Much of the success of breakthroughs, such as AlphaFold, is thanks to a database of protein structures dreamed up in the 1960s by Helen Berman https://t.co/j7l4MJ5OeU
To launch this collection the following #Review is free to download for 1 month:
From computational models of the splicing code to regulatory mechanisms and therapeutic implications https://t.co/94P3YXVUid by @tiny_captain, @OscarWilkins16, @nils_f_wagner, @gagneurlab & @ule_lab
Our paper on cryptic splicing-controlled protein expression, which we hope will inspire safer and more adventurous gene therapy approaches for ALS and FTD, has been published in @ScienceMagazine https://t.co/YriG3I4ILF
We are finally here. Thanks to @OscarWilkins16 and @FrattaLab gave me this wonderful chance to participate in this fantastic research.
Creation of de novo cryptic splicing for ALS and FTD precision medicine | Science https://t.co/8fI2NKngcu
Hot on the heels of the review comes @OscarWilkins16 beautiful work in @ScienceMagazine describing a new therapeutic approach for ALS designed using SpliceAI to implement directed in silico evolution https://t.co/5vtgsnfE1L
Honoured to have written this review with Jernej Ule’s lab on the splicing code, spanning modeling, mechanisms and its implication for therapeutics designs. Wonderful teamwork.
in this article we delve into the world of splicing models! i specifically focused on the latest omics technologies that will help us to interpret and train models, looking towards future opportunities. lots of biorxiv citations because the field is moving so fast!!!
was very fun to work with @nils_f_wagner and @gagneurlab on this and also a great opportunity to highlight @OscarWilkins16's awesome work designing therapeutics using splicing models
🚨The Briscoe lab are hiring! Apply by Oct 9 to:
• build custom single-cell technologies to study dev bio
• collaborate on projects spanning cancer therapy, immune profiling and neurodegenerative disease
• learn valuable skills for academia or industry
https://t.co/e6AWFJqjiB
School’s back and so are we with another co-working session and social!
This time we’ll be at the @SGDPCentreKCL, with the social being opened up to all ECR’s within the centre 😎
As always, free 🍕 and 🍻🥤
https://t.co/GqtND4xrjB
How can cellular signalling swiftly & selectively remodel the transcriptome to drive biological transition? How this switch is orchestrated has been a mystery... 🧵
https://t.co/3z4dcVoztD
I'm excited for whoever will employ @kittybmurphy - she's an incredible computational geneticist and will be the most amazing addition to any team she joins. Super proud to see this superstar student move on and develop her academic career 🥰