STITCHES Medicine - the Best of Medical Research

From the experience of @stitchestoday, we bring you the best papers in medicine, daily!

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[STITCHES Medicine - the Best of Medical Research @STITCHESMed]

GPT-5 showed no clinical superiority over previous models, despite launch claims, highlighting ongoing risks to patient safety and privacy.

https://t.co/OIzOPPFNhq

@OpenAI @sama @miramurati @EricTopol @rohanpaul_ai @DeryaTR_ @deedydas @agingdoc1 @strnr @rmh199 @tmboussard

[STITCHES Medicine - the Best of Medical Research @STITCHESMed]

Inhibiting macropinocytosis may offer a novel therapeutic avenue to combat pulmonary fibrosis by reducing profibrotic responses in lung cells.

by Rosas IO, McDowell-Sanchez AK (...) Tsoyi K et 11 al. in J Clin Invest
https://t.co/DPquy75KzQ #MedX #MedResearch

[STITCHES Medicine - the Best of Medical Research @STITCHESMed]

Targeting fatty acid oxidation linked to KRAS inhibition offers a promising therapeutic strategy to combat pancreatic cancer's metabolic vulnerabilities.

by Thakur R, Wang D (...) Singh PK et 19 al. in Cancer Res
https://t.co/HEG6T3USBM #MedX #MedResearch

[STITCHES Medicine - the Best of Medical Research @STITCHESMed]

Cumulative lead exposure drives significant cardiovascular mortality, contributing to 3.5 million deaths and 71.6 million DALYs globally in 2023.

by None None, Stanaway JD (...) Brauer M et 9 al. in JAMA
https://t.co/fh0NgT8hfG #MedX #MedResearch

[STITCHES Medicine - the Best of Medical Research @STITCHESMed]

Targeting TRIM28 offers new hope for reducing ferroptosis and preventing myocardial injury post-ischemia/reperfusion in heart disease patients.

by Zhu K, Guo J (...) Cao CM et 19 al. in Circulation
https://t.co/BMZnvD9RnP #MedX #MedResearch

[STITCHES Medicine - the Best of Medical Research @STITCHESMed]

Anti-nephrin autoantibodies rarely occur in podocytopathies, challenging their role as specific biomarkers in kidney diseases.

by Pecoraro F, Perico L (...) Remuzzi G et 11 al. in J Clin Invest
https://t.co/6dauughqJf #MedX #MedResearch

[STITCHES Medicine - the Best of Medical Research @STITCHESMed]

Iron overload in steatotic liver cells disrupts metabolism by altering hepatokine production, but targeted therapies show potential for reversal.

by Jo HJ, Kim A (...) Han CY et 24 al. in J Clin Invest
https://t.co/SQ0i1dWYey #MedX #MedResearch

[STITCHES Medicine - the Best of Medical Research @STITCHESMed]

Cardiac resynchronization therapy significantly reduces all-cause mortality and heart failure hospitalizations in patients with systolic dysfunction and dyssynchrony.

by Ternes CM, Kim JA (...) Chelu MG et 2 al. in JAMA
https://t.co/HyomF1ljww #MedX #MedResearch

[STITCHES Medicine - the Best of Medical Research @STITCHESMed]

Chronic pancreatitis demands a shift toward early intervention and patient-tailored therapies to modify disease progression and manage inflammation.

by Mahapatra SJ, Dhar Chowdhury S, Akshintala VS and Garg PK in Gastroenterology
https://t.co/jwMDdXGXem #MedX #MedResearch

[STITCHES Medicine - the Best of Medical Research @STITCHESMed]

Bardet-Biedl syndrome in children reveals high rates of obesity and short stature, but low prevalence of endocrine disorders.

by Varughese RS, Pujari D (...) Chesover AD et 12 al. in J Clin Endocrinol Metab
https://t.co/yCFT3ML7wB #MedX #MedResearch

[STITCHES Medicine - the Best of Medical Research @STITCHESMed]

Families Face Steep Premium Hikes After ACA Enhanced Tax Credits Expire, Burdening Lower-Income Households Significantly.

by Goldstein Novick NP, Formanowski B (...) Salazar EG et 4 al. in Pediatrics
https://t.co/oyXEZW8cAb #MedX #MedResearch

[STITCHES Medicine - the Best of Medical Research @STITCHESMed]

New AMOCO Method Transforms Ungated Hepatic 4D Flow MRI, Enhancing Image Quality and Flow Measurement Consistency Without Extended Scan Times

by Cao R, Li S (...) Li H et 12 al. in Magn Reson Med
https://t.co/4nGnIevE0P #MedX #MedResearch

[STITCHES Medicine - the Best of Medical Research @STITCHESMed]

Dystonia severity links to brain volume changes and NAD levels, unveiling metabolic differences in GCH1 mutation carriers.

by Prasuhn J, van Well L (...) Brüggemann N et 10 al. in Mov Disord
https://t.co/jHpn3pG2v9 #MedX #MedResearch

[STITCHES Medicine - the Best of Medical Research @STITCHESMed]

Monoclonal antibody L9LS offers 42.7% malaria protection in young Kenyan children, demonstrating safety and potential for further efficacy enhancements.

by Steinhardt LC, Kwambai TK (...) Seder RA et 25 al. in Lancet
https://t.co/1Ga2xHypQP #MedX #MedResearch

[STITCHES Medicine - the Best of Medical Research @STITCHESMed]

Study reveals skipping defibrillation testing during subcutaneous ICD implantation, guided by the PRAETORIAN score, maintains shock efficacy while reducing risks.

by Knops RE, Marquie C (...) El-Chami MF et 44 al. in Circulation
https://t.co/XpF8nAjtws #MedX #MedResearch

[STITCHES Medicine - the Best of Medical Research @STITCHESMed]

Pediatric subspecialists' lifetime earnings gap against adults has widened from 15.7% in 2014 to 20.2% in 2024, threatening workforce sustainability.

by Gadiwala S, Shukla A (...) Daily J et 3 al. in Pediatrics
https://t.co/RxKalovoak #MedX #MedResearch

[STITCHES Medicine - the Best of Medical Research @STITCHESMed]

TREX1's unique dsDNA-binding architecture modulates cGAS-STING signaling, highlighting its role in autoimmune responses and potential cancer immunity.

by Zhu J, Wang L (...) Zhou W et 5 al. in Immunity
https://t.co/QWPV0QSHJy #MedX #MedResearch

[STITCHES Medicine - the Best of Medical Research @STITCHESMed]

Transdermal estradiol patches demonstrate noninferior metastasis-free survival compared to LHRH agonists, with fewer hot flashes but more gynecomastia.

by Langley RE, Gilbert DC (...) Nankivell M et 49 al. in N Engl J Med
https://t.co/3uh1KWYCNX #MedX #MedResearch

[STITCHES Medicine - the Best of Medical Research @STITCHESMed]

MplW514L mutation drives essential thrombocythemia and myelofibrosis in mice, revealing targeted therapy limitations against disease-initiating stem cells.

by Zhang S, Liu J (...) Zhao B et 9 al. in J Clin Invest
https://t.co/RmE4ry1wr1 #MedX #MedResearch

[STITCHES Medicine - the Best of Medical Research @STITCHESMed]

Ciliated cells in the fallopian tube are pivotal guardians against DNA damage, critical for preventing high-grade serous carcinoma initiation.

by Colina JA, Recouvreux MS (...) DiFeo A et 28 al. in Cancer Res
https://t.co/nA9gXYAge2 #MedX #MedResearch

[STITCHES Medicine - the Best of Medical Research @STITCHESMed]

Focal coronary artery disease significantly enhances symptom relief from PCI, outperforming diffuse disease in improving angina and exercise capacity.

by Chiew K, Foley MJ (...) Al-Lamee RK et 14 al. in J Am Coll Cardiol
https://t.co/6ZfRK71BWI #MedX #MedResearch