The Baker Lab has a new #openaccess paper in
@NatureComms showing that dramatic improvements can be achieved when deep learning software is used to design protein-binding proteins.
Full paper ➡️ https://t.co/Z1t0qImOKj
Short summary ⬇️
https://t.co/O4qKKLnN9r
Protein engineers are drawing on rapidly evolving machine learning tools, deep reservoirs of data, and the structure-predicting firepower of AlphaFold2 to pursue more sophisticated de novo protein designs https://t.co/ekecKTcRSe
SerenityBio completed the acquisition of DC-TAB, a HspB5 drug previously in the clinic for relapse-remitting multiple sclerosis. https://t.co/HANnowq5jT
We have gathered a deep knowledge of the therapeutic potential of this protein, and we believe it will be the best-in-class therapy for lupus nephritis. Part of our work was recently published in AutoImmunity.
And there's more to come.
3) This work led SerenityBio to discover a target on macrophages (and other immune cells) that can be 'hit' with a small molecule. This opens doors to an orally bioavailable therapeutic.
There’s more to come later this year.
How can immunologists build biotech products ranging from consumer products to therapeutics? Join IndieBio on April 20 to meet 3 founders whose startups rely on the principles of immunology.
#biotech#immunology@SBioworks@intrinsicmed @BeFreeToFeed
https://t.co/nymQXsLs0Y
In this @CellReports article:
💡 Human #myeloid cells show lineage-specific transcriptional responses to TLR activation.
💡 #Monocytes display an exaggerated pro-inflammatory profile in response to TLR8 ligand.
@CincyChildrens
Full article: https://t.co/Q9C6gI2xEl
New Research: Psychological Stress, Intestinal Barrier Dysfunctions, and Autoimmune Disorders: An Overview: Autoimmune disorders (ADs) are multifactorial diseases involving, genetic, epigenetic, and environmental factors characterized by an… https://t.co/jBRX1DjJmg #immunology