Roy Novoselsky

[OncoDaily @oncodaily]

Extracting Sub-cellular mRNA Polarization in Tissues via Image Processing - Shalev Itzkovitz

@SItzkovitz @RoyNovoselsky @OfraGolani

https://t.co/u6t5WP1n3R

[shalev itzkovitz @SItzkovitz]

Check out @RoyNovoselsky and @OfraGolani new paper in @NatureComms: https://t.co/MzM6MnOD4h. We combine image processing and spatial transcriptomics to extract sub-cellular mRNA polarization in tissues. @WeizmannScience.

[Weizmann Institute @WeizmannScience]

A first-of-its-kind genetic atlas from Prof. @SItzkovitz's group reveals how human liver cells divide their labor - and why some regions are especially vulnerable to fatty liver disease >> https://t.co/MEUNXm1nLO @SHEBA_ @MayoClinic @Nature

[shalev itzkovitz @SItzkovitz]

Our paper on zonation in the truly healthy human liver is out in @Nature: https://t.co/I4Mjpnl8Pe
Acquisition of healthy human tissues for cell atlas studies is challenging. The regenerative capacity of the human liver enabled analysis of tissues from living organ donors.

[Biton Lab @bitonslab]

Check out our latest pre-print on @biorxivpreprint ! We show that the intestinal MHC II self-ligandome is spatially compartmentalized across villus, crypt, and immune niches, and is dramatically rewired during injury toward damage-associated self-antigens.
https://t.co/j9lKSXVI35

[shalev itzkovitz @SItzkovitz]

Happy to share our new paper: Transcriptomics of upper gastro-intestinal fluids can diagnose pancreatic ductal adenocarcinoma https://t.co/nddJC3VVl0.
The upper GI tract constantly sheds cells. We asked if PDAC-induced systemic changes alter shedding patterns.

[shalev itzkovitz @SItzkovitz]

Happy to share our new preprint: Spatial Rewiring of Enterocyte Identity in Celiac Disease https://t.co/tfw3wD6Lsr. We describe unexpected changes in enterocyte zonation in Celiac Disease.

[shalev itzkovitz @SItzkovitz]

Happy to share our new preprint: Subcellular mRNA localization patterns across tissues resolved with spatial transcriptomics: https://t.co/ejJMnMaYQF
We utilize VisiumHD to extract intra-cellular mRNA polarization patterns in epithelial tissues.

[bioRxiv SysBio @biorxiv_sysbio]

Subcellular mRNA localization patterns across tissues resolved with spatial transcriptomics https://t.co/eq08m5GeGn #biorxiv_sysbio

[shalev itzkovitz @SItzkovitz]

Congratulations @RoyNovoselsky on your new study in @PLOSBiology exploring mRNA and protein polarization across the human intestinal epithelium: https://t.co/91DBseWgz7.

[PLOS Biology @PLOSBiology]

Both proteins & mRNAs have apicobasal polarization in mouse #intestinal epithelium. Study of human intestinal cells by @RoyNovoselsky @SItzkovitz &co shows that while mRNAs are similarly polarized, human #mitochondria & #ribosomes are less so #PLOSBiology https://t.co/P8LaL2wYWM

[shalev itzkovitz @SItzkovitz]

Happy to share our paper online today in @Nature: A spatiotemporally resolved single cell atlas of the Plasmodium liver stage. https://t.co/oMUUioYmfo. Wonderful collaboration with @MariaMMota2 led by @AfriatAmichay.