Reece Akana

Stanford PhD Candidate in the Cancer Biology Program

[Reece Akana @reece_akana]

@Vino_et_Vidya @PicturesFoIder Yuma?

[Andy Russell @AndyRusss]

Single-cell or spatial?

Our new technology - Slide-tags - allows both in the same experiment, enabling true single-cell multi-modal spatial genomics

➡️ https://t.co/i1m5T4bEme

[Sophien Kamoun @KamounLab]

Just released! This Amazing! #AlphaGenome — an AI system that predicts an organism’s genome sequence from its photograph.

It regularly achieves accuracy competitive with experiment. Beta version at 25% but now >99% for Homo sapiens!

[Niko McCarty. @NikoMcCarty]

An automated FACS machine 🧪

Takes a commercial instrument, and adds a robotic arm + software to auto-generate gates & send updates to Slack.

"Reduces hands-on effort by 93%"

A group at @czibiohub built the tools & open-sourced everything!

https://t.co/9zkHM1vyGd

[Niko McCarty. @NikoMcCarty]

There have been an incredible number of gene-editing advances (including in delivery) over the last three days.

Here are 7 of them...🧵

[Omar Abudayyeh @omarabudayyeh]

Today we report on a programmable technology for large-scale gene integration into the genome in @NatureBiotech which tries to solve a long-standing challenge in the gene editing field https://t.co/EdWoIAq7UP w @jgooten @MIT 1/x

[Oded Rechavi @OdedRechavi]

Almost every abstract has a line that says "however, bla bla bla is still poorly understood" and it's never clear what's the cutoff for being understood

[William L Hwang @DrWilliamHwang]

Our study on single-nucleus and spatial profiling of pancreatic cancer was published today @NatureGenet and will be the cover story in the August issue: https://t.co/stMOT1NZYc.

[Seth Shipman @seth_shipman]

I’m excited to introduce our Retro-Cascorder, out today in @Nature! This molecular device logs barcoded receipts of gene expression in a temporal genomic ledger. Sequence the ledger --> recover the history of gene expression. https://t.co/aGkyUbRBJW

[Joseph Replogle @josephmreplogle]

Our genome-scale Perturb-seq paper is out today in Cell! https://t.co/ErZZWSJ3VB @CellCellPress @JswLab

Thanks to all the authors and reviewers for their contributions. See the thread below for key findings.

[@IAmSciComm - On a Break! @iamscicomm]

A thread about using color as a design tool in science presentations. Color is a great tool to separate different categories of information, to highlight information, or to establish an emotional tone. 🧵1/20

[Livnat Jerby @LivnatJerby]

Excited to share that our @NatureBiotech paper with Aviv Regev on Multicellular Programs (MCPs) is now out with a fully automated data-driven method to identify MCPs from #singlecell or spatial data #behindthepaper: https://t.co/k7kPmW4NF0 https://t.co/bgcmYxPwnB (1/19)

[Laura Attardi @AttardiLaura]

Thrilled to share our latest work: #p53 suppresses cancer via the #Mettl3 #epitranscriptomic writer! Thanks to our great team and their lab members! @rajnitin @HowardYChang @PeterKJackson @cncurtis @seoanejav @mbarnalab
https://t.co/dYQE0uo3Gu

[Alex Ritter, PhD @AlexRitterPhD]

Small but mighty! This is a video of a killer T cell of the immune system destroying a monstrous ovarian cancer cell. I recently captured this data on a spinning disc confocal microscope.

[Julien Sage @SageJulien]

Excited to share the work from Noah “MC” Lee in the lab. Noah found a way to use Lenti-Cre and implement the Tuba-seq platform developed by @LabWinslow with the @PetrovADmitri lab in a mouse model of #SCLC, identifying TSC1 as a tumor suppressor in vivo https://t.co/Fh35NoxHCP

[Gerald Schwank @schwanklab]

Our in vivo prime editing study where we corrected a metabolic liver disease is finally out in STM. Congrats to Desiree, Tanja, Lukas and all other co-authors and many thanks to our collaborators! https://t.co/Y4gzWHEfqC

[Neville Sanjana @nevillesanjana]

New work from our lab: How can we program T-cells to make better immunotherapies? ⌨️💻🦠

Take a tour of the paper in this fantastic thread from first author (and multi-disciplinary innovator) @MatLegut ⤵️⤵️⤵️

[Aadel Chaudhuri, MD PhD @aadel_chaudhuri]

I teamed up with @AaronNewmanLab to answer an important clinical question via #liquidbiopsy:

Can peripheral blood features predict severe #immunotherapy toxicity?

Very excited to share our results @NatureMedicine: https://t.co/mpyIYLXmKl

[Ansu Satpathy @Satpathology]

To me, a major problem is the viewpoint that there is/should be a one-way flow from academia -> industry. Academia should recruit industry scientists at all levels and vice versa. Half of our lab has sig industry experience and it has transformed the way we approach questions.

[Craig Crews @CraigMCrews]

Ever wanted to quickly make a #PROTAC degrader of a #TranscriptionFactor? Check out our latest generation of TRAFTACs- just a TF binding sequence dsDNA oligo coupled to our VHL ligand. PoC studies degraded Myc and #brachyury. https://t.co/X1TbzwP3qu