Cell Design Institute @UCSF

Official Account of the Cell Design Institute @UCSF. Bringing a unique foundational approach to cell therapies.

[Cell Design Institute @UCSF @CDI_UCSF]

We are hiring Junior Specialists (pre-PhD level) for variety of cell engineering and synthetic biology projects. Our trainees have gone on to PhD, MD, and industry positions at @UCSF, @Harvard, @sonomabio, @genentech, @ArsenalBio, @UCSD, etc!

Apply Here: https://t.co/c2Ruoe3Fp6

[Cell Design Institute @UCSF @CDI_UCSF]

Please RT! We are hiring Junior Specialists (pre-PhD level) for variety of cell engineering and synthetic biology projects. Our trainees have gone on to PhD, MD, and industry positions at @UCSF, @Harvard, @sonomabio, @genentech, @ArsenalBio, @UCSD, etc!

https://t.co/QBhKXyUG2m

[Cell Design Institute @UCSF @CDI_UCSF]

Congratulations Adam!!

[Adam Stevens @stevenschem]

I am excited to announce that in March, I will start my lab in the Department of Cancer Biology (@Penn_CBIO) at the University of Pennsylvania Perelman School of Medicine (@PennMedicine). https://t.co/HSnFEBRF9C

[Cell Design Institute @UCSF @CDI_UCSF]

@TrevorCampbell_ @NishRReddy @ScienceMagazine Check out https://t.co/HGkBsXDdC3

[Immunology Podcast @ImmunoPodcast]

New from Drs. @NishRReddy, Wendell Lim, and others at @CDI_UCSF!

They engineered human T cells to make a synthetic receptor recognizing overactive T cells that can #AutoimmuneDisease and #OrganRejection.

📃@ScienceMagazine: https://t.co/n4GYlomqD9
🎧: https://t.co/bD1TdF85wC

[Adam Stevens @stevenschem]

Congratulations Toshi and Coralie!

[DrMilosSimic @DrMilosSimic]

Check out our latest work on building “smart cells” with a tissue GPS to precisely treat some of the most challenging diseases without off-target toxicity.
Brain targeting: https://t.co/IfJxRj0qUz
T cells with new immunosuppressive functions:
https://t.co/5xV69x7R0X

[Cell Design Institute @UCSF @CDI_UCSF]

Congratulations to all collaborators and thank you to our funders: @stevenschem @OphirKlein @benoitbruneau @PetrKaspareksci @jbrunger @NIH @NIGMS @Yini_Xiao

[Cell Design Institute @UCSF @CDI_UCSF]

The latest from Lim Lab at CDI out today in @CellCellPress! "Synthetic organizer cells guide development via spatial and biochemical instructions" led by star postdocs Toshi Yamada (@ToshimichiY) and Coralie Trentesaux

https://t.co/20E2W0VgBi

[Cell Design Institute @UCSF @CDI_UCSF]

Toshi and Coralie engineered synthetic organizer cells that programmably send signals to developing embryos in vitro. They observe highly ordered beating heart like structures, and show how organizer cells can direct sophisticated developmental assemblies!
https://t.co/1PScAHb2I5

[UCSF Neurosurgery @NeurosurgUCSF]

.@UCSF scientists have developed a “molecular GPS” system that makes it so that T cells can target and attack brain tumor cells without harming healthy tissue: https://t.co/HLgYfdeOa8
https://t.co/qLJZsOzbuO
@OkadaLabUCSF1 @CDI_UCSF @DrMilosSimic @UCSFCancer @ScienceMagazine

[Hasna Maachi @MaachiHasna]

Thrilled to share our latest collaborative work with the Lim Lab, it has been an incredible journey that wouldn’t have been possible without the creativity and dedication of everyone. THANKS TO THE TEAMS @NishRReddy @CDI_UCSF @HebrokLab @AParent_lab @lillian_xyn @AtUcsf et al 🎉

[Hersh Bhargava @HershBhargava]

HUGE congratulations to my labmates @NishRReddy and @DrMilosSimic!! Making waves so big we almost had a tsunami today 🌊

[Science Magazine @ScienceMagazine]

An engineered T cell (center) is designed to deliver therapies to the brain. This T cell displays orange synthetic receptors on its surface, which recognize components of extracellular matrix fibers that are only found in the brain. Within the cell, downstream signaling pathways are programmed to initiate transcription and release a therapeutic payload—shown as light blue protein secretions.

Learn more in this week's issue of Science: https://t.co/j2m8CBtVwK

[UC San Francisco @UCSF]

Bravo to Wendell Lim, PhD, and team for making the cover of @ScienceMagazine! The team armed immune cells with “molecular GPS” to find and treat brain cancer, MS and type I diabetes. Clinical trials could begin as soon as 2025. @CDI_UCSF @ARPA_H @theNCI
https://t.co/4z5gMVfimN

[Cell Design Institute @UCSF @CDI_UCSF]

This work wouldn't be possible without the support of our funders and institutions including @AtUcsf @parkerici @UCSF @NIH @NIDDKgov @HIRN_CC @theNCI @NINDSfunding @ARPAHealth @ValhallaFound @UCSFCancer et al!

[Cell Design Institute @UCSF @CDI_UCSF]

Big news today: 2 papers and the cover of @ScienceMagazine!

@NishRReddy et al. built T cells that suppress inflammation in specific tissues https://t.co/Awyc75vZbI

@DrMilosSimic, Payal Watchmaker et al. built T cells that deliver therapies to the brain https://t.co/dAx0OQURBV

[Cell Design Institute @UCSF @CDI_UCSF]

Huge congratulations to all authors, including @NishRReddy @DrMilosSimic @HebrokLab @AParent_lab @MaachiHasna @Yini_Xiao @OkadaLabUCSF1 @OlgaTroyanskaya @AllenLabAtUCSF @Yuweiba2 et al!