Congratulations to @HarryWilders and the team for getting this exciting ‘Direct-to-Biology’ work out there!
We generate cysteine-targeting chloroactemide reactive fragments and screen them without purification to optimise inhibitors of SARS MPro.
https://t.co/p9HAkxKHiJ
A pleasure to act as @JessCrompton’s Industrial Supervisor over the past year or so. She is an incredibly hard-worker and it’s wonderful to see that work rewarded with this nice publication in @JOC_OL 😊 If you need cyclopropyl acids, look no further! https://t.co/EHucdo8FlA
Our latest paper in collaboration with @GSK describes how the reactivity of a series of SuFEx reagents influences covalent modificaiton of the proteome. Congratulations to @KateGilbert_ , @Jake_T_Bush and @arronaatkar .
https://t.co/R1aoL66Yy4
I'm searching for a PhD student to start in my brand new lab @UniofBath in Oct 2022. The project will use phage display for covalent ligand discovery. Retweets are much appreciated. https://t.co/MYLrash30j
Great to see this nice piece of work out there!
Understanding the mechanisms of bacterial drug transport is going to be crucial in the coming years for overcoming the growing #antimicrobialresistance crisis.
https://t.co/C1ZuRFqspx
Nice to be at my first in-person conference in over 2 years! Hearing great talks about peptide chemistry. Looking forward to applying some of these strategies to my own work #BiologicsUK
Congratulations to Ross Thomas and the team for this great work published in @ChemicalScience on accelerating PhABit design-make-test cycles using high-throughput chemistry. 🐇💫 #chembio#reactivefragments#covalentmodifiers https://t.co/OKjdrzEYLt
Have you seen 'The multifaceted nature of antimicrobial peptides: current synthetic chemistry approaches and future directions' by David Spring & first author, Bee Ha Gan? @SpringGroupChem@ChemCambridge
Don't miss it #OpenAccess👇🔓https://t.co/fWnRc8B6IP
Really nice paper showing synthesis of enantioenriched amides through N-alkylation rather than N-acylation using a dual copper catalytic cycle.
https://t.co/VSoMhW0WNR