We're learning more about the N-terminal domain (NTD) of #SARSCoV2 and how its epitopes can promote immune evasion. The latest is one that binds the heme metabolites biliverdin and bilirubin with high affinity
https://t.co/OOvjmnPKjU @ScienceAdvances
@emilytjoness hi dear Emily, are You o.k. after pfizer vaccine already, all back to normal without residual vaccine aftereffects ? thx for info, pharmacovigilance
Very rare cases of pericarditis, myocarditis are being seen after mRNA vaccines. We've seen a few here in San Diego, too. It's time to get a handle on frequency and determine the mechanism.
See @AllaqabanSuhail and @ihsan_rafie posts, threads
ECGs via Dr. Allaqaband
Men who took fish oil supplements for 3 months had higher semen volume, total sperm count, testis size, and higher free testosterone to LH ratio compared with no supplement intake. The results were dose-dependent with greater supplementation frequency.
https://t.co/b2UcM0QIlJ
The best part of this new #SARSCoV2 multiomics study @nature today (transcriptome, proteome, ubiquitinome, phosphoproteome and interactome) is the simplicity of its findings :-) https://t.co/R3ZrAlJNln
Multiple reports with this overall ranking of neutralization, relative immune evasion
Here are a few:
https://t.co/RMHe35zx4I
https://t.co/nfxT17RFGa
https://t.co/1S0TeStkgK
A brilliant review of covid immunothrombosis: how the infection can lead to hyper-inflammation and blood vessel wall dysfunction --> clotting, and how it can be treated https://t.co/xiSbU9zihQ @NatRevImmunol by @aldobonaventura@kmartinod@AbbateAntonio and colleagues @VCU
Covid can induce cell fusion with multiucleated cells in the lung and heart. So these investigators searched through 3000 approved drugs that block that and found one—niclosamide—that that works against tapeworm with much promise vs #SARSCoV2
https://t.co/mkdHAfE7BD @nature
How do you find 37 new repurposed drugs that have direct #3D binding to #SARSCoV2's main protease to knock out its ability to replicate?
Like they did, with X-ray crystallography screening. Just published @ScienceMagazine
https://t.co/aT7zEiYjZS
Why NACI's recommendation to suspend the AZ vaccine in people aged < 55 makes sense.
1. We don't know the risk of clotting. Initial estimates from Germany were 4 per million. Subsequent Norwegian estimates are 10 x that (42 per million).
2. As noted previously...
For the past two weeks, my colleague @GretchenVogel1 and I have been trying to understand what researchers know so far about the rare cases of serious blood clotting observed in people that got the AstraZeneca #covid19 vaccine.
Our story is up here:
https://t.co/4UvKnohyTH
‘ONE NEAT TRICK’ for #COVID19 vaccine:
Yes, sounds clickbait-y, but there actually was a special technique developed to enhance the vaccine to be more effective—by adding a “double proline” (2-P) to stabilize the spike.
Took years to discover it! Neat.
https://t.co/REB0ry2PgJ