Interesting findings by @SantagataLab showing the presence of HSF1 condensates in tumors and their dissolution promotes activation of HSF1 transcriptional targets. Findings suggest condensate properties can be used manipulate cell fate
https://t.co/CDRVK7Hc9O
An interesting approach to target the finite ways by which cancer cells develop drug resistance.
Pharmacologically controlling protein-protein interactions through epichaperomes for therapeutic vulnerability in… https://t.co/GxQ2Vv4Rex
Congratulations to Blair's group for their finding that overexpression of FKBP52 or AHA1 is in itself sufficient to induce hallmarks of AD in mice. The findings point to an interesting mechanism of chaperone imbalance in the initiation of AD.
doi: 10.1186/s40478-021-01159-w