Inhibiting macropinocytosis may offer a novel therapeutic avenue to combat pulmonary fibrosis by reducing profibrotic responses in lung cells.
by Rosas IO, McDowell-Sanchez AK (...) Tsoyi K et 11 al. in J Clin Invest
https://t.co/DPquy75KzQ #MedX#MedResearch
Targeting fatty acid oxidation linked to KRAS inhibition offers a promising therapeutic strategy to combat pancreatic cancer's metabolic vulnerabilities.
by Thakur R, Wang D (...) Singh PK et 19 al. in Cancer Res
https://t.co/HEG6T3USBM #MedX#MedResearch
Cumulative lead exposure drives significant cardiovascular mortality, contributing to 3.5 million deaths and 71.6 million DALYs globally in 2023.
by None None, Stanaway JD (...) Brauer M et 9 al. in JAMA
https://t.co/fh0NgT8hfG #MedX#MedResearch
Targeting TRIM28 offers new hope for reducing ferroptosis and preventing myocardial injury post-ischemia/reperfusion in heart disease patients.
by Zhu K, Guo J (...) Cao CM et 19 al. in Circulation
https://t.co/BMZnvD9RnP #MedX#MedResearch
Anti-nephrin autoantibodies rarely occur in podocytopathies, challenging their role as specific biomarkers in kidney diseases.
by Pecoraro F, Perico L (...) Remuzzi G et 11 al. in J Clin Invest
https://t.co/6dauughqJf #MedX#MedResearch
Iron overload in steatotic liver cells disrupts metabolism by altering hepatokine production, but targeted therapies show potential for reversal.
by Jo HJ, Kim A (...) Han CY et 24 al. in J Clin Invest
https://t.co/SQ0i1dWYey #MedX#MedResearch
Cardiac resynchronization therapy significantly reduces all-cause mortality and heart failure hospitalizations in patients with systolic dysfunction and dyssynchrony.
by Ternes CM, Kim JA (...) Chelu MG et 2 al. in JAMA
https://t.co/HyomF1ljww #MedX#MedResearch
Chronic pancreatitis demands a shift toward early intervention and patient-tailored therapies to modify disease progression and manage inflammation.
by Mahapatra SJ, Dhar Chowdhury S, Akshintala VS and Garg PK in Gastroenterology
https://t.co/jwMDdXGXem #MedX#MedResearch
Bardet-Biedl syndrome in children reveals high rates of obesity and short stature, but low prevalence of endocrine disorders.
by Varughese RS, Pujari D (...) Chesover AD et 12 al. in J Clin Endocrinol Metab
https://t.co/yCFT3ML7wB #MedX#MedResearch
New AMOCO Method Transforms Ungated Hepatic 4D Flow MRI, Enhancing Image Quality and Flow Measurement Consistency Without Extended Scan Times
by Cao R, Li S (...) Li H et 12 al. in Magn Reson Med
https://t.co/4nGnIevE0P #MedX#MedResearch
Dystonia severity links to brain volume changes and NAD levels, unveiling metabolic differences in GCH1 mutation carriers.
by Prasuhn J, van Well L (...) Brüggemann N et 10 al. in Mov Disord
https://t.co/jHpn3pG2v9 #MedX#MedResearch
Monoclonal antibody L9LS offers 42.7% malaria protection in young Kenyan children, demonstrating safety and potential for further efficacy enhancements.
by Steinhardt LC, Kwambai TK (...) Seder RA et 25 al. in Lancet
https://t.co/1Ga2xHypQP #MedX#MedResearch
Study reveals skipping defibrillation testing during subcutaneous ICD implantation, guided by the PRAETORIAN score, maintains shock efficacy while reducing risks.
by Knops RE, Marquie C (...) El-Chami MF et 44 al. in Circulation
https://t.co/XpF8nAjtws #MedX#MedResearch
Pediatric subspecialists' lifetime earnings gap against adults has widened from 15.7% in 2014 to 20.2% in 2024, threatening workforce sustainability.
by Gadiwala S, Shukla A (...) Daily J et 3 al. in Pediatrics
https://t.co/RxKalovoak #MedX#MedResearch
TREX1's unique dsDNA-binding architecture modulates cGAS-STING signaling, highlighting its role in autoimmune responses and potential cancer immunity.
by Zhu J, Wang L (...) Zhou W et 5 al. in Immunity
https://t.co/QWPV0QSHJy #MedX#MedResearch
Transdermal estradiol patches demonstrate noninferior metastasis-free survival compared to LHRH agonists, with fewer hot flashes but more gynecomastia.
by Langley RE, Gilbert DC (...) Nankivell M et 49 al. in N Engl J Med
https://t.co/3uh1KWYCNX #MedX#MedResearch
MplW514L mutation drives essential thrombocythemia and myelofibrosis in mice, revealing targeted therapy limitations against disease-initiating stem cells.
by Zhang S, Liu J (...) Zhao B et 9 al. in J Clin Invest
https://t.co/RmE4ry1wr1 #MedX#MedResearch
Ciliated cells in the fallopian tube are pivotal guardians against DNA damage, critical for preventing high-grade serous carcinoma initiation.
by Colina JA, Recouvreux MS (...) DiFeo A et 28 al. in Cancer Res
https://t.co/nA9gXYAge2 #MedX#MedResearch