SARS-CoV-2 can infect human neurons. Here is our study on the virus entry pathway and inhibition of infection in neurons. Big thanks to the fantastic team.
https://t.co/2RH7Pu9OV4
The combined use of apilimod with camostat mesylate or nafamostat mesylatethat synergistically inhibits the two host factors that facilitate SARS-CoV2 entry into the cells and, prevents the SARS-CoV2 infection in different cell types. #COVID19#SARSCoV2
https://t.co/laRZugPqp1
2 compounds, 7-hydroxystaurosporine & bafetinib, have synergistic antiviral effects and inhibit viral-induced syncytia formation in vitro.
Our study on #drugdiscovery
Computationally prioritized drugs inhibit SARS-CoV-2 infection and syncytia formation https://t.co/4RxMT5PLqV
Open Sesame! Researchers discovered the second ‘key’ used by the SARS-CoV-2 virus to enter into human cells | University of Helsinki https://t.co/0f8BgLmlk6
Now out in Science: Furin cleavage of SARS-CoV2 Spike creates a "C-end rule" site for enhanced cell entry via neuropilin-1. A new therapeutic target revealed. A big effort at UH BSL-3s and a great collaboration led by Mikael Simons and Giuseppe Balistreri https://t.co/BfiKnkfgVl
Helping explain what makes #SARSCOV2 so capable of infecting human cells, researchers in two independent studies discovered that the virus’s spike protein recognizes and binds a protein on the human cell surface called neuropilin-1 https://t.co/kA73KHnvCw; https://t.co/Mwn1XBltyk
So proud to be part of this amazing project.
"Neuropilin-1 facilitates SARS-CoV-2 cell entry and provides a possible pathway into the central nervous system"
bioRxiv viewer https://t.co/uUpSg1WK8u