Single Cell Precision Inc

Single-cell transcriptomics, biomarker discovery, precision health.

email: [email protected]

[Dr. Paola Marignani @pmarignani]

Finding 1: LKB1 loss suppresses oestrogen, progesterone, and androgen receptor signalling.
LKB1 is not just a metabolic kinase, it actively supports hormone-responsive transcriptional programs. Losing it reshapes the hormone landscape of the tumour cell.

[Dr. Paola Marignani @pmarignani]

We combined:
🔬 CRISPR-Cas9 STK11 KO + scRNA-seq in ER+/HER2+ & TNBC cell lines
🧬 Patient tumour single-cell RNA-seq
📊 METABRIC bulk genomics (n=1,734)
🐭 Mammary-specific Lkb1^fl/fl^/WAP-Cre mouse model

[Single Cell Precision Inc @SCellPrecision]

@modernHealthMe Giardia. Beaver fever

[Single Cell Precision Inc @SCellPrecision]

Peutz-Jeghers Syndrome. LKB1 mutation

[Dr Honey choudhary 🩺 @Doctors__squad]

15-year-old female 👧
Dark pigmentation over lips & oral mucosa
12-year history of intermittent abdominal pain
Recent vomiting & weight loss

What is the diagnosis? 🤔

[Christian Fankhauser @FankhauserCh]

I have a PhD student and a post-doc position available in my lab to work on plant photobiology. Please use the links below to postulate
Please RT, many thanks
https://t.co/PNIXuCNRpf

https://t.co/MVoigOcDu4

[Dr. Paola Marignani @pmarignani]

Thanks @CEEHRC for the opportunity to share my research journey ! #ScienceIsFun https://t.co/nidSWvLyhr

[Dr. Paola Marignani @pmarignani]

Congratulations @ArunaRevolution! So very proud of you and your journey
@creativedlab https://t.co/nDG5rHaeQn

[Single Cell Precision Inc @SCellPrecision]

Please join us on #BlueSky
New group formed that is focused on all things #singlecell and #spatialtranscriptomics
Use this link to join. https://t.co/tZseZfZdwD

[Single Cell Precision Inc @SCellPrecision]

Sharing our computational pipeline with attendees at @CSHL Asia. @InvestNS_

[Andrew J. Roger (@andrewjroger.bsky.social) @andrewjroger]

@pmarignani @DalhousieU I know. It's insane how much open access can cost. I think PubMed Central is an option and would comply with open access requirements for CIHR and NSERC: https://t.co/dbWLr0kcUz

[Dr. Paola Marignani @pmarignani]

To all the girls who dream big...dream bigger, dream with conviction. @CDNWomenSTEM
@ayaLAN @TiffMakesWaves @dredwardsvr #WomenExplorers #GirlExplorers

#InternationalDayoftheGirl

[Walid Khaled @WTKLAB]

Come join the lab as a PhD starting October 2025

We have a project on "Therapeutic cancer prevention of hereditary cancers" 🧬+💊+🐁

funded by @AstraZeneca in collaboration Andrew Reynolds and Mark Albertella

Full details and eligibility: https://t.co/dmEtBtJy19

Please RT

[Dr. Paola Marignani @pmarignani]

As a Canada's Strategy for Patient-Oriented Research (SPOR) Refresh Engagement Roundtable participant, I am pleased to share the outcome of our efforts. @CIHR_IRSC #PatientEngagement #PatientAdvocacy

https://t.co/T5IDgDO8lr

[Dr. Paola Marignani @pmarignani]

Wonderful opportunity to #mentor the next generation of #WomenEntrepreneurs. Thanks @creativedlab @CDNWomenSTEM #EmpoweringYouth #CDLApprenticeProgram https://t.co/UdrfzQY0zZ

[Canadian Epigenetics @CEEHRC]

Only 3 more days to submit an abstract for talk consideration or if you want to apply for a travel award for the @CEEHRC Annual Meeting on Oct 1-4, 2024!

We've got an outstanding lineup of speakers again this year.

https://t.co/1fYtaFeoyf

#epigenetics #epigenomics

[Tony Kwan @DrTonyKwan]

Deadline is this Friday if you want your abstract to be considered for a talk. Don't miss out!

https://t.co/s5cTTXAYtd

[Dr. Paola Marignani @pmarignani]

Summer fun with #MarignaniLab members. Enjoying an early afternoon lunch, reminiscing about the school year and talking about future goals! #ScienceIsFun #researchmatters @DalhousieU @DalScience @DalMedSchool @DalInnovates @CDNWomenSTEM @WiSTEMDal

[Tony Kwan @DrTonyKwan]

Once again, there's a great lineup of speakers for this meeting. We're excited to see you in October!

[Dr. Paola Marignani @pmarignani]

Excited for @10xGenomics and @SCellPrecision presenting at @DalhousieU #scRNAseq and #Spatial #transcriptomics.

[Dr. Paola Marignani @pmarignani]

Looking forward 2 sharing #discoveries from #MarignaniLab with #Italian 🇮🇹Ambassador to 🇨🇦, Andrea Ferrari @ItalyinCanada & colleagues @mirco_ravanelli & Andrea Capra @TRIUMFLab
@DalhousieU @DalMedSchool @DalScience @DalInnovates #ItaloCanadese #scienzapertutti #lascienzasalva