Dr Sam Rowe

Investigator in GSK’s Chemical Biology Team UK with expertise in covalent drug discovery and Direct-to-Biology workflows. Views my own.

[Dr Sam Rowe @SamMRowe]

Congratulations to @HarryWilders and the team for getting this exciting ‘Direct-to-Biology’ work out there!

We generate cysteine-targeting chloroactemide reactive fragments and screen them without purification to optimise inhibitors of SARS MPro.

https://t.co/p9HAkxKHiJ

[Dr Sam Rowe @SamMRowe]

A pleasure to act as @JessCrompton’s Industrial Supervisor over the past year or so. She is an incredibly hard-worker and it’s wonderful to see that work rewarded with this nice publication in @JOC_OL 😊 If you need cyclopropyl acids, look no further! https://t.co/EHucdo8FlA

[Burley Research Group @BurleyResearch]

Our latest paper in collaboration with @GSK describes how the reactivity of a series of SuFEx reagents influences covalent modificaiton of the proteome. Congratulations to @KateGilbert_ , @Jake_T_Bush and @arronaatkar .
https://t.co/R1aoL66Yy4

[Dr Sam Rowe @SamMRowe]

Just posted a photo @ Wien, Österreich https://t.co/5ddQwdwHEP

[Dr Sam Rowe @SamMRowe]

@Cochrane_lab Agree! It’s so cool 😎

[Dr Sam Rowe @SamMRowe]

@KateGilbert_ Huge congrats, Kate 🥳

[Scott Lovell @scottlovell34]

I'm searching for a PhD student to start in my brand new lab @UniofBath in Oct 2022. The project will use phage display for covalent ligand discovery. Retweets are much appreciated. https://t.co/MYLrash30j

[Dr Sam Rowe @SamMRowe]

Great to see this nice piece of work out there!

Understanding the mechanisms of bacterial drug transport is going to be crucial in the coming years for overcoming the growing #antimicrobialresistance crisis.

https://t.co/C1ZuRFqspx

[Keith Hornberger @KRHornberger]

Time for another pharmacology tweetorial, this time on the distinction between IC50 and Ki. 1/

[Dr Sam Rowe @SamMRowe]

Graduation ✅

[Dr Sam Rowe @SamMRowe]

Nice to be at my first in-person conference in over 2 years! Hearing great talks about peptide chemistry. Looking forward to applying some of these strategies to my own work #BiologicsUK

[Oded Rechavi @OdedRechavi]

Reviewer looking for the figures at the end of the manuscript

[Dr Sam Rowe @SamMRowe]

@DPSynthChemist 😂😂

[Jacob Bush @Jake_T_Bush]

Congratulations to Ross Thomas and the team for this great work published in @ChemicalScience on accelerating PhABit design-make-test cycles using high-throughput chemistry. 🐇💫 #chembio #reactivefragments #covalentmodifiers https://t.co/OKjdrzEYLt

[Andryj Borys @AndryjBorys]

Nickel complex dying in 3...2...1... #RealTimeChem

[Chem Soc Rev @ChemSocRev]

Have you seen 'The multifaceted nature of antimicrobial peptides: current synthetic chemistry approaches and future directions' by David Spring & first author, Bee Ha Gan? @SpringGroupChem @ChemCambridge

Don't miss it #OpenAccess👇🔓https://t.co/fWnRc8B6IP

[Dr Sam Rowe @SamMRowe]

@NicolaAshman6 Congrats!

[Dr Sam Rowe @SamMRowe]

2nd dose done! Feeling very grateful and proud to be a scientist (not that I have anything to do with vaccines…)

[Dr Sam Rowe @SamMRowe]

Really nice paper showing synthesis of enantioenriched amides through N-alkylation rather than N-acylation using a dual copper catalytic cycle.

https://t.co/VSoMhW0WNR