Kelvin Cho

[tina kim @tinakim_neuro]

Twitter, it's my birthday! And there's no better gift than finally getting my job posting approved :D So please help spread the word that The Kim Lab @UCDavisCNS is hiring a research technician/lab manager! Apply below, or reach out with questions (1/2): https://t.co/YzqniJtr2G

[Manuel Leonetti @LeonettiManuel]

Endogenous tagging + 3D live-cell imaging + mass-spec interactome = https://t.co/83dtszwHs7, an open-source map of the human proteome. So excited for our first release, wonderful collaboration with @labs_mann @loicaroyer & many other colleagues. @OpenCellCZB

[Alice Ting @aliceyting]

We wrote a proximity labeling (PL) review to highlight all the exciting applications of PL to protein-protein & protein-RNA/DNA interaction mapping. See examples of PL applied to enzyme-substrate interactions, insoluble baits, dynamic PPI networks & multifunctional proteins.

[Sergiu P. Pasca @Sergiu_P_Pasca]

Today we report in @CellCellPress the most advanced #assembloid so far to build the human corticomotor pathway from stem cell-derived parts. This circuit self-assembles & cortical stimulation triggers muscle responses. Led by the amazing @jimena_andersen https://t.co/cmlHPFOcBF

[Vamsi Mootha @VamsiMootha]

Introducing MitoCarta3.0, an updated inventory of mito proteins, now w/ MitoPathway annotations and sub-compartment localization, freely available at:
https://t.co/4CskUYLjdq

[Alice Ting @aliceyting]

We’ve written a detailed step-by-step protocol for how to use TurboID (& split-TurboID) in cultured mammalian cells!

How to select your proximity labeling (PL) enzyme, design & execute PL experiments, & analyze the resulting mass spec data.

https://t.co/FCPjzNvbZy

[Alice Ting @aliceyting]

Want to try proximity labeling (PL) but don’t know how to get started? Sign up for our virtual workshop Nov 17-19! Hosted by Stanford Neuro-omics initiative. I will introduce the method and its applications, and my lab members will go through the nuts and bolts of designing &...

[Lappalainen Lab @tuuliel_lab]

Very happy and proud to present: The GTEx papers. This set of 15 papers published today describes the final phase of this 10-year effort, providing the genomics community an atlas of genetic regulatory variants and a deep dive into the biology behind it. https://t.co/hntmcfwkoH

[Villeda Lab @VilledaLab]

Very excited to share our most recent work, published today in @ScienceMagazine! @AlanaHorowitz and @ShellyFan spearheaded this study, which shows that circulating blood factors can transfer the benefits of exercise to the aged brain: https://t.co/LzMmH0dZk9

[Siavash Kurdistani @VashKurdistani]

After many long years filled w/ delight and disappointment, often in the same day, our paper on a new function of histones is out @ScienceMagazine! Thx to incredible team @NarsisAttar @OA_Campos Maria Vogelauer @jencheng65 and many collaborators.
https://t.co/c2k62462xz

[Matthias Mann Lab @labs_mann]

Enjoy our ‘Proteome Landscape of the Kingdoms of Life’ @Nature. We analyzed 100 species by #proteomics #automation #µpac #AI and doubled the number of experimentally verified proteins.
https://t.co/92SuuZhFvt

[Daniel MacArthur @dgmacarthur]

It's live! After years of work and more than 16 months in peer review, the gnomAD package is now up at Nature. We have seven papers in total, exploring different scientific aspects of this collection of more than 140,000 exomes and genomes: https://t.co/Gbq2PJwid6

[Kamila Naxerova @naxerova]

Does metastasis involve selection for specific subclones?

Lymph node mets: not so much!

Distant mets: much more so!

Check out our quantification of metastasis diversity, showing differential selection across metastatic sites in ⁦⁦@NatureGenet⁩ https://t.co/hn7OtVGACQ

[Eric Topol @EricTopol]

Just published @TheLancet
The largest study of hydroxychloroquine shows a significant increase in death (~35%) and >2-fold increase of serious heart arrhythmias. ~96,000 patients, ~15,000 on HCQ or CQ from 671 hospitals, 6 continents.
https://t.co/wl3OBKjNUs

[Arnaud Blomme @ArnBlomme]

Delighted to (finally) share our latest paper on treatment-resistant prostate cancer @HingLeung4 @CRUK_BI that is now online @NatureComms

If you like omics, metabolism, ferroptosis and a bit of ER stress, just give it a read!

https://t.co/7w0yflNr9x

[Kelvin Cho @kelvinfcho]

Our paper on split-TurboID is out @PNASNews! We reconstituted split-TurboID across ER-mito contacts and enriched >100 proteins. Thanks to @aliceyting and collaborators Steve Carr, Hyun-Woo Rhee, and In-Kyu Lee!
https://t.co/j8TrKgFukp

[Alice Ting @aliceyting]

Split-TurboID out @ PNAS! Reconstitution across mito-ER contacts in HEK IDs 101 proteins, incl. 8 novel ones we validated by MAM purification or imaging. https://t.co/HUky4SvWMG

One of my favorite figures shows intracellular split-TbID reconstitution driven by cell-cell contact:

[Alice Ting @aliceyting]

New opportunity for a lab manager/research assistant in our biochem lab @Stanford! Come join our team & work on molecular tech, optogenetics, proteomics & COVID19 diagnostics.

Ideal candidate is a senior who wants to gain research experience before applying to grad school.

[Scott Gottlieb, MD 🇺🇸 @ScottGottliebMD]

This is GAME CHANGER. Abbott to market, starting next week, a fast point-of-care #coronavirus test, delivering positive results in 5min and negative results in 13min. Will deliver 50K tests/day to start. Kudos to Abbott and FDA’s Jeff Shuren and team at CDRH who are in the fight.

[Alice Ting @aliceyting]

Split-TurboID enables conditional proximity labeling w/even greater spatial specificity than TurboID. We reconstituted split-TurboID across ER-mito contacts & enriched 101 human proteins, many of which have not prev. been linked to mito-ER contact sites.

https://t.co/uWGCTW5iwL