Oscar A Campos, PhD

UCSF Postdoc, Helen Hay Whitney Fellow #SyntheticBiology #Epigenetics #Immunotherapy

[Siavash Kurdistani @VashKurdistani]

Excited to share our latest work: L126 fine-tunes enzymatic activity of histone H3, a discovery made possible by viewing the nucleosome as an enzyme. We have a gain-of-function mutant – it’s hard to enhance an activity if it doesn’t already exist! https://t.co/RB4tEhKszU

[Oscar A Campos, PhD @OA_Campos]

Awesome!

[StarkLab @stark_lab]

We are very excited to present a major breakthrough achievement – the de novo design of synthetic enhancers for selected tissues in fruit fly embryos in vivo using deep- and transfer learning, @deAlmeida_BPet al published today in @Nature https://t.co/TIlPrBKYaK. Thread 👇(1/N)

[Oscar A Campos, PhD @OA_Campos]

@Brandon78447992 @ScienceAdvances Woohoo! Congrats Brandon! Did you try the dCas9 experiment with either direct recruitment of MBD5/6 or with SLN, as opposed to ACD15/21. It seems that MBD5/6 recruitment might perform similarly as ACD, but not SLN as it wouldn’t do the multimerization/accumulation, right?

[Mo Khalil @MoKhalilLab]

Synthetic circuits that program new capabilities into human cells have tremendous potential to expand emerging gene and cell-based therapies. Our latest work, out today in @ScienceMagazine, reports a platform to accelerate these developments: (1/n)
https://t.co/YUORpuHuZ0

[Nish Reddy @NishRReddy]

Check out our paper @ScienceMagazine. We engineered synthetic T cell circuits that locally produce the cytokine IL2. Specific configurations of IL2 circuits dramatically improved T cell clearance of solid tumors without systemic toxicity. @CDI_UCSF #SynBio https://t.co/qiZmB8IYXb

[Adam Stevens @stevenschem]

Our paper, “Programming multicellular assembly with synthetic cell adhesion molecules” is now online ahead of print.
https://t.co/UgIqmrtpJs
@nature @ucsf @CDI_UCSF @FletcherLab_UCB (and Andrew Harris), @FaranakFattahi @OphirKlein @jkgerdts @WesMcKeithanPhD

[Kyle G Daniels @ScienceKyle]

Our paper using #synbio and #MachineLearning to engineer #CARTcell signaling domains is out in Science (first release, final version is out next week).

@shangying @sara_capp @DrMilosSimic @HershBhargava @Newcolour78 @DamonRunyon

https://t.co/yNnGvGpHKp

[David Booth @dsboothacosta]

Providing trainees with higher wages and more benefits/support for childcare IS critical for making academic training possible for individuals who come for historically excluded backgrounds. And we need political and taxpayer support to accomplish this goal.

[Liam Holt @LiamHoltLab]

Finally published in eLife! “SWI/SNF senses carbon starvation with a pH-sensitive low complexity sequence”. We elucidated a new molecular mechanism by which cells detect and respond to pH-changes. Tweetorial (1/5):

https://t.co/orZJfSVuWK

With @alexholehouse @PETERSONlab

[Rogelio Hernández-López @RogelioHdezL]

🟢 My lab is opening in May! 🎊I am #recruiting at all levels to build a diverse group. Join us in discovering new biology and engineering next-gen biotechnology! #synbio #immunology #cancer #microbes Please reach out and RT to help me spread the word! 👉 https://t.co/pzpFD0M4GF

[Siavash Kurdistani @VashKurdistani]

@jencheng625 and I wrote a preview on @drbentu new cool paper on histone acetylation dynamics in response to carbon starvation in @MolecularCell Check it out!
Chromatin as a metabolic organelle: Integrating the cellular flow of carbon with gene expression https://t.co/APynF7FsJg

[Siavash Kurdistani @VashKurdistani]

Check out our new paper on how the histone H3 enzyme activity ties into Fe-S cluster biology & may contribute to pathology of Friedreich’s ataxia.
https://t.co/LMgc8Gc3l6

[Oscar A Campos, PhD @OA_Campos]

😱🥺🤞🏼

[People's City Council - Los Angeles @PplsCityCouncil]

California, 2021

[Oscar A Campos, PhD @OA_Campos]

Excited to share out newest results. We found that the histone H3 and its copper reductase function impacts cellular iron homeostasis. Our results also suggest new therapeutic strategies for #FriedreichsAtaxia #CureFA

[Siavash Kurdistani @VashKurdistani]

We’re happy to report how the histone H3 enzymatic activity and Cu(I) might underlie the pathology of a human disease. Thank you to @OA_Campos @NarsisAttar @jencheng625 M. Vogelauer and collaborators @StefanSchmolli1 @Merchant_Lab who did the work! 1/2 https://t.co/SUuscuzUrX

[Oscar A Campos, PhD @OA_Campos]

Wow! Very interesting! Cute smiley face nucleolus in Fig. 2B!

[Daria Amiad Pavlov @AmiadDaria]

It is out! Delighted to share our @ScienceAdvances paper on the surprising #chromatin organization in the live muscle nuclei (but not only). With @TalilaVolk, @DanaLorber, and @WeizmannScience collaboration with the Samuel Safran and Ronen Alon groups.
https://t.co/s3RmvUvWuV

[Oscar A Campos, PhD @OA_Campos]

@IchinoLucia @SJacobsenUCLA Glad to see it finally came out, congrats!

[Oscar A Campos, PhD @OA_Campos]

Super interesting, love the evolutionary genome structure comparison. Also, wow Fig 1! Data becomes art. 3D genomics across the tree of life reveals condensin II as a determinant of architecture type https://t.co/cTzzJkOUQU

[Oscar A Campos, PhD @OA_Campos]

The microbiome and human cancer https://t.co/RV163wVYXT

[Oscar A Campos, PhD @OA_Campos]

Super cool! Elegant mechanism to control population size of differentiating cells.

[KuehLab @Kueh_Lab]

Finally – it’s out!! Thrilled about our new paper, on a timed epigenetic switch controlling the T-cell fate decision. This study was co-led by the dynamic experiment/theory duo @nickApease and Sam Nguyen. (1/n)

https://t.co/84W1NWTJ9a

[Michael 英泉 Eisen @mbeisen]

I’ve had honor of teaching & mentoring many CSU students in my 20 years at UC. They are amazing. We could fill every NSF slot w/CSU grads and the only thing you’d notice is that science would be more diverse and dedicated, and half of every grad class would say Hella a lot.