Jonathan Schertzer (SchertzerLab)

Immunometabolism research: Diet, microbes, drugs and hormones

[Jens Lund @jens_lund]

Did the lactate metabolite family just get MUCH bigger?

Lactate has been studied for more than a century. But only in recent years have we begun exploring the metabolites that can be “spun off” from lactate.

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[Jonathan Schertzer (SchertzerLab) @SchertzerLab]

GDF15 suppresses liver inflammation independently of weight loss through neuroendocrine glucocorticoid signaling https://t.co/MWdFfoMVVG

[Jonathan Schertzer (SchertzerLab) @SchertzerLab]

Competitive catabolism drives hyperglycemia and hyperinsulinemia in obesity. https://t.co/I8qobIDGt3

[Jonathan Schertzer (SchertzerLab) @SchertzerLab]

Statins promote muscle metabolic danger and NLRP3-mediated myopathy via lower protein-prenylation and YAP https://t.co/L81aeGz8vN

[Jonathan Schertzer (SchertzerLab) @SchertzerLab]

Xenophagocytosis blockade enhances interspecies chimerism https://t.co/wljXCfvlWK

[Jonathan Schertzer (SchertzerLab) @SchertzerLab]

Advancing precision health discovery in a genetically diverse health system https://t.co/fWWhIS91fc

[Jonathan Schertzer (SchertzerLab) @SchertzerLab]

Distinctive DNA sequence features define epigenetic longevity of inflammatory memory https://t.co/L9LFSnfW39

[AJP-Endocrinology and Metabolism @AJPEndoMetab]

Take a short break to review today's Mini-Review #ArticleinPress, Immunometabolism of IRF4 in Adipose, #Muscle, and Immune Cells Influences #Obesity and MASLD (Daniel Marko and Jonathan Schertzer @McMasterU):

https://t.co/hXLX6JPCGS

[Jonathan Schertzer (SchertzerLab) @SchertzerLab]

Genomic atlas of Bifidobacterium infantis and B. longum informs infant probiotic design https://t.co/ssSrIxHp2O

[Jonathan Schertzer (SchertzerLab) @SchertzerLab]

Selective targeting of endothelial and perivascular angiocrine ROCK2 treats liver fibrosis https://t.co/Fny0kI6idj

[Jonathan Schertzer (SchertzerLab) @SchertzerLab]

Lactate production by tumor-resident Staphylococcus promotes metastatic colonization in lung adenocarcinoma https://t.co/EBKyOhpx6R

[Nature Metabolism @NatMetabolism]

TRIPping anti-tumour immunity through lactylation https://t.co/NM1iqTraLs

[Jonathan Schertzer (SchertzerLab) @SchertzerLab]

Preprint: CRY-NLRP3 complexes define a circadian checkpoint controlling inflammasome activation https://t.co/Z1kkeBQkTE

[Jonathan Schertzer (SchertzerLab) @SchertzerLab]

Targeting microbiota-generated acetaldehyde to prevent progression of metabolic dysfunction-associated steatotic liver disease https://t.co/ykDK42Wtx8

[Cell Reports @CellReports]

Insulin and adipocyte IRF4 promote fat retention over muscle preservation during intermittent fasting in obesity https://t.co/BcoWFBHf6m

[Jonathan Schertzer (SchertzerLab) @SchertzerLab]

Insulin and adipocyte IRF4 promote fat retention over muscle preservation during intermittent fasting in obesity https://t.co/4sKxUysAiy

[Cell Metabolism @Cell_Metabolism]

New! Online now: Lack of PCK1 in hepatic stellate cells causes liver fibrosis by fueling tricarboxylic acid cycle and increasing glycolysis https://t.co/Wm3XJB4xnV

[Jonathan Schertzer (SchertzerLab) @SchertzerLab]

Hepatic adaptation to chronic metabolic stress primes tumorigenesis: Cell https://t.co/Xa1qafGlnC

[Daniel J Drucker @DanielJDrucker]

In humans nighttime metabolic dysfunction is a hallmark of #MASLD with multiple pathogenic pathways upregulated at night, including hepatic and peripheral insulin resistance, DNL, and systemic NEFA exposure https://t.co/sAm5bRLsBR #circadian

[Kevin Hall @KevinH_PhD]

It was a great pleasure to meet @richroll and discuss nutrition and metabolism science on the @RichRollPodcast!