今日も阮愛妻です

shareholder of $LMND $Tsla & Precision Neuroscience @PrecisionNeuro_ ｜长桥LMND股主｜東京大学phd @UTokyo_News_en ｜奶爸

[今日も阮愛妻です @RYizhe]

Proud to be a shareholder of Precision Neuroscience @PrecisionNeuro_.
BCI is entering an exponential phase — from research frontier to real-world platform.
Excited to back the future of neural interfaces

[今日も阮愛妻です @RYizhe]

@JasonZX

[今日も阮愛妻です @RYizhe]

@turingou 终于能评论了

[Juan Benet @juanbenet]

Here is Episode 2 of my new podcast dedicated to conversations on the future of neurotech, computing, intelligence, and more.

My guest Dr. Ben Rapoport is co-founder and CSO of Precision Neuroscience (@PrecisionNeuro_), Assistant Professor of Neurosurgery at the Icahn School of Medicine at Mount Sinai, and Scientific Director at Mount Sinai. Previously, he co-founded Neuralink and Simbionics (acquired by Apple).

Precision is building a minimally invasive brain-computer interface (BCI) that reads from thousands of points on the cortex without penetrating it. The Layer 7 device is implanted through a one-millimeter slit in the skull rather than the larger borehole other approaches require. It is also fully removable.

Precision seeks to help the 5 million people living with severe paralysis in the US (including 800,000 new stroke cases per year). In March 2025, Precision received FDA clearance for a temporary wired version of the system. Over 85 patients have been implanted with and used the device in clinical studies (50 at the time of our conversation). Wireless implants are planned for 2027.

We go deep on the history of Neurotech from the 1980s to the ML inflection points that triggered Neuralink's founding, why surface ECoG was a contrarian bet that's now paying off, the path to treating paralysis and stroke at scale, and why Ben believes neural data is at the same inflection point genomic data was in 2000 — a whole class of biological problems about to become tractable as computer science problems.

Chapters
00:00:00 Introduction
00:04:39 Paralysis as a lens to understand the brain
00:05:36 The 1980s breakthrough: population encoding and the birth of BCI
00:14:36 Google Translate, ML, and the founding of Neuralink
00:23:08 What is the long-term vision of Precision Neuroscience
00:31:56 Layer 7 and why transformative technology looks impossible at first
00:50:21 The surgery: a slit in the skull, not a borehole
00:55:19 The clinical program: who are the patients
01:04:16 FDA clearance and the path to wireless implants in 2027
01:08:32 The patient population: paralysis and stroke at scale
01:16:26 Neural data as the new genomics
01:30:06 BCIs, AI, and the future of the human-machine interface
01:31:22 From medical necessity to lifestyle technology
01:40:36 Precision as a platform — and an optimistic vision

If you're interested in these kinds of discussions, subscribe to the podcast. And if there’s anyone you’d like to see or hear on the podcast, reply with your suggestions.

Full Episode 2 here and in other platforms below.

[今日も阮愛妻です @RYizhe]

确实是硬件层，二月份和openai合作了项目，简单来说云实验室现在允许coding agent在物理层面执行生物实验的标准操作了，深度用过codex/claude code之后我感觉这部分想象力蛮大的，有点像coding agent在生物实验里执行层。公司目前的战略在转型自动化实验的云算力。虽然收入营收现在很差，但我主要关注这个trend

[今日も阮愛妻です @RYizhe]

@lidangzzz 看figure在二级市场挂的卖单就知道了，好公司谁会卖优先股？

[今日も阮愛妻です @RYizhe]

小X：今天去春游，学了中国话

[今日も阮愛妻です @RYizhe]

马斯克这到哪都拍照发推的习惯，爱泼斯坦肯定不跟他玩😃

[今日も阮愛妻です @RYizhe]

@XianyuLi 脑机赛道被指数级加速的时代来了

[今日も阮愛妻です @RYizhe]

@XianyuLi 这是家公司 @PrecisionNeuro_

[今日も阮愛妻です @RYizhe]

@zwlego @_FORAB 是的，而且很难靠背调来确定

[今日も阮愛妻です @RYizhe]

@xwang_sh @myanTokenGeek 学习的目的是在于强化自身。经常会幻想一个场景，当自己穿越回古代，你能否用自己的知识，把现代科技搬运过来。

[今日も阮愛妻です @RYizhe]

@Rustallintsla codex挺好用啊，claude code用一下就没了，性价比极低

[今日も阮愛妻です @RYizhe]

@zwlego @_FORAB 上市之后公司层面是限制不了，但说到底如果是远期合约的话，买家并不拥有股权，股权还在卖家名下，即使是签了远期合约的合同，如果卖家毁约也是很麻烦的。毕竟你钱已经给卖家了，卖家并没有把股份给你

[今日も阮愛妻です @RYizhe]

@hazenlee 这个好这个好

[今日も阮愛妻です @RYizhe]

重新给评论区科普��下，正式的pre-ipo交易，标准流程是走ROFR，公司，卖家，买家三方共同签署一份Stock Transfer Agreement。具有强法律效益。对于每一笔正规场外交易，每一笔都需要公司ceo，买家（个人或者SPV），卖家双方签字。小散买的这些热门股票，就买的这点量，还真配不上马斯克，山姆奥特曼的签字跟你们在同一个文件。

[今日も阮愛妻です @RYizhe]

@JasonZX 原来如此，那确实是跨时代的升级了