Ni en sus peores momentos dejé de ser fan de The Strokes. 25 años consecutivos desde que escuché Someday por primera vez. Hoy me siento orgulloso de serlo.
Jon Bernthal quit The Punisher once. Then Marvel asked him to write it.
During the original Born Again production in 2023, Bernthal walked off set because he didn't like how Frank Castle was being written. An actor with no credited screenwriting experience looked at a Marvel paycheck and said no.
Marvel retooled the entire show. Hired Dario Scardapane from the original Punisher series as showrunner. Bernthal came back. Then during filming he pitched them a standalone special. Marvel reviewed his writing samples and told him to formally pitch it.
He co-wrote the screenplay with Reinaldo Marcus Green, who directed King Richard. It runs 60 minutes, the longest Marvel Special Presentation ever. It carries a TV-MA rating. He's also an executive producer. First credited writing work of his career.
The line he gave in interviews: "I didn't want them to just hand it to me. They've held me accountable to every step along the way."
That's three MCU projects in one year. Born Again. One Last Kill. Spider-Man: Brand New Day. He filmed the Punisher special and then walked directly onto the Spider-Man set and told Tom Holland and the director the character had to feel the same across both.
The actor who had zero leverage in 2019 when Netflix canceled him now has more creative control over a Marvel character than almost any actor in the MCU's history. He got it by being willing to lose the role twice.
A massive Nature study of 27,885 GLP-1 users just dropped some major news about Ozempic and tirzepatide.
Your DNA determines how much weight you lose and how bad the side effects hit.
1 in 3 people see minimal results, and now we know why: (1/9)
@laORBITAdeENDOR Ha sido sacar el especial y este anuncio? Había información privilegiada … o mas bien secretitos… @zaphariel@lavozdehorus seguro que estan las destacadas
Rick Astley & the Foo Fighters perform "Never Gonna Give You Up" in the style of "Smells Like Teen Spirit", after Dave Grohl spotted Rick on the side of the stage and just pulled him up to do the song
Awiwi, perdón, Awiqli!!!
La insulina icodec logra su duración de una semana (acción ultra-larga) mediante modificaciones moleculares específicas que permiten una liberación lenta y sostenida en el torrente sanguíneo, a diferencia de las insulinas diarias convencionales
Mecanismos clave de la insulina icodec:
Estructura Molecular: La icodec es un análogo de insulina basal que se une a la albúmina (una proteína en la sangre) de manera fuerte pero reversible.
Lenta absorción: Al inyectarse subcutáneamente, la molécula se agrupa y forma multihexámeros que se descomponen lentamente, lo que resulta en una liberación continua y estable durante toda la semana.
Vida media prolongada: Gracias a su unión con la albúmina, la insulina icodec se degrada mucho más lentamente, manteniendo niveles constantes en sangre sin picos pronunciados durante aproximadamente 7 días.
Dosificación y Efecto: Permite controlar los niveles de glucosa durante toda la semana con una sola inyección, siendo una opción aprobada por la FDA para adultos
12 patients with metastatic cancer. Melanoma, breast, kidney.
Doctors injected a re-engineered antibody (CD40 agonist) into a single tumor. Not IV. Not systemic. One local shot.
The result: tumors shrank across the entire body, including at sites that were never touched.
2 of 12 patients hit complete remission. The injected tumors didn’t just shrink. They were replaced by organized immune tissue, tertiary lymphoid structures, essentially training camps for cancer-killing T cells.
Zero severe side effects.
The concept: instead of flooding the body with immunotherapy and hoping it finds the cancer, turn one tumor into a vaccine against itself. Train the immune system locally. Let it hunt globally.
Nearly 200 patients now in expanded trials across bladder, prostate, and brain cancers.
Published in @Cancer_Cell by Jeffrey Ravetch’s lab at @RockefellerUniv and @MSKCancerCenter
If you're like me and were not satisfied with the final version of the OBI-WAN KENOBI tv show, I can't recommend The Patterson Cut enough.
It's a fan edit that cut the series into a 2.5 hour movie, while also inserting new original scenes, VFX shots, and an opening crawl.
https://t.co/FI7YX23Ypa
Lucasfilm has just announced a new Star Wars story that stars Cassian Andor and takes place between the events of ANDOR Season 2 and ROGUE ONE 😳
Learn more here: https://t.co/uSILeucf9e
If you're like me and were not satisfied with the final version of the OBI-WAN KENOBI tv show, I can't recommend The Patterson Cut enough.
It's a fan edit that cut the series into a 2.5 hour movie, while also inserting new original scenes, VFX shots, and an opening crawl.
https://t.co/FI7YX23Ypa