Carolina Reduzzi

PhD, working on translational #CancerResearch and #LiquidBiopsies @WeillCornell
Young Committee Chair @isliquidbiopsy

[Carolina Reduzzi @ReduzziCarol]

Today we launched the "ISLB Global Survey: Oncologist Attitudes and Practices on Liquid Biopsy" to collect worldwide data on the use of liquid biopsy in clinical practice!
Help us sharing the survey with all the oncologists you know :)
https://t.co/UfwHSj5Pn3

[WCM Englander Institute for Precision Medicine @WCMEnglanderIPM]

Congrats to Scientific Director Dr. Massimo Cristofanilli (@MassimoCristof09) & Dr. Carolina Reduzzi (@ReduzziCarol) on their new @ScienceTMpaper, "Dual-positive #CTCs in patients with advanced #breastcancer show metastatic potential and prognostic value."
https://t.co/NZ33UQ6gnb

[Science Translational Medicine @ScienceTM]

Researchers present one of the largest analyses of dual-positive #CTCs in patients, tracing how these cells correlate with outcomes in advanced #BreastCancer and how they seed metastasis in mice. @CtcLaboratory @ReduzziCarol @WeillCornell https://t.co/us1Df13FyB

[Enes Erul MD @ErulEnes]

A drop of blood, a wealth of insight.

What did #SABCS2025 teach us about liquid biopsy in breast cancer?

Gratefull to @DrYukselUrun my grand mentor !

A privilege to be part of this amazing unique @isliquidbiopsy

@UmbertoMalapel1 @RobertoBoreaMD @ChristianRolfo @ElJanLe

[Roberto Borea, MD @RobertoBoreaMD]

⌛️ Such a timely and important paper from the @isliquidbiopsy
🩸#LiquidBiopsy is evolving dramatically fast, and terminology must be updated with the advancements!

@UmbertoMalapel1 @ChristianRolfo @drgandara @MJOSESERRANO19 @LuisRaezMD @ReduzziCarol @DrYukselUrun @nicolafusco

[Sergio Cifuentes @Onco_Cifu88]

🚨 SABCS25 Highlight | PHERGuide (PHERGain translational ctDNA analysis)
A major step forward in reshaping early HER2+ breast cancer management.

Key findings from this ctDNA-guided translational study:
🔬 Baseline insights:

• ctDNA detected in 71% of patients; associated with stage & nodal status.
• Baseline ctDNA did NOT predict pCR — reinforcing that tumor biology is dynamic, not static.
⚡ Early treatment dynamics:

• ctDNA clearance by C3D1 strongly correlated with pCR (p=0.003).
• Early molecular response outperformed baseline biomarkers.
🧬 Pre-surgery signal (most impactful):

• 83% achieved ctDNA clearance pre-surgery.
• 0% of patients with detectable ctDNA at surgery achieved pCR — a powerful negative predictive marker.
• Pre-surgery ctDNA positivity associated with worse 3-year iDFS.
📈 Survival:

• Both baseline ctDNA negativity and ctDNA clearance (early & late) predicted significantly better 3-year iDFS.
🌍 Why this matters now:

This study strengthens a growing paradigm:
ctDNA is emerging as an actionable tool to refine risk stratification, guide treatment escalation/de-escalation, and potentially reshape how we personalize therapy in early HER2+ disease—beyond imaging and pathology.
🔜 Clinical horizon:

• Identify high-risk patients who may benefit from novel escalation (e.g., T-DXd strategies).
• Support de-escalation trials for early molecular responders.
• Integrate methylation-based ctDNA assays into upcoming HER2+ adjuvant/neo-adjuvant designs.
An important translational contribution from PHERGain, pointing to the future of molecularly adaptive treatment in HER2+ eBC.

@OncoAlert @weoncologists @ReduzziCarol

[PMAC group @PMAC_group]

🚀 Our launch event was a success!
It featured an insightful discussion & a deeply moving patient testimonial that underscored the urgency of our mission.

🙌 Thank you for fueling our work!

Our momentum continues straight to SABCS!
Here our abstracts: https://t.co/WpV49zc38n

[Dana-Farber’s Breast Oncology Center @DFCI_BreastOnc]

New Study 👉Circulating tumor cells dynamics after CDK4/6 inhibitor for hormone-receptor positive #MetastaticBreastCancer: A biomarker analysis from the PACE phase II study. #ctDNA #MNC #BreastCancer
📎https://t.co/gPQaVax5Pk
@LGerratana @ReduzziCarol @RMJesel @AngieDemichele @jane_meisel @YAbdouMD @KUMedCenter @NaomiKoMD @DrHBurstein @MKDeMeo @stolaney1 @elmayermd

[International Society of Liquid Biopsy @isliquidbiopsy]

Great paper from our ISLB Young Committee!
A huge effort to keep sharing #LiquidBiopsy knowledge through reviews and editorials after major conferences worldwide.

Follow us for more LB updates and insights! 🌍🧬
#ISLB #sciencecommunication

[Lorenzo Gerratana @LGerratana]

DESTINYBreast06 at #ASCO25 suggests a greater benefit from T-DXd in BRCA1/2-mutant #MBC (HR 0.17)

‼️Small N (20 pts)

🧬 biologically plausible synergy via DNA damage.

⚠️ Still no data on key biomarkers like ERBB2

#BreastCancer #ADC #Biomarkers #PrecisionMedicine

[Carolina Reduzzi @ReduzziCarol]

If you are a young researcher with an interest in liquid biopsy, come talk to us at the @isliquidbiopsy booth at #ASCO2025 about the activities of the Young Committee and how to join! @robertobore

[David Gandara @drgandara]

#ISLB at our booth with members of ISLB " Young Committee", led by amazing Carolina Reduzzi. Only at ISLB is there an organized & empowered committee of young investigators, conducting its own research, educational events, & publishes its own work. Come join us @isliquidbiopsy

[International Society of Liquid Biopsy @isliquidbiopsy]

Here with @drgandara , ISLB CMO, and some amazing members of the ISLB Young Committee! 🙌

Great to meet in person and share ideas 💡on how to keep growing together.

Excited for what’s ahead! the best is yet to come!

#ASCO25 @Booth12041
@ReduzziCarol @mgoudaMD @RobertoBoreaMD @eleonoranicolo @letipontolillo @shurbisinghal

[Roberto Borea, MD @RobertoBoreaMD]

Super excited to share our latest review in the Journal of Liquid Biopsy on the huge impact of LB in oncology! 🩸🔬

LB is reshaping cancer care💥

👉https://t.co/q0CUtv1n8P

@isliquidbiopsy @ReduzziCarol @OSUCCC_James @rolfolab @WeillCornell @UmbertoMalapel1 @ChristianRolfo

[WCM Englander Institute for Precision Medicine @WCMEnglanderIPM]

🩸👀See how @WCMEnglanderIPM is using #LiquidBiopsy to improve #PrecisionMedicine w/
@HashemAGH @GuardantHealth

https://t.co/59BkE13bl4

[OncoDaily @oncodaily]

The Liquid Biopsy Platform is launching a new seminar series within the HemOnc Seminar Talk - Carolina Reduzzi (@ReduzziCarol)
@WeillCornell

https://t.co/QsBXsu99Rw

#OncoDaily #Oncology #Cancer #Health #Medicine #MedTwitter #MedEd #MedOnc #MedNews

[Christian Rolfo @ChristianRolfo]

2025 ISLB Annual Congress, will take place in Orlando, Florida, November 1-3, 2025. This is an extraordinary gathering of scientists, clinicians, industry leaders, and innovators, all united by a shared passion for advancing liquid biopsy https://t.co/djipdLKYJX

[OncoDaily @oncodaily]

The International Society of Liquid Biopsy (@isliquidbiopsy) is conducting a global survey on the use of Liquid Biopsy in clinical practice. Your input will help shape strategies to improve its implementation and effectiveness in cancer care worldwide. 🌍
@ReduzziCarol

🔍https://t.co/CKtdZZzk57

#LiquidBiopsy #OncoDaily #HealthCare #Oncology #Cancer #Health #Medicine #CancerCare #MedTwitter #MedEd #MedOnc #MedNews

[Roberto Borea, MD @RobertoBoreaMD]

Now you can find the link to complete our @isliquidbiopsy survey in the @OncoAlert newsletter! 📨
It only takes 5 min to help us understand how LB 🩸 is reshaping clinical practice worldwide!

https://t.co/eUgyfeQJwz

@ReduzziCarol @ChristianRolfo @UmbertoMalapel1 @weoncologists

[gilberto lopes @GlopesMd]

https://t.co/sjY17xnyCa
Our meta-analysis aggregates data from more the 30 studies comprising 3000+ patients, showing that ctDNA decrease and clearance are strongly associated with PFS and OS in lung cancer. Results hold true for targeted treatments and immunotherapy! @iaslc #LCSM @GuardantHealth @LucenceHealth @ASCO @uicc Time is ripe to include as outcome in prospective studies so we can incorporate in decision making and drug approval process - @FDAOncology @JCOGO_ASCO @ASCOPost @JackWestMD @n8pennell @ChristianRolfo @StephenVLiu @myESMO @SylvesterCancer @cancermd @NarjustFlorezMD @Jani_Chinmay @Latinamd

[Huiping Liu @LiuCluster]

Our new #CTC review is published today via Elsevier. Congrats to the authors @youbin_zhang David Scholten, Wenan Qiang @LeonidasPlatan1 @DrWGradishar @ShanaOKelley @LurieCancer @NUFeinbergMed and @czbiohub Thanks to @ReduzziCarol and @LGerratana https://t.co/rbLK060xRv

[OncoAlert @OncoAlert]

Survey Participation Request on Behalf of
@isliquidbiopsy & @OncoAlert

Oncologist Attitudes and Practices on Liquid Biopsy
👉 https://t.co/mEPJX3T3A4

This survey aims to evaluate oncologists' attitudes, practices, and barriers to the use of liquid biopsy in clinical care. Your participation in this survey is voluntary. 10-15 minutes in length.

@ChristianRolfo
@UmbertoMalapel1
@drgandara
@DrYukselUrun
@CtcLaboratory
@mayoccc
@HeekeSimon
@ElJanLe
@MJOSESERRANO19
@LuisRaezMD
@aadel_chaudhuri
@ReduzziCarol
@rolfolab
@WeOncologists
@RobertoBoreaMD
@eleonora_nicolo
@AngeloDipa_
@ESaldanhaMD
@A_OrtegaFranco
@GeorgieDibs
@ddemiguelperez
@mgoudaMD
@RoisinDaly_
@KonVenetis
@PasqualePisapia