@charliekirk11 Improved is subjective. You’re basing your information of an influx of refugees who have nothing. In our history people have always criticized new immigrants but later we look back and find benefits they gave our society by immigrating. You’re being an ignorant bigot(shocker)
#OTIL is that when MRSA strains develop resistance to daptomycin they decrease in resistance to β-lactams. The use of dapto and β-lactams in combo prevents the selection of dapto resistant strains.
@ruchisane@BWDionne@jeffpears0n@davidwkubiak https://t.co/iC3lbyXPfT
#OTIL is that colistin is the approved by the FDA for intrathecal administration. Other Abx have been administered intrathecally but this is an off-label use.
@armandbak@BWDionne@jeffpears0n@davidwkubiak https://t.co/0im35Al2RD
#OTIL is that C. albicans has the lowest rate of resistance to fluconazole out of the Candida spp. but since it is the most common out of the Candida spp. it also has the most amount of resistant isolates.
@armandbak@BWDionne@jeffpears0n@davidwkubiak https://t.co/0vAmsFe8CH
#OTIL is that moxifloxacin has a more potent prolonged QTc effect compare to other FQs. This increases the pts risk for developing torsades.
@armandbak@BWDionne@jeffpears0n@davidwkubiak https://t.co/1b1OHZBmkW
#OTIL is that Candida glabrata is dose depend susceptible to fluconazole. This means that we have to dose fluconazole at a higher dose, like 800 mg q 24 hrs, to meet the AUC/MIC threshold
@armandbak@BWDionne@jeffpears0n@davidwkubiak https://t.co/r7kPRbqa0T
#OTILT is that there are individuals who are considered "elite controllers". These individuals have suppressed viral loads to levels that are undetectable without antiretroviral therapy.
@RuchiSane@BWDionne@jeffpears0n@davidwkubiak https://t.co/4mj1cPjPFM
#OTILT is that Candida spp. colonization is extremely common inside the respiratory tract. Cultures will likely come back positive but it is unlikely to be a true infection
@RuchiSane@BWDionne@jeffpears0n@davidwkubiak https://t.co/qpR7NzVNVq
#OTILT is that dexamethasone can be used in bacterial meningitis before the first dose of Abx to improve pt outcomes and mortality.
@RuchiSane@BWDionne@jeffpears0n@davidwkubiak https://t.co/yz79z7s8Yu
#OTILT is that the data regarding FTC renal dose adjustment is limited and it can be acceptable to continue pts of FTC past the CrCl cut off. These decisions should be made with share decision making
@RuchiSane@BWDionne@jeffpears0n@davidwkubiak https://t.co/H9hOEwgHl7
#OTILT is the DURAPOP trial compared 8 days of Abx tx to 15 days in critically ill pts and found that there was no clinical benefit for a 15 day treatment compared to 8 days.
@RuchiSane@BWDionne@jeffpears0n@davidwkubiak https://t.co/Lulpw040im
#OTILT is that Sulbactam has activity against Acinetobacter baumannii, even though it is a beta-lactamase inhibitor. It was approved w/ durlobactam for HAP/VAP caused by Acinetobacter baumannii
@RuchiSane@BWDionne@jeffpears0n@davidwkubiak https://t.co/sHMsI4006r
#OTILT is that linezolid has an increase risk for thrombocytopenia. This makes it an unideal choice for longer courses of tx such as infective endocarditis.
@RuchiSane@BWDionne@jeffpears0n@davidwkubiak https://t.co/x7gq7oEW5Q
#OTILT is that HIV mutations will be present when there is a need for the virus to produce that mutation in the presence of tx the mutation produces resistance for. Wild type is more "fit" without drug tx
@RuchiSane@BWDionne@jeffpears0n@davidwkubiak https://t.co/xBDeiqK9d0