I am very excited that my first first-author paper is now out at @NatureComms ! We discovered a biphasic infiltration of neutrophils into the injured neonatal brain with dichotomous functions! 🧵 below (1/11): https://t.co/EKtjP2sPam
Excited to share our new paper in Arteriosclerosis, Thrombosis, and Vascular Biology:
CCR2⁺ Neutrophils Exhibit a Proinflammatory Phenotype and Contribute to Plaque Vulnerability
https://t.co/ynXLVzcctw
A new Science #Immunology study in mice shows that persistent inflammatory stress and type I #interferon signaling generates splenic #neutrophils with specialized antibacterial functions, helping clear bladder infections. https://t.co/g8ETCV3d0r
This project first grew as an idea between Sebastian and me from very different perspectives, turned into a pilot project of @CRC_TRR332, and is now finally published. We believe this approach opens up exciting opportunities to bring single-cell lipidomics into immunology.
Using a cell-tracker approach, we were also able to analyse patient and control neutrophils on the same slide. This allows for batch-free comparisons within experiments and robust batch correction across experiments while preserving biological variation.
A distinct wave of neutrophils recruited to brain injury site promotes repair
📷 Mathis Richter & Eva Diesterbeck et al @unidue in @NatureComms
➡️ https://t.co/aArjQVJegQ with @AntDLewis
Today, we see the fruit of 5+ years of teamwork. We have built a map of the neutrophil compartment (mostly in mice - but also humans). It provides a biological structure that focuses on a single immune cell lineage to discover the many ways in which neutrophils to physiology.
This is one of the best papers of 2025, a definitive resource to map, visualize and ultimately understand the logic of neutrophils. So happy to see such massive achievement by amazing scientists and human beings @ivanbamartin@AndrsHidalgo16@lai9uan
https://t.co/yD5H5FhMph
I’m thrilled to introduce you to the NeuMap! our latest work in @Nature. A global, comprehensive, single-cell transcriptional atlas of neutrophils across 47 biological conditions in human and mice. A real tour-de-force 🗺️ @AndrsHidalgo16 https://t.co/W8X6eOUsKc
Are you looking for a PhD student position focussing on neuro-immunology of peripheral nerves? Apply here to work with us in Münster: https://t.co/jRpzKm2Fw5
Congrats Mathis and Josephine: Hypoxic-ischemic brain injury in neonatal mice sequentially recruits neutrophils with dichotomous phenotype and function | Nature Communications https://t.co/Zxrq8Am2ns
We started this work in my master thesis with Josephine Herz @MedEssen and finished it in a great team effort during my time @soehnleinlab. Thank you to everyone involved including Eva, the rest of the team and our collaborators incl. @pylaeva_e@JagaJablonska@GunzerLab. (11/11)
I am very excited that my first first-author paper is now out at @NatureComms ! We discovered a biphasic infiltration of neutrophils into the injured neonatal brain with dichotomous functions! 🧵 below (1/11): https://t.co/EKtjP2sPam
In summary, we found that neutrophils infiltrating the injured neonatal brain acquire a disease-stage dependent reprogramming leading to either a detrimental or pro-regenerative state. (10/11)