Reem Abouward

Postdoc @ Sasi Conte’s lab at KCL, interested in RNA biology 🧪

[Reem Abouward @ReemAbouward]

It’s been an amazing journey studying how these organelles move and who they interact with in neurons. Very grateful to everyone who contributed to this work! @SchiavoMNPlab @ule_lab

[Reem Abouward @ReemAbouward]

Super excited that my PhD paper is now officially published - and even more thrilled that my neurons made the cover image of the issue!

https://t.co/kW269JNYp9

[J Cell Science @J_Cell_Sci]

Issue 3 is complete

Explore our ToC: https://t.co/iogtcQpQfc

On the cover: hiPSC-derived neurons labelled with the neuronal marker TUJ1 (blue), LAMP1 (green) & LAMP2 (red). The image highlights the heterogeneity of the neuronal endolysosomal system.
https://t.co/rQr1OJzYRY

[Reem Abouward @ReemAbouward]

In this paper, we investigated the transport dynamics of LAMP-positive organelles in human neurons and used blue light-activated proximity labeling to define the proximal interactomes of LAMP1 and LAMP2A.

[Anna Małkowska @MalkowskaAnna]

And for this year's Christmas, I get my PhD paper! @andreabrandlab https://t.co/QqJEoFIxlT

[Anna Małkowska @MalkowskaAnna]

Happy to share a preprint of my PhD work @andreabrandlab! We created a chromatin state model for quiescent and proliferating neural stem cells in Drosophila and found that quiescent cells gain active chromatin to support stem cell functions. https://t.co/pSSDShvdBx

[Reem Abouward @ReemAbouward]

@rupert_faraway Indeed hahaha

[Reem Abouward @ReemAbouward]

And that’s a wrap of what’s been a rollercoaster of a PhD.
I truly enjoyed my viva discussions and learnt so much!
Immensely grateful for my amazing lab members for seeing me through to the end of this journey and excited to do more RNA work in the Ule lab for the next year!

[Reem Abouward @ReemAbouward]

@MalkowskaAnna Can’t wait for yours !

[Reem Abouward @ReemAbouward]

@WaelSKamel Thank you!

[Reem Abouward @ReemAbouward]

😭😭😭 At least we are gonna be together in the same building 💁🏼‍♀️🧕🏽

[Emily Blackburn @EmilyBlackburn9]

Sad to be clearing out my bench in the @SchiavoMNPlab lab after 3 years but super excited to be starting my new job in the de Strooper & Arancibia lab at @TheCrick on Monday 😁😁😁

[Reem Abouward @ReemAbouward]

Amazing work by an amazing scientist ✨

[Rupert Faraway @rupert_faraway]

We identified a mechanism by which the homeostasis of class of proteins with similar low complexity domains (LCDs) is collectively regulated – ‘interstasis’. Interstasis operates at the level of the RNA that encodes those LCDs by exploiting the structure of the genetic code.

[Oliver Ziff @ojziff]

Our latest research published in @NeuroCellPress unveils widespread mislocalisation of RNA-binding proteins & mRNA in ALS motor neurons, shedding new light on the complexity of the disease. #ALS #MND

https://t.co/LO9ODY9m5W

[Reem Abouward @ReemAbouward]

I had a great time playing with everyone and chatting with the parents ❤️ it was a truly great experience and I cannot wait for next year to come already !!

[Emily Blackburn @EmilyBlackburn9]

Today marks the beginning of Down Syndrome Awareness week. As a priority, we need to empower people with Down syndrome and support them to make their own decisions.

[Emily Blackburn @EmilyBlackburn9]

Super excited for our World Down Syndrome Day event this Saturday! How great are our badges made by @BrotherEmporium for the @DSAInfo !! There’s still time to sign up if you haven’t already just email me [email protected] or click this link https://t.co/Dj67PapYTt

[Reem Abouward @ReemAbouward]

Super excited to see this out! Congratulations to this incredibly generous and wonderful team (esp @SongyiLee10 who’s given me early access to all the plasmids and was super patient with all my questions). LOV-Turbo is an amazing tool that has helped me so much in my PhD so far !

[Alice Ting @aliceyting]

Light-regulated TurboID, or LOV-Turbo, is a feat of engineered allostery, created by @SongyiLee10 and @CheahJoleen via structure-guided design, then optimized by yeast display directed evolution. Activity is nearly undetectable in the dark state, but increases within seconds to a level comparable to TurboID after weak blue-light illumination. Removing light shuts LOV-Turbo off again (ie, it is reversible).

LOV-Turbo is easy to use in mammalian cells, yeast, bacteria, and even in the mouse brain to suppress background labeling from endogenous biotin, to perform pulse-chase proteomics, and to spatially control biotinylation.

We also show that instead of external blue light, LOV-Turbo can be activated by genetically-encoded light, ie bioluminescence from luciferase, via BRET (Figure 4F-I).

Huge thanks to incredibly talented co-first authors @SongyiLee10 and @CheahJoleen, and our wonderful collaborators Steve Carr and @namude. Also many thanks to co-authors @Simenzhao, Charles Wu, @heegwangroh, @tinakim_neuro and @kelvinfcho for their contributions.

Plasmids will be available on Addgene in the near future!

https://t.co/Xbap6IjJfr

[MND Association @mndassoc]

Nicol Birsa is a Lady Edith @WolfsonFdn Non-Clinical Fellow.

She's interested in understanding what happens to motor neurons at the early stages of MND. Thanks to the Fellowship, Nicol hopes her research will delay disease progression and improve quality of life.

👩‍🔬 #IWD2023

[Emily Blackburn @EmilyBlackburn9]

Just under one month to go before our World Down Syndrome Day 2023 event at the Francis Crick Institute, London. We have a super exciting day lined up and it's not too late to register your place. Sign up here https://t.co/7E1zoUWi3L or email me [email protected]

[UK Dementia Research Institute @UKDRI]

Registration for the @LonDownS World Down Syndrome Day 2023 is now live!🎉

🗓️18 March
📍Francis Crick Institute, London

To register, click here👉https://t.co/Me5GMwjKiV or email [email protected]

[Oishee_Rahman @Oishee_R]

Bit of a late one but had a great time attending the Samuel Ward Careers Fair with @FergusPowell representing @BabrahamInst where we got to speak to so many students about why cell biology is exciting! Definitely made the 7am bus worth it 🤣
#publicengagement #careersinSTEM