ule_lab

Welcome to the RNA networks lab! @TheCrick and @UKDRI at King's in London and @kemijski in Ljubljana 🇪🇺

[gagneurlab @gagneurlab]

Honoured to have written this review with Jernej Ule’s lab on the splicing code, spanning modeling, mechanisms and its implication for therapeutics designs. Wonderful teamwork.

[Miha Modic @paraspeckle]

How can cellular signalling swiftly & selectively remodel the transcriptome to drive biological transition? How this switch is orchestrated has been a mystery... 🧵

https://t.co/3z4dcVoztD

[Miha Modic @paraspeckle]

An opinion piece on how phosphorylation of intrinsically disordered domains selectively alters global protein–RNA binding profiles.

https://t.co/uYgp0YswvA

[UK Dementia Research Institute @UKDRI]

💡Opportunity for a Lab Technician to join Prof Jernej Ule's lab (@ule_lab)!

Join Dr Owen G. James (@owengwydz) and a team of researchers working on the roles of ribonucleoprotein complexes (RNP) and their defects in neurodegeneration👉https://t.co/JtzmelYk8v

[ule_lab @ule_lab]

So excited to share our work on RNA motifs in CLIP, which is published here https://t.co/Qc3ZbdlXfk! Read more from @KlaraKuret here: https://t.co/9N5M3cREj4.

[ule_lab @ule_lab]

@liamfaller Congrats Liam and team, really impressive how you could unravel ribosome heterogeneity from Ribo-seq data so well! This will be increasingly useful as more data emerges.

[TheSibleyLab @TheSibleyLab]

Last few days to go.... please RT

[Oscar Wilkins @OscarWilkins16]

Great opportunity to join our team (@FrattaLab) working on an innovative new gene therapy for ALS/FTD. A mix of novel computational (incl. new machine-learning approaches), molecular & cellular biology, all with a real therapeutic aim. Get involved! Link: https://t.co/AooShrypK8

[ule_lab @ule_lab]

I feel so lucky to join the wonderful community of researchers at UKDRI!

[UK Dementia Research Institute @UKDRI]

It is a pleasure to announce that our new Centre Director for UK DRI at King’s is Prof Jernej Ule (@ule_lab), an expert in RNA biology and its role in neurodegenerative diseases such as ALS/FTD 🥳🎉🧠

Read more 👉 https://t.co/PSvxadJCRy (1/4)

[ule_lab @ule_lab]

Great to have been involved in this study, led by @FrattaLab and @wardm50, now in Nature! Featuring lab members @OscarWilkins16, plus iCLIP data (of course!) from @fcylee and @martinahallegg1. Hopefully this can pave the way to effective precision medicine https://t.co/5iEmvGL1Vm

[Charlotte Capitanchik 🌙 @tiny_captain]

Wahoo!! Read on for some v. cool insights into how YTH proteins function... in yeast the lone YTH protein is loaded at chromatin & travels to cytoplasm where it helps to couple decay of targets to active translation 👯‍♀️

[Faraz K Mardakheh @FKHM]

Check out our latest preprint entitled “An RNA-binding switch drives ribosome biogenesis and tumorigenesis downstream of RAS oncogene”, out now on @biorxiv:
https://t.co/687XYatOvM

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[ule_lab @ule_lab]

Congrats Sina! Very valuable findings and new methods SPACE and SPACEmap to isolate chromatin components and identify the chromatin-contact regions with high sensitivity.

[Sina Rafiee @SinaRafiee_bio]

Chromatin-contact atlas reveals disorder-mediated protein interactions and moonlighting chromatin-associated RBPs https://t.co/u7qcSdIsKo

[ule_lab @ule_lab]

This is the first manuscript fully done by the Ljubljana satellite of the RNA networks lab! Originated by Aram
@amalietti
, an incredible software developer who wrote the code, and then taken over by Klara, a PhD student. Real honour working with such talents!

[ule_lab @ule_lab]

@KlaraKuret @biorxivpreprint This is the first manuscript fully done by the Ljubljana satellite of the RNA networks lab! Originated by Aram @amalietti, an incredible software developer who wrote the code, and then taken over by Klara, a PhD student. Real honour working with such talents!

[ule_lab @ule_lab]

@SinaRafiee_bio Congrats Sina! Very valuable findings and new methods SPACE and SPACEmap to isolate chromatin components and identify the chromatin-contact regions with high sensitivity.

[Sina Rafiee @SinaRafiee_bio]

Chromatin-contact atlas reveals disorder-mediated protein interactions and moonlighting chromatin-associated RBPs https://t.co/u7qcSdIsKo

[NOVA Medical School, Faculdade de Ciências Médicas @nova_medschool]

TODAY, 12h, for our #CEDOCSeminar we will have @PauloGameiro8 from @ule_lab @TheCrick to talk about "Metabolism & RNA modifications in gene regulation". 🧑‍🔬👨‍🏫

Don't miss it! DM us for the Zoom link 📬🙌

[Paulo Gameiro @PauloGameiro8]

@ule_lab
https://t.co/g56ZJhcbi1

Latest, a 13C-based assay to quantify the turnover of base modifications in newly transcribed RNA, by mass spectrometry.

We uncover the origin of RNA modifications in digested RNA, and assess their sensitivity to metabolic stresses.

[Tajda Klobucar @KlobucarTajda]

After an extremely long time, members of @ule_lab are enjoying an in-person conference in Vienna @viennabiocenter. What a feeling! 🤗 @paraspeckle @martinahallegg1