Ross Firestone

Physician scientist @MSKCancerCenter via @DOMSinaiNYC @einstein_mstp

[Francesco Maura @FrancescoMaura4]

Together with @RossFirestone and @szusmani
we are happy to share our thoughts on SUCCESSOR-2 clinical trial published few days ago on @TheLancet
#mmsm #mezigdomide @MSKCancerCenter @MSK_DeptOfMed https://t.co/P9RS5pWPFI

[Robert Z. Orlowski @Myeloma_Doc]

#Myeloma Paper of the Day: A differentiated T-cell repertoire (CD8+CD45RA+CD62L-CCR7- T effector cells re-expressing CD45RA (TEMRA)) may define a functionally high-risk group (median time to progression of 2.1 years) of smoldering myeloma patients: https://t.co/BoPy7vLiZW. #mmsm

[OncoDaily @oncodaily]

Myeloma Paper of the Day, August 26th, Suggested by Robert Orlowski (@Myeloma_Doc)

@RossFirestone @DrOlaLandgren @szusmani @LesokhinMD

https://t.co/y0GurL2CIo

#OncoDaily #Oncology #Cancer #Health #Medicine #MedTwitter #MedEd #MedOnc #MedNews #MM #Myeloma @CancerWorldmag

[Robert Z. Orlowski @Myeloma_Doc]

#Myeloma Paper of the Day: Immune-MRD status informs tumor-MRD outcome prognostication in myeloma pts on Len maintenance; T cell profiles enriched w/ activated cytotoxic effectors predict early relapse & quiescent/naïve T-cells predicting remission: https://t.co/SRc8quQNts. #mmsm

[Francesco Maura @FrancescoMaura4]

It was fun to work with @RossFirestone in writing this editorial for @BloodPortfolio #Blood "More than myeloma: the trouble with “normal” plasma cells", on the recent article from @nickbolli @matteoclaudio84 https://t.co/f7vtz1Dn8W @MSKCancerCenter @MSK_DeptOfMed #mmsm

[Anish Simhal @aksimhal]

1/ 🚨New research alert! 🚨Our study in @BloodCancerJnl shows that high WEE1 expression is an independent predictor of poor survival in multiple myeloma (MM), with @RossFirestone, @MalinHultcrantz, @LarryNortonMD, @szusmani, and the rest of the @MSKCancerCenter team! 🧵👇

[Blood Journals Portfolio @BloodPortfolio]

Therapy–mediated BCMA expression loss after belantamab or anti-BCMA chimeric antigen receptor T cells underlies teclistamab failure in RRMM. https://t.co/F4EnveJMjm #lymphoidneoplasia #immunobiologyandimmunotherapy #multiplemyeloma

[Ross Firestone @RossFirestone]

Thanks to the investigators and to our patients for help with this work! 7/7

[Ross Firestone @RossFirestone]

Our work with @szusmani and @DavidJChungMD at @MSKCancerCenter looking at antigen escape with BCMA-targeting therapies in #MMSM patients is now out in @BloodJournal https://t.co/GCMzIIJoDh 1/7

[Ross Firestone @RossFirestone]

We also found that, at times of active disease, low or undetectable levels of soluble BCMA reported on expression loss, offering a noninvasive method to test BCMA expression in clinical practice settings 6/7

[Ross Firestone @RossFirestone]

We also can't ignore that remote healthcare utilization is part of the patient experience. Portal messages and phone calls, while not as burdensome as in-person visits, are important signals of patient unease. #rUHI 6/6

[Ross Firestone @RossFirestone]

Conclusion: We need to do a better job preparing patients for the expected complications of BsAb and CAR T therapies (both major and minor) to avoid unnecessary healthcare interactions and improve QoL, while still keeping patients safe. 5/6

[Ross Firestone @RossFirestone]

Notably, unscheduled interactions rarely altered treatments plans, and patients almost always went home from in-person visits without care escalation. 4/6

[Ross Firestone @RossFirestone]

In this study we looked at unscheduled healthcare interactions in MM patients receiving CAR T or BsAbs, with a focus on remote interactions. We found that healthcare utilization was high, even in patients responding well to treatment. 2/6

[Ross Firestone @RossFirestone]

Remote and in-person healthcare utilization was higher in BsAb patients, seemingly due to an increased incidence of low-risk infections (URIs, etc). 3/6

[Ross Firestone @RossFirestone]

Excited to see our manuscript on healthcare utilization in CAR T and bispecifics patients with #MMSM in press! This work was spearheaded by Anna Howard RN and @isabelconcepci MSN FNP-C. https://t.co/AZNTGE2ksd 1/6