Adding consolidative thoracic radiotherapy to atezolizumab maintenance for extensive-stage small cell lung cancer led to more severe toxic effects, mainly infections, without survival benefit compared to atezolizumab alone.
https://t.co/hKB5mKLA6A
Phase 3 HARMONi-6 OS data are in: ivonescimab + chemo delivered a meaningful survival advantage over tislelizumab + chemo in previously untreated advanced squamous NSCLC, with a manageable safety profile. Shun Lu, MD, PhD reports the findings.
Watch the full OncLive® Rapid Readout: https://t.co/imSJM0SWDo
#NSCLC #LungCancer #Ivonescimab
Adjuvant therapy in colon cancer has come a long way. FOLFOX and capecitabine remain the backbone, but a series of trials highlight how we can go beyond “chemo as usual” to improve both tolerability and efficacy:
🧬 ALASCCA – In stage II–III CRC with PI3K pathway mutations, daily aspirin (160 mg) cut recurrence risk by ~50% (HR 0.49).
🖐 D-TORCH – Topical diclofenac gel reduced grade ≥2 hand-foot syndrome from 15% → 3.8% at 12 weeks, keeping more patients on full-dose capecitabine.
💊 B12 – Methylcobalamin supplementation lowered the rate of clinically significant HFS (BMJ 2025), a low-cost and safe toxicity-mitigation strategy.
🏃 CHALLENGE – Structured exercise after adjuvant therapy lowered recurrence/new primary risk by 28% and death by 37% over long-term follow-up.
These studies point to a bigger picture: adjuvant therapy isn’t just about getting through chemo. It’s about layering strategies that make treatment more tolerable while meaningfully boosting outcomes.
What else should we be adding to the adjuvant colon cancer playbook (no more bolus 5-FU)?
@TheGutOncLab@OncoAlert@OncBrothers
A Jail trial for Chairman Imran Khan is absolutely unconstitutional, illegal. A fair and open court trial must be held in this case, as the Nation deserves to know those who are behind the conspiracy against Pakistan!
#ImranKhanNeedsJustice
آہستہ آہستہ عمران ریاض خان کے حق میں آواز اُٹھانے والے کم ہو رہے ہیں، عمران ریاض خان نے ہر مظلوم کے حق میں زوردار آواز بلند کی ہے، کیا ہمارا فرض نہیں کہ ہم روزانہ چند ٹویٹ عمران ریاض بھاٸی کے حق میں کریں۔
#ReleaseImranRiazkhan
اگر آپ یہ ٹویٹ دیکھ رہیں ہیں تو ریٹویٹ کریں اور یہ ٹرینڈ
#ReleaseImranRiazKhan
جوائن کریں۔۔۔
عمران ریاض خان کے لئے آواز اٹھائے ور اس ٹرینڈ کو پاکستان پینل پر لائے
My business, the oldest steel trading & manufacturing company of Pakistan has been sealed again today in violation of court orders. The officials present said they do not care for any court order. Last time police said they did it for 'security reasons'. This time anti corruption unit thinks I colluded with some officials to bypass building regulations when it was constructed 26 years ago (I was in school at that time).
This represents another draconian and fascist tactic to pressurise me. So far I have been nominated in 8 anti terror cases for leading protests on 9th and 10th may (I was actually not present in any of them).
There have been six raids on my home. CCTVs broken and equipment stolen. My father, 82 years of age, threatened on one of them that his other children will be taken. He was himself detained by police in the middle of the night 2 weeks ago. There have also been raids on my sisters homes.