Peter Winter

Senior Group Leader at the Broad Institute of MIT and Harvard, co-leader of Broad // Microsoft Project Ex Vivo

[Sebastiano Cultrera di Montesano @sebacultrera]

Excited to share our latest preprint, introducing the hierarchical cross-entropy (HCE) loss — a simple change that consistently improves performance in atlas-scale cell type annotation models. https://t.co/uX6paEG8k6

[Alan DenAdel @AlanDenadel]

Current methods in the field are trained on atlases ranging from 1 to 100 million cells. In our newest preprint, we show that these same approaches tend to plateau in performance with pre-training datasets that are only a fraction of the size.

[Shalek Lab @shaleklab]

This work is a huge collaborative effort led by co-first authors @IvyNuoLiu, @kattan_walaa, Ben Mead, @cskummerlowe, co-supervised by @peterswinter, @SriRaghavanMD, @shaleklab, with contributions from our colleagues at CDoT @broadinstitute, @ragoninstitute & @MSFTResearch! (10/n)

[Peter Winter @peterswinter]

This one has been a long time coming! Very excited to get this highly collaborative work out. More evidence that considering cell states in conjunction with driver oncogenes needs a close look!

[Shalek Lab @shaleklab]

Excited to share our lab’s latest preprint exploring how mutations and transcriptional cell states cooperate to drive therapeutic resistance in Ph+ B cell acute lymphoblastic leukemia (Ph+ ALL)! (1/14) https://t.co/LDIA83nleg

[Shalek Lab @shaleklab]

Excited to share our lab’s latest preprint exploring how mutations and transcriptional cell states cooperate to drive therapeutic resistance in Ph+ B cell acute lymphoblastic leukemia (Ph+ ALL)! (1/14) https://t.co/LDIA83nleg

[𝗕𝗿𝗲𝗮𝗸 𝙏𝙝𝙧𝙤𝙪𝙜𝙝 𝗖𝗮𝗻𝗰𝗲𝗿 @break_cancer]

Happening now 9AM- 12:30PM! “Dissecting acquired resistance to KRASG12D inhibition in a mouse model of pancreatic ductal adenocarcinoma” #AACR2024 authored by our TeamLab members @Julien__Dilly, @shaleklab, S. Chugh,S. Dougan, B. Wolpin, @jonathan_nowak, @peterswinter, A. Aguirre

[Chibuikem Nwizu @ChibuikemNwizu]

1/5🚨 New preprint alert! Excited to share

NCLUSION: a Bayesian nonparametric framework using a sparse hierarchical Dirichlet process mixture model to jointly cluster and select marker genes!

📄https://t.co/mUOkvwTJbW
💻https://t.co/pKScTHLlSa
🌐 https://t.co/pbDS5FsNHs

🧵👇

[Cell @CellCellPress]

Don’t miss the @CellCellPress research of #FacesOfCell Andrew Navia, “Microenvironment drives cell state, plasticity, and drug response in pancreatic cancer” https://t.co/dFmUI3wkvy

[Britt Goods, Assistant Professor Dartmouth College @GoodsBrittany]

1/ Our paper that looks at cells in human breast over the course of lactation was published in PNAS this week! A press release from MIT covers this, but read on for more details!
Paper: https://t.co/qm37wXXimh
MIT News: https://t.co/YsHLORWzVg

[Sarah Nyquist @snyquist2]

So excited that our longitudinal study of the cells in human breast milk is out this week!

[Alex Jaeger @ajaeger40]

I am thrilled to officially announce that The Jaeger Lab is open for business at Moffitt Cancer Center in Tampa, FL! @MoffittResearch @MoffittNews

Excited for this next chapter, and ready for the opportunities and challenges ahead. Come join our team!

[email protected]

[Moffitt Research @MoffittResearch]

We want to send a warm welcome to Dr. Alex Jaeger. The newest faculty member of @MoffittNews Department of Molecular Oncology. https://t.co/gbEPIRUnkv

[Anirban Maitra @Aiims1742]

.@valarlabs is a new startup out of @Stanford on the application of #AI to #pathology (with an early focus on treatment decisions in #PancreaticCancer).
Eric Collisson from @UCSFCancer has a great quote in this story:
https://t.co/DCjSmLy8lv

[Peter Winter @peterswinter]

@lorin_crawford Couldn’t have happened to a nicer Lakers fan. Congrats Lorin!

[Lorin Crawford @lorin_crawford]

I guess I can comment on this now that it’s out in the public. Tenure… Wow. They say it takes a village and it’s so true. I’m just incredibly thankful for my community. No way this happens without them.

Looking forward to this next season 🙏🏾

[Shalek Lab @shaleklab]

1/10 Our new paper is out today in @natBME! Read the details here!https://t.co/13lPxPucLI

[Cancer Discovery @CD_AACR]

Read this week's Cancer Discovery #ResearchWatch Tumor Microenvironment Influences Cancer Cell Transcriptional State. https://t.co/MgZsPKThMt
@shaleklab @peterswinter @MIT @broadinstitute @harvardmed

[Stuart Schreiber @SchreiberStuart]

Congratulations to Carly Zeigler, a physician–scientist in training who gave a brilliant and inspiring lecture after receiving the inaugural 2021 Stuart L. Schreiber Award in Scientific Excellence for Graduate Students!

[Luca Pompella @LucaPompella]

Outstanding story just published in Cell @CellCellPress from Aguirre lab @DanaFarber_Hale and Shalek lab @shaleklab about microenvironmental modulation of pancreatic cancer cell states at single cell level. A must read! https://t.co/T5RX34Xwyp

[Anirban Maitra @Aiims1742]

Now online @CellCellPress
Microenvironment drives cell state, plasticity, and drug response in #PancreaticCancer
https://t.co/ze8tVVJ8cZ
Fantastic paper from Srivatsan Raghavan @shaleklab @andrewaguirremd @DanaFarber_Hale