Shalek Lab

Alex K. Shalek Lab @MIT/@ragoninstitute/@broadinstitute/@harvardmed/@MGH_RI. Genomics, immunology, systems biology.

[Adam Rubin @adamjrubin]

Excited to share our paper out today in @ScienceMagazine! We directed high-content, single-cell genetic screens to ask how a disordered adapter protein orchestrates the complex process of T cell activation. (1/4)

https://t.co/63pYd3UalF

[Shalek Lab @shaleklab]

Excited to be part of this @NatureNews feature on AI-powered drug discovery, showing how gene-expression data can guide smarter, faster compound screening. @heidiledford @JimCollinsLab @ScienceMagazine @CellarityBio ! https://t.co/S0CR6WQoEE

[Shalek Lab @shaleklab]

We had a blast at the first All @MIT_IMES Retreat at the @ICAinBOSTON !

[MIT IMES @MIT_IMES]

.@MIT_IMES is accepting applicants for junior tenure-track faculty positions in all areas of #Science + #Engineering relating to health sciences to begin 7/1/2026. @MITEngineering @MIT More here: https://t.co/yt17CJE78S

[Shalek Lab @shaleklab]

Thanks for the write up @AlorSahoo + Karie Shen @thetech !

https://t.co/aWK8Sksxit

[Shalek Lab @shaleklab]

Thanks for the write up, @ChemistryMIT ! @ZhuBokai https://t.co/7iLCsxIfD9

[Shalek Lab @shaleklab]

Last week, Alex attended the CTVD Annual Conference in Cape Town, South Africa. The conversations, company, and views were enlightening! Here’s what going for a run with Al Leslie, Tom Scriba and Tom Hawn looked like.

[Shalek Lab @shaleklab]

A big week of celebrations! Congratulations to the lab members that defended this year: Constantine, Ivy, Sarah, and Josh (not pictured)! And also a farewell to Son ! Can't wait to see what's ahead for all of you!

[Bokai Zhu @ZhuBokai]

Check out our recent tool using deep learning to better discover immune cells in tissues! Always a pleasure to work with this great team: @ZongmingMa, @SizunJ, @GarryPNolan, @ironmathmo (Sheng Gao), @ShuxiaoC, @shaleklab and the rest who may or may not be on this platform!

[Ragon Institute @ragoninstitute]

We're proud to share highlights from the Immuno-Zambia 2.0 course held in Lusaka this October and led by Ragon Institute faculty member Zaza Ndhlovu, bringing together postgraduate students and post-doctoral fellows from across the continent and beyond.

#RagonInstitute #Africa

[Shalek Lab @shaleklab]

This work is a huge collaborative effort led by co-first authors @IvyNuoLiu, @kattan_walaa, Ben Mead, @cskummerlowe, co-supervised by @peterswinter, @SriRaghavanMD, @shaleklab, with contributions from our colleagues at CDoT @broadinstitute, @ragoninstitute & @MSFTResearch! (10/n)

[Shalek Lab @shaleklab]

🚀 Excited to share our new publication in @NatureBiotech! We explore scalable strategies for phenotypic screening using innovative methods with to address the challenges when the number of candidates is simply too large. Check out the details https://t.co/C0oan6L18a! (1/10)

[Shalek Lab @shaleklab]

🎯 In sum, our study charts a generalizable path to scalable phenotypic screening, overcoming limits with sample availability and costs. We hope this method speeds up the discovery of new treatments and target! Read the full paper: [link to paper] (9/10)