jonathan Pruneda @jnpruneda]

Pleased to share the final version of this work on UBA5, available at @eLife.

https://t.co/7x9hVGgNto

[Jonathan Pruneda @jnpruneda]

Excited to share the final product of this work, now available at @MolecularCell. Extremely proud of @tylergfranklin for this and many other achievements during his thesis work!

https://t.co/rpp6LOfeK3

[Pruneda Lab @PrunedaLab]

Great job @tylergfranklin!

[Jonathan Pruneda @jnpruneda]

Yesterday the @PrunedaLab produced its first PhD scientist! Congratulations @tylergfranklin on five years of incredible growth and science, capped by a fantastic thesis defense. Added bonus: his paper was accepted on the same day! Keep an eye on this one, he’ll do great things.

[Achim Werner @werner_achim]

New preprint identifying shared and distinct mechanisms of inactivation of the #ubiquitin E1 enzyme #UBA1 across different diseases #VEXAS #SMA #lungcancer https://t.co/nPqiBmF5C7
Thanks to David Beck @nyulangone, @kyliejwalters and all contributors for a great collaboration!

[Jonathan Pruneda @jnpruneda]

Excited to share our new review on bacterial effectors that follow or break the "rules" of #ubiquitin signaling. Always a pleasure to work with @camgroberts and @tylergfranklin!
https://t.co/bLgLZm1rw8

[Jonathan Pruneda @jnpruneda]

Bacteria can counter noncanonical lipid ubiquitination with a #ubiquitin esterase! Fantastic collaboration with @ThurstonLab and @CMBI_Szczesna, with @r_lacoursiere driving our side of the project using some amazing tools built by the Geurink lab.

[Teresa Thurston @ThurstonLab]

Excited to share our preprint on how a cytosolic bacteria evades LPS ubiquitylation and antibacterial autophagy through an effector with esterase activity. Led by @CMBI_Szczesna in the lab @ImperialInfect @CBRB_Imperial with superb collaborator @jnpruneda https://t.co/jvXqxWBMFu

[Jonathan Pruneda @jnpruneda]

What can bacteria teach us about #ubiquitin? A lot!
In our latest preprint, @tylergfranklin set out to understand how secreted bacterial ligases catalyze ubiquitin modifications during infection. What he found will surprise you!
https://t.co/IlOCPeg1uH

[Jonathan Pruneda @jnpruneda]

Happy to share that this work is now online in its peer-reviewed form at @MolecularCell. Huge thanks to our peer reviewers for challenging us, and to my co-authors for rising to meet this challenge. Check out the final product! https://t.co/IiiPi1VERJ

[Pruneda Lab @PrunedaLab]

Great job Tyler!

[Kylie Walters (she/her) @kyliejwalters]

Grad student 1st time presenter ⁦⁦@tylergfranklin⁩ impressed us all ⁦@FASEBorg⁩ Ub with cool Ub chain engineering; shown here with his PhD advisor ⁦@jnpruneda⁩

[Jonathan Pruneda @jnpruneda]

I’m very excited to share our latest work, in which we identify, characterize, and apply a Legionella deubiquitinase that targets host Lys6-linked #ubiquitin signals with extreme precision. https://t.co/Tpf1kLUgv6

[Ruth Jean Napier @ruthjeannapier.bsky.social @RuthJeanNapier]

Proud to 🚀 the #RaidenScienceFoundation including Nobel Laureate Dr. Ciechanovar, @UMassChan @PrunedaLab @StJude and @BCMFromtheLabs
..who will together develop a treatment for #UBA5, an ultra-rare neurodegenerative disease.
https://t.co/72V5aJt05j

[Pruneda Lab @PrunedaLab]

Congratulations @camgroberts!

[Jonathan Pruneda @jnpruneda]

Ever tried to give a 3-minute research presentation? It isn't easy! @PrunedaLab member @camgroberts gave a fantastic flash talk at #UKcellmicro2021 this week and even won a prize! Congratulations to Cam and thank you to the organizers for such a great meeting!

[Jonathan Pruneda @jnpruneda]

Ever tried to give a 3-minute research presentation? It isn't easy! @PrunedaLab member @camgroberts gave a fantastic flash talk at #UKcellmicro2021 this week and even won a prize! Congratulations to Cam and thank you to the organizers for such a great meeting!

[Pruneda Lab @PrunedaLab]

Of course Justine did a fantastic job, we were never DUBious! So proud of @justinevnguyen!

[Jonathan Pruneda @jnpruneda]

Huge congratulations to @PrunedaLab member @justinevnguyen for skillfully defending her Master’s thesis on bacterial deubiquitinases today! Well done Justine!