Congratulations to @MHartleyLab for her grant awarded by the American Thyroid Association! You can view her acceptance video to learn more below!
https://t.co/oMNcERWjbX
Happy to announce new work published in @JMedChem ! The strategy should be useful for drug discovery efforts...
#CNS#drugdiscovery
A CNS-Targeting Prodrug Strategy for Nuclear Receptor Modulators https://t.co/xwzi4dGLFP
Autobahn is developing small molecule, thyroid hormone receptor beta agonists designed to stimulate remyelination and address the progressive nature of #MS and other diseases that result from demyelination. https://t.co/fuLMcn5G9I
Great work @MHartleyLab and the entire research team. We are getting very close to testing the FAAH targeted prodrug strategy in clinical trials for X-ALD and MS.
A little delayed, but I’m excited to share this research from a great team- Mitra, Maggie, Tania, @LisaKirkemo, and the fearless @ScanlanLab.
My first ever article in a NCS-family journal - a full year after I accepted a faculty position. 🤷♀️
highlights below...
Hartley et al. @ScanlanLab report that sobetirome, a selective agonist for thyroid hormone receptors, and its CNS-penetrating prodrug Sob-AM2 correct the lipid metabolism defect in X-linked adrenoleukodystrophy (X-ALD). https://t.co/Bz68jb5LcZ
Portlandia, here we come! Can’t wait to get to the @OHSUSOM Chemical Biology and Physiology meeting. First time bringing this kid on a work trip - thanks to @MichaelNADbio and all of the organizers for running a family friendly meeting!
Thank you @MHartleyLab for your outstanding work and leadership at @OHSUSOM and the Dept of CPB. You set a great example for us all and you will be missed.
Friday was my last day as a postdoc @OHSUSOM. Amazing views for my last day from @PortlandTram. Many thanks to the enthusiastic and supportive CBP department for everything over the years! @ScanlanLab @MichaelNADbio @XiangshuX@BingbingXLi
Check out Sky Ferrara’s poster @ScanlanLab tonight in the MEDI section and tomorrow at Sci-Mix #ACSSanDiego! He is presenting his awesome work on CNS-penetrating prodrugs of nuclear receptor modulators.
@kevansf@UCSF@kryamamoto Thanks for the heads up @kevansf. @kryamamoto was such an important mentor to me as a young faculty member @UCSF. So much awesome science and so many great conversations. All the best in whatever’s next Keith!
Congrats for a great team effort showcasing the therapeutic potential of brain penetrating thyroid hormone agonists. #OHSUResearch @MHartleyLab https://t.co/3D0SappFz6