SHU-HONG LIN

Senior Scientist, computational biology at BioNTech US. Molecular epidemiology, population genetics, and bioinformatics. Opinions are my personal view

[SHU-HONG LIN @SHUHONGLIN]

@mitchiela @NatureGenet @NCIEpiTraining Congrats, Mitch!

[SHU-HONG LIN @SHUHONGLIN]

@Rohit_thakurrr Microsoft is integrating the copilot functionality into the office suite. Hopefully it will be available soon. In the meantime, gamma already implemented GPT-assisted slide creation:
https://t.co/rAoir3Tsdo

[SHU-HONG LIN @SHUHONGLIN]

@hubermanlab 1. What is the biological bases for absolute pitch?
2. How do we explain the preferences for harmonious chords?
3. How does playing instruments change the brain?
4. Does listening to music help patients recover from stroke?

[Mitchell Machiela @mitchiela]

Our paper on LDexpress, an online tool for integrating population-specific linkage disequilibrium patterns with tissue-specific expression data, is online today:
https://t.co/qW2ZTFEeeh
The tool can be found here:
https://t.co/JuDHxoezrU
#NCI_ITEB @SHUHONGLIN @Rohit_thakurrr

[SHU-HONG LIN @SHUHONGLIN]

@NCIEpiTraining @mitchiela So lucky to have such wonderful mentor like Dr. @mitchiela !

[Mitchell Machiela @mitchiela]

Our PheWAS of mosaic chromosomal alterations in UK Biobank identifies a range of incident disease associations and highlights the critical importance of careful covariate adjustment in studies of clonal hematopoiesis
@SHUHONGLIN @NCIEpiTraining #NCI_ITEB
https://t.co/9OrgtZtHxg

[SHU-HONG LIN @SHUHONGLIN]

@DerekWBrown_1 Congrats!

[SHU-HONG LIN @SHUHONGLIN]

Our manuscript is published! Many thanks for my mentor @mitchiela, lab mate @DerekWBrown_1, and fantastic collaborators @zekavatm and @pnatarajanmd!

[Pradeep Natarajan @pnatarajanmd]

Our paper explores the X chromosome, the oft-neglected/excluded chr of GWAS, and describe a locus associated with favorable lipids, CAD risk, T2D risk, and adiposity distribution https://t.co/TArb7b8sa0 @NatureComms

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[Mitchell Machiela @mitchiela]

We examined blood samples at birth for clonal hematopoiesis (CH) associated with fetal Zidovudine exposure. Our results suggest CH at levels detectable in our study is not strongly influenced by in utero ZDV exposure.
@SHUHONGLIN @EricEngelsMD #NCI_ITEB
https://t.co/zRdHkYVdRN

[Mitchell Machiela @mitchiela]

We find evidence that detectable chromosome X mosaicism is rarely tolerated in males, illustrating the importance of the male X chromosome for peripheral leukocyte function.
#NCI_ITEB @NCIEpiTraining @WeiyinZ @SHUHONGLIN @NCIChanock

https://t.co/xZ02qQ2FCO

[SHU-HONG LIN @SHUHONGLIN]

A team effort among my coolest mentor @mitchiela and lab mate @DerekWBrown_1 at the NCI as well as excellent collaborators, especially @pnatarajanmd and @zekavatm at MGH!

[Pradeep Natarajan @pnatarajanmd]

Super excited to share our new preprint regarding clonal hematopoiesis and risk for infection, including COVID-19.
Lots of excitement re: vaccines. Can we use molecular profiling to help prioritize initial vaccine programs? Read below! @zekavatm @SHUHONGLIN @freeseek82 @mitchiela

[SHU-HONG LIN @SHUHONGLIN]

@elonmusk There are two major types of qPCR. SYBR green and TaqMan. SYBR Green has one pair of primer while TaqMan comes with an additional probe which dramatically increases specificity. If the lab you talked to use the TaqMan assay designed by WHO, there shouldn’t be false positivity.

[SHU-HONG LIN @SHUHONGLIN]

Our new module is online. Thanks to my mentor @mitchiela and excellent engineers at NCI! Please feel free to test it out and let us know if you have suggestions or requests.

[Mitchell Machiela @mitchiela]

LDexpress is live! Seamlessly integrate population-specific linkage disequilibrium data from @1000genomes and tissue-specific expression data from @GTExPortal to explore regional genetic variation impacting gene expression.
#LDlink @SHUHONGLIN @NCIDataSci
https://t.co/JuDHxowaQu

[Eric Topol @EricTopol]

Virus 49, US States 1
Vermont the only holdout
https://t.co/BuuW28dyJl

[SHU-HONG LIN @SHUHONGLIN]

Congratulations to my excellent colleagues!

[Derek W Brown @DerekWBrown_1]

Fantastic job!! Congratulations!

[Yale School of Public Health @YaleSPH]

Dr. Anthony Fauci lays out three ways future scientific communicators can build trust:

1) Always go by the data
2) Admit when you don't know something
3) The goal is not to show how smart you are. It's to get people to understand what you're talking about.

#FauciAtYale

[Mitchell Machiela @mitchiela]

Out today in @PLOSONE is our paper on low-frequency variants and #Ewing sarcoma risk. We find evidence suggesting common germline susceptibility loci may harbor additional independent associations with rare and low-frequency variants. #NCI_ITEB @SHUHONGLIN
https://t.co/MWYhbGu5SZ

[SHU-HONG LIN @SHUHONGLIN]

Our new tool has been published!

[Mitchell Machiela @mitchiela]

Online today in @CR_AACR is our paper on #LDtrait, a new #LDlink tool for identifying published phenotype associations in linkage disequilibrium

https://t.co/inUhvLDgSS

@SHUHONGLIN @DerekWBrown_1 #NCI_ITEB @NCIEpiTraining

[SHU-HONG LIN @SHUHONGLIN]

A very nice work by my dear friend and colleague, Derek!