Seegar Lab

University of Cincinnati, College of Medicine
Studying membrane tethered proteases

[Seegar Lab @SeegarLab]

Structural basis for ADAM17 activation by the iRhom1 pseudoprotease: Cell Reports https://t.co/FAsgd8ZxsO

[Seegar Lab @SeegarLab]

Congratulations to all involved! Structural insights into the activation and inhibition of the ADAM17–iRhom2 complex | PNAS https://t.co/MayLWh1KfR

[Seegar Lab @SeegarLab]

Congratulations to folks that made this work come together.
https://t.co/YglqtNTKWG

[Seegar Lab @SeegarLab]

@WRgordonlab @BlacklowLab Well deserved- congratulations

[Cell Chemical Biology @CellChemBiol]

Online now! Heterogeneity of tethered agonist signaling in adhesion G protein-coupled receptors by Andrew N. Dates, Stephen C. Blacklow, and colleagues at @harvardmed @HMS_BCMP @DanaFarber https://t.co/1A352KLrVH #chembiol

[Xiaowei Hou @hou_xiaowei]

Calling incoming PhDs! We're searching for a postdoctoral fellow passionate about uncovering mechanistic mysteries related to human disease at the molecular level. #ResearchOpportunity #ScienceJobs Apply now:
https://t.co/p2291OIWL8

[Xiaowei Hou @hou_xiaowei]

🔬 Join our growing lab! We're searching for a postdoctoral fellow passionate about uncovering mechanistic mysteries related to human disease at the molecular level. #ResearchOpportunity #ScienceJobs Apply now: https://t.co/zYoSdSTC32

[Nicolas N. Nassar @NicolasNassar3]

Please RT (or RX?).
My lab is looking for a postdoctoral fellow with expertise in cryo-EM to solve the structure of the RAC activator VAV3 in complex with binding proteins.
Please email me if interested.

[BlacklowLab @BlacklowLab]

Congrats to Alex on his Notch paper published in Science Signaling! Special thanks to our fantastic team - Emily, Lena, Drew, Julia and collaborators. Click here to read the paper. https://t.co/9vEIE9Li9e

[BlacklowLab @BlacklowLab]

Congrats to Colin with a special thanks to Emily and Khal!

[Structural Biology @ActaCrystD]

Randy J. Read et al.: AlphaFold and the future of structural biology @Cambridge_Uni @AucklandUni @uwanews @UniofOxford @ActaCrystD @IUCr #AlphaFold #ProteinStructurePrediction #Crystallography https://t.co/EBFTQl2JQZ

[Harvard Med BCMP @HMS_BCMP]

Congratulations to @HMS_BCMP faculty member Karen Adelmen for her election to the American Academy of Arts and Sciences!  @AdelmanLab @harvardmed

[David Sprinzak @DavidSprinzak]

Our paper is out @ScienceAdvances! Check out how a single line of inner hair cells within the mammalian cochlea🐚 forms. Congrats to the fantastic @roecon91 @ShaharTaiber & Olga Loza. See the thread below. https://t.co/DvADHGvYCi

[Tom Thompson Lab @ThompsonLab3]

We have a Research Assistant position open in the Thompson Lab! We are looking for hard working individuals who are not afraid to learn new and diverse research techniques. Please see application links below. Fellow scientists please RT to spread the word!

[MurphyLab @MurphyLabUCONN]

Thanks to the folks @uofcincy for hosting a fun visit. Great to talk RNA regulation with @SeegarLab @catmak23 @igal_ifergan @TheLuolab @vestkat @IkegamiLab and others in the @biologyUC and @CincyChildrens - infectious enthusiasm in the grad students and faculty!

[Xiaowei Hou @hou_xiaowei]

AlphaFold predictions: great hypotheses but no match for experiment https://t.co/6w854rmhWr

[cryoEM Papers @cryoEM_Papers]

Structural Basis for Selective Proteolysis of ADAM10 Substrates at Membrane-Proximal Sites https://t.co/52tuJuNSNk

[Xiaowei Hou @hou_xiaowei]

Our department is hiring! We have a collegial and supportive environment for junior faculty here. Please feel free to DM me if you have any questions!

Assistant/Associate Professor, Structural Biology & Cryo-EM, Department of Molecular Genetics https://t.co/BKvt4wprpL

[The Nobel Prize @NobelPrize]

BREAKING NEWS:
The Royal Swedish Academy of Sciences has decided to award the 2022 #NobelPrize in Chemistry to Carolyn R. Bertozzi, Morten Meldal and K. Barry Sharpless “for the development of click chemistry and bioorthogonal chemistry.”

[Tom Thompson Lab @ThompsonLab3]

Congratulations to the @KovallRhett Lab and first author, Dr. Ellie Gagliani for their recent publication on understanding the mechanisms that drive Notch target gene dysregulation. https://t.co/zKvLINdp3a