Had a lot of fun writing this news & views for @NatImmunol paper by @RyanMHobson and @WassimElyaman - congrats on publishing this new “blueprint” of brain border immunity! https://t.co/pMMFhP4bSE
Excited to share that our paper is now live in Nature Immunology.
We identified highly expanded CD8+ T cell clones in the human leptomeninges and uncovered key changes in this immunological niche during neurodegeneration.
I am grateful to an incredible group of coauthors and collaborators, including @WassimElyaman, for their support on this project. @ColumbiaMed
https://t.co/iZL6098Yli
CHOIR is now online @NatureGenet! CHOIR is a new clustering method for single-cell data that evaluates whether clusters represent statistically distinct cell populations. CHOIR scales to millions of cells and works with single-/multi-omic data of any type!
https://t.co/EKg20yMygH
Out in @CellCellPress now with added data and analysis! @Huixin_BJ and colleagues report that the choroid plexus has specialized epithelial-immune synergy that modulates epithelial barrier plasticity during brain inflammation. https://t.co/sh8gHyKgOn
In a mouse model of #Alzheimer’s disease, amyloidosis itself triggers age-related #oligodendrocyte and #myelin damage mediated by CD8+ T cells that promote the accumulation of interferon-activated myelin-damaging #microglia
https://t.co/StqjJbezAX
Excited to share our group's first manuscript describing new anatomical connections that allow the eyes to act as an "immunological window to the brain" 👁️🧠 (1/)
https://t.co/mpIEqvZSE5
Reserve your spot for our upcoming webinar to hear how the Elyaman lab at Columbia University has delineated a first-in-human comprehensive view of the immunological landscape in the brain and its borders with the #MA900 Multi-Application Cell Sorter.
➣ https://t.co/KJOao5cYVn
@WassimElyaman@Columbia@WassimElyaman it was a great inaugural symposium. Inspiring talks from leaders in neuroimmunology and a welcoming environment to discuss science at the poster session over lunch. What more could you ask for?
A genome-wide in vivo #CRISPR screen identifies essential regulators of T cell migration to the CNS in a multiple sclerosis model
New from @kerlab@KawakamiLab@arekken@claradelarosa96 et al.
https://t.co/6i9DEyZM32