@michaelzlin@bardleyford Ok, I see there is different data from the immunogenicity/efficacy study (spikevax vs mnexspike), and it shows milder side effects for mnexspike https://t.co/RN75DiDkLb
@michaelzlin@bardleyford This has been my anecdotal experience, but the approval study documents seem to show HIGHER systemic side effects for mnexspike (comparator vaccine is the bivalent Moderna, 50ug). I’m confused!
@JenniferNuzzo After Ed Sheeran the first name that came to mind is honestly The Weeknd. Probably not appropriate for an 11 year old but all his songs are whining about feelings
@michaelmina_lab@jvipondmd@jamesdailyUSA@loulou_root@AprilinBC@C19TestFinders I figured this out because I had someone else get a false positive lucira, otherwise very rare, and they ALSO did a throat swab. I’ve overseen tons of Luciras that were nose-only and never seen a false positive. Sounds like throat swabs with LAMP tests cause false positives!
@florian_krammer The seasonal coronaviruses are already a relatively diverse bunch, right? Why do you think adding SARS-CoV-2 to the mix increases breadth so much?
Is it an age effect? Are antibodies to seasonal CoVs more narrowly targeted since they’re developed and refined earlier in life?
@michaelmina_lab@jvipondmd@jamesdailyUSA@loulou_root@AprilinBC@C19TestFinders I’m skeptical of that, because I had similar circumstances in January—faint positive Binax+FlowFlex, which led to 5 NAAT (Lucira & Cue) tests. One (Lucira) was positive, four negative.
If I had stopped at the first NAAT (neg Lucira), it would have been the same situation as now.
@michaelmina_lab@jvipondmd@jamesdailyUSA@loulou_root@AprilinBC@C19TestFinders A few months after my exposure I got a negative test for N antibodies, though I know asymptomatic infections often don’t seroconvert.
I’m not worried about my health; I’m treating these as negatives. Just idly curious what’s happening under the hood of these tests (and my nose).
@michaelmina_lab@jvipondmd@jamesdailyUSA@loulou_root@AprilinBC@C19TestFinders I didn’t know this was a possibility!
I’m once again (we talked about this in January) getting weird faint lines on both Binax and FlowFlex after a lot of indoor socializing. Negative Lucira after a careful swab. I was coughing for a night but that might have been the wildfires.
@EmiDoesMath @alexaleehassan Any chance you can figure out where you heard this? I think people on other forums might be referring to your tweet now as a source.
A rep from Peach Medical on reddit says they don’t think Pfizer will restart production and speculates that they bought Lucira for patents.
@michaelmina_lab@greg_howard@alexmeshkin The first study excluded single isolated PCR positives (they don’t say how many). The second doesn’t clarify. But even excluding single positives, where are the “minimally positive for two days in a row and then negative” asymptomatics, if that’s a common thing? cc: @genepedia
@michaelmina_lab@greg_howard@alexmeshkin Seems easy to say “that’s just an infection that was quickly cleared by your immune system,” but what bugs me about that is, if you look at the NBA data, or studies like (1) https://t.co/a9iV5JlmK1 or (2) https://t.co/fQ1jBVwcug you don’t see a lot of “interrupted infections.”
@JudyMinkoff@notdred (But the population of people with the flu probably also have higher-than-average risk of covid exposure, so maybe they have an outsized impact. Anyway, thanks for the study/answers!)
@JudyMinkoff@notdred Gotcha! I was reading it with Ed’s narrow question in mind, and thinking, even if you posit that IAV confers 100% immunity for a week, the impact on covid couldn’t be TOO big, since only 1-2% of the population is in that brief post-flu period at any given time during a flu wave.