Ruchi

[Ruchi @RuchiSane]

#OTILT gauze can cause false positives in Beta D Glucan tests by releasing glucan @armandbak @BWDionne @jeffpears0n @davidwkubiak https://t.co/fLJ7bI01CR

[Ruchi @RuchiSane]

#OTILT community acquired vs hospital acquired MRSA represent two different strains. Community acquired MRSA has become the more dominant strain in recent years. @armandbak @BWDionne @jeffpears0n @davidwkubiak https://t.co/EArch4KS93

[Ruchi @RuchiSane]

#OTILT is the ARREST trial found that adding on rifampin in Staph aureus bacteremia had no impact on clinical outcomes except for a reduction in recurrence @armandbak @BWDionne @jeffpears0n @davidwkubiak https://t.co/YBugYogaEt

[Ruchi @RuchiSane]

#OTILT 30% of antibiotic resistance genes can be found in soil, including a vanco resistance gene that was discovered in the tundra @armandbak @BWDionne @davidwkubiak @jeffpears0n https://t.co/9BUY2t5eQf

[Ruchi @RuchiSane]

#OTILT is Hep C antibodies are not protective, meaning re-infection is possible. Certain populations are at a higher risk of re-infection. @armandbak @BWDionne @jeffpears0n @davidwkubiak https://t.co/xmbehTKB2R

[Ruchi @RuchiSane]

#OTILT is that colonization by Clostridium spp. can compete with other Clostridium spp. which could potentially prevent infection @armandbak @BWDionne @jeffpears0n @davidwkubiak https://t.co/d7YbXTfBZK

[Ruchi @RuchiSane]

#OTILT voriconazole was found to be superior to amphotericin B in the treatment of invasive aspergillosis @armandbak @BWDionne @jeffpears0n @davidwkubiak https://t.co/PaTQkaPx7v

[Ruchi @RuchiSane]

#OTILT is use of parenteral antibiotics can sterilize CSF very rapidly (as soon as 15 minutes after administration for meningococcal!) making it important to culture CSF before treating if possible @armandbak @BWDionne @davidwkubiak @jeffpears0n https://t.co/VYhvXEGITB

[Ruchi @RuchiSane]

#OTILT methenamine needs acidic urine to be converted to formaldehyde to kill bacteria. Ascorbic acid can be used to try to acidify the urine to increase the efficacy of methenamine. @armandbak @BWDionne @jeffpears0n @davidwkubiak https://t.co/szDl5l8XAj

[Ruchi @RuchiSane]

#OTILI Candida parapsilosis is a species of fungi that has become increasingly more prevalent in infections in recent years. It can be treated with azoles, amphotericin B, or echinocandins.
@armandbak @BWDionne @jeffpears0n @davidwkubiak https://t.co/5oceaNpPtZ

[Ruchi @RuchiSane]

#OTILT loading normal saline before liposomal amphotericin B may be beneficial as a way to resolve AKI in patients @armandbak @BWDionne @jeffpears0n @davidwkubiak
https://t.co/D0s1Ui4JhE

[Ruchi @RuchiSane]

#OTILT is piperacillin/tazobactam is not typically used in CNS infections due to each drug component having different levels of CSF penetration due to each one's PK parameters @armandbak @BWDionne @jeffpears0n @davidwkubiak https://t.co/9xIAIOkXML

[Ruchi @RuchiSane]

#OTILT is that multidrug resistant tuberculosis is defined as being resistant to isoniazid and rifampin. New testing can detect MDR TB mutations so patients can be started on appropriate therapy immediately @armandbak @BWDionne @davidwkubiak @jeffpears0n https://t.co/OZuBHpttFM

[Ruchi @RuchiSane]

#OTILT in intra-abdominal infections after achieving source control the outcomes for shorter courses (~4 days) of antibiotics were similar to longer courses (~8 days) @armandbak @BWDionne @jeffpears0n @davidwkubiak https://t.co/T0lsS2nFNL

[Ruchi @RuchiSane]

#OTILT is the Karius test can detect nucleic acid in a sample that can be used to identify pathogens and lead to a diagnosis @armandbak @BWDionne @davidwkubiak @jeffpears0n https://t.co/qcXr5tRXNT

[Ruchi @RuchiSane]

#OTILT dalbavancin has an incredibly long half life so it can be dosed one time to stay active for the typical 6 week endocarditis treatment duration making it a useful treatment option @armandbak @BWDionne @davidwkubiak @jeffpears0n https://t.co/D2CZ0OrNEh

[Ruchi @RuchiSane]

#OTILT nutritionally variant strep species require pyridoxal agar to grow in cultures and have high rates of beta lactam resistance @armandbak @BWDionne @davidwkubiak @jeffpears0n https://t.co/X9n58MYmUb

[Ruchi @RuchiSane]

#OTILT fluconazole can inhibit the activity of amphotericin B when given in combination. Fluconazole inhibits ergosterol synthesis and amphotericin B relies on ergosterol to bind to exert its effect. @armandbak @BWDionne @jeffpears0n @davidwkubiak https://t.co/Q4BEUggXij

[Ruchi @RuchiSane]

#OTILT is there is data supportig the use of beta lactam monotherapy is noninferior to beta lactam + macrolide therapy https://t.co/WWsRNY9pt0 @armandbak @BWDionne @jeffpears0n @davidwkubiak

[Ruchi @RuchiSane]

#OTILT Enterococcus gallinarum has intrinsic vancomycin resistance making it an inappropriate choice of therapy https://t.co/PceN5zrdLq @armandbak @BWDionne @jeffpears0n @davidwkubiak