Robin van Schendel

C. elegans lover, devoted researcher and programmer, father of three

[Robin van Schendel @RobinVSchendel]

5/5 Thanks to Ron Romeijn, Lejon Kralemann, Paul Hooykaas, and Marcel Tijsterman for leading this work — and to the Jacob lab for the great parallel story! #DNARepair #GenomeStability #Genomics #TMEJ #TandemDuplication

[Robin van Schendel @RobinVSchendel]

1/5 🧬 New paper in @NatureComms! We identified TONSL/TONSOKU as a cross-kingdom suppressor of large tandem duplications (TDs) in cancer — and we mean LARGE: ~25 kb to ~500 kb!
👉 https://t.co/YwexnYMQu8

[Robin van Schendel @RobinVSchendel]

4/5 🤝 Back-to-back with the lab of Yannick Jacob (@YannickJacobLab), who independently found the same TD phenotype in Arabidopsis and links it to ATR–WEE1 checkpoint activation:
👉 https://t.co/NywbevhXvy

[Math Files @Math_files]

During World War II, the U.S. military studied bullet holes on returning planes to decide where to add armor. Most damage appeared on the fuselage, so many thought it should be reinforced.

Mathematician Abraham Wald pointed out a crucial flaw: the data only showed surviving planes. Planes hit in the engine didn’t return at all. This meant the engine was the real weak point.

By reinforcing engines instead, many more planes were saved.
The lesson: good mathematics isn’t just about numbers—it’s about questioning assumptions behind the data.

[David R. Liu @davidrliu]

Today in @Nature we report a new prime editing strategy that can rescue a common cause of many genetic diseases in a disease-agnostic manner. This approach converts a redundant endogenous tRNA into an optimized suppressor tRNA, enabling a single prime edit to rescue premature stop codons across different diseases.
(1/15)
https://t.co/zs0qu5bhXx

[EDRA (European DNA Repair Alliance) @EDRA_Webinars]

We’re thrilled to host Françoise Dantzer, presenting on PARP3 and its roles in DNA repair, cell plasticity, and cancer. Marco Baraza (M.Tijsterman lab) will share insights on MUSIC, a genome-wide CRISPR screen revealing DSB repair signatures. Still one slot available! (06/24/25)

[Robin van Schendel @RobinVSchendel]

@SerenaNikZainal @NatureGenet @GeneChChKoh Looks great! I like InDels much more than SNVs anyway. We have found some funky InDels in worms in some backgrounds and I hope that your new signatures will shed some more light on that as well. Congratulations to the entire team!

[Robin van Schendel @RobinVSchendel]

@_adameur I think if you want to call mutations from single reads this is still very difficult with long read sequencing. If you are talking about SNVs or indels by using multiple reads I am sure that will be possible. HiFi reads are indeed already more usable for that purpose.

[Robin van Schendel @RobinVSchendel]

@LarsBoelen @FCCoachJohan Ik dacht dat dit niet mag zonder vergunning? Omdat alleen daken zijn vrijgesteld hiervan. En dat je voor dit soort opstellingen een non-reflecterend paneel moest hebben? Ik vraag het omdat ik zo een optie eerder ook overwoog.

[Eric Betzig @Eric_Betzig]

DAPI-stained nuclei in an L1-stage C. elegans larva, as seen by two-photon Bessel beam structured plane illumination microscopy. https://t.co/xE9P8ABIw9

[The Ocean Cleanup @TheOceanCleanup]

We have just completed the last trip to the Great Pacific Garbage Patch for 2024, resulting in our total catch of over 500,000 kg (1.1m lb) from the GPGP so far.

Here are some facts about our ocean operations to date:

[Robin van Schendel @RobinVSchendel]

@ItaiYanai I needed that!

[Robin van Schendel @RobinVSchendel]

Very interesting work that our lab has contributed a bit to. Check it out and let us Know what you think!

[Michael Kosicki @michaelkosicki]

Updated manuscript! We analyzed Cas9-generated indels at >2,800 synthetic Cas9 targets in 18 DNA repair deficient stem cell lines to learn about sequence-specific DNA repair. #GeneEditing #Cas9 #DNArepair Soon to be out! https://t.co/buirEQ021t

[Michael Kosicki @michaelkosicki]

Updated manuscript! We analyzed Cas9-generated indels at >2,800 synthetic Cas9 targets in 18 DNA repair deficient stem cell lines to learn about sequence-specific DNA repair. #GeneEditing #Cas9 #DNArepair Soon to be out! https://t.co/buirEQ021t

[Robin van Schendel @RobinVSchendel]

@CaronPierre13 @GeflucGrenoble That's great news Pierre! Congratulations!

[Robin van Schendel @RobinVSchendel]

@Roel_vdHeijden @UitgeverijUBHS Wat gaaf! Veel succes!

[Robin van Schendel @RobinVSchendel]

@SusanKilgas @NatureComms Neat! Will check it out later. Congratulations!