A random internet stranger

[A random internet stranger @RNAViralContent]

@michaelzlin @bardleyford Ok, I see there is different data from the immunogenicity/efficacy study (spikevax vs mnexspike), and it shows milder side effects for mnexspike https://t.co/RN75DiDkLb

[A random internet stranger @RNAViralContent]

@michaelzlin @bardleyford This has been my anecdotal experience, but the approval study documents seem to show HIGHER systemic side effects for mnexspike (comparator vaccine is the bivalent Moderna, 50ug). I’m confused!

[A random internet stranger @RNAViralContent]

@JenniferNuzzo After Ed Sheeran the first name that came to mind is honestly The Weeknd. Probably not appropriate for an 11 year old but all his songs are whining about feelings

[A random internet stranger @RNAViralContent]

@michaelmina_lab @jvipondmd @jamesdailyUSA @loulou_root @AprilinBC @C19TestFinders I figured this out because I had someone else get a false positive lucira, otherwise very rare, and they ALSO did a throat swab. I’ve overseen tons of Luciras that were nose-only and never seen a false positive. Sounds like throat swabs with LAMP tests cause false positives!

[A random internet stranger @RNAViralContent]

@michaelmina_lab @jvipondmd @jamesdailyUSA @loulou_root @AprilinBC @C19TestFinders Belated update: Hey @michaelmina_lab, while recovering from covid this week, I think I solved the mystery of my positive Lucira earlier this year! For the test in question, I did a throat swab in addition to nose. I bet you anything this was the problem: https://t.co/RaTMrWMonW

[A random internet stranger @RNAViralContent]

@Biff248824 @EmiDoesMath Oh cool! Thank you!!

[A random internet stranger @RNAViralContent]

@ColinJCarlson Might be inclined to try something like this

[A random internet stranger @RNAViralContent]

@florian_krammer The seasonal coronaviruses are already a relatively diverse bunch, right? Why do you think adding SARS-CoV-2 to the mix increases breadth so much?

Is it an age effect? Are antibodies to seasonal CoVs more narrowly targeted since they’re developed and refined earlier in life?

[A random internet stranger @RNAViralContent]

@michaelmina_lab @EugeneShats @awyllie13 Lucira no longer on market, hasn’t been for months, except for resellers with soon-expiring stock.

[A random internet stranger @RNAViralContent]

@michaelmina_lab @jvipondmd @jamesdailyUSA @loulou_root @AprilinBC @C19TestFinders I’m skeptical of that, because I had similar circumstances in January—faint positive Binax+FlowFlex, which led to 5 NAAT (Lucira & Cue) tests. One (Lucira) was positive, four negative.

If I had stopped at the first NAAT (neg Lucira), it would have been the same situation as now.

[A random internet stranger @RNAViralContent]

@michaelmina_lab @jvipondmd @jamesdailyUSA @loulou_root @AprilinBC @C19TestFinders A few months after my exposure I got a negative test for N antibodies, though I know asymptomatic infections often don’t seroconvert.

I’m not worried about my health; I’m treating these as negatives. Just idly curious what’s happening under the hood of these tests (and my nose).

[A random internet stranger @RNAViralContent]

@michaelmina_lab @jvipondmd @jamesdailyUSA @loulou_root @AprilinBC @C19TestFinders I didn’t know this was a possibility!

I’m once again (we talked about this in January) getting weird faint lines on both Binax and FlowFlex after a lot of indoor socializing. Negative Lucira after a careful swab. I was coughing for a night but that might have been the wildfires.

[A random internet stranger @RNAViralContent]

@EmiDoesMath @alexaleehassan Thanks, yeah, I saw that last night when I was digging into it! Will be happy if something actually comes of it!

[A random internet stranger @RNAViralContent]

@EmiDoesMath @alexaleehassan Any chance you can figure out where you heard this? I think people on other forums might be referring to your tweet now as a source.

A rep from Peach Medical on reddit says they don’t think Pfizer will restart production and speculates that they bought Lucira for patents.

[A random internet stranger @RNAViralContent]

@michaelmina_lab @greg_howard @alexmeshkin The first study excluded single isolated PCR positives (they don’t say how many). The second doesn’t clarify. But even excluding single positives, where are the “minimally positive for two days in a row and then negative” asymptomatics, if that’s a common thing? cc: @genepedia

[A random internet stranger @RNAViralContent]

@michaelmina_lab @greg_howard @alexmeshkin Seems easy to say “that’s just an infection that was quickly cleared by your immune system,” but what bugs me about that is, if you look at the NBA data, or studies like (1) https://t.co/a9iV5JlmK1 or (2) https://t.co/fQ1jBVwcug you don’t see a lot of “interrupted infections.”

[A random internet stranger @RNAViralContent]

@JudyMinkoff @notdred (But the population of people with the flu probably also have higher-than-average risk of covid exposure, so maybe they have an outsized impact. Anyway, thanks for the study/answers!)

[A random internet stranger @RNAViralContent]

@JudyMinkoff @notdred Gotcha! I was reading it with Ed’s narrow question in mind, and thinking, even if you posit that IAV confers 100% immunity for a week, the impact on covid couldn’t be TOO big, since only 1-2% of the population is in that brief post-flu period at any given time during a flu wave.