Bram31

Somewhere between the intersection of antibiotics and infectious disease || ID scientist🦠🥼🧫 || Opinions and comments are my own

[Alí Sebastian Meza @AliSMV7]

Helicobacter pylori Eradication in the Era of Antibiotic Resistance: From Universal Regimens to Precision-Guided Management

https://t.co/xLUMQKVT2z

[Nature Reviews Microbiology @NatureRevMicro]

New online! Bacterial vesicles protect the membrane during polymyxin stress https://t.co/PgIRv8QYAO

[Kohei Hasegawa @kbot13533737]

緑膿菌活性がない抗菌薬でも低濃度持続曝露によりin vitroで緑膿菌の耐性化を引き起こす - Journal of Antimicrobial Chemotherapy(2026)

同系統で最もMIC上昇が顕著
ETP→MEM
CRO→CAZ
MFX→CIP

※CROやMFX曝露でMEM-MIC上昇もあり
※genotypeとphenotypeの因果は未証明

https://t.co/v0rcHnUXnv

[Nature Reviews Microbiology @NatureRevMicro]

New online! Klebsiella genus as driver of human disease: from infections to non-communicable disorders https://t.co/cGyWoXLZbS

[Nature Reviews Microbiology @NatureRevMicro]

New online! Fermented food microbiome: influence on oral and gut microbiota, and human health https://t.co/CvVqyUAwMS

[IDSA @IDSAInfo]

C. auris is a frequently multidrug-resistant emerging fungal pathogen able to persist and spread within healthcare environments.

In @CIDJournal, authors describe their institutional experience with C. auris detection via universal screening. https://t.co/81IRz5YswY

[Nature Reviews Microbiology @NatureRevMicro]

New online! Prophylaxis reimagined: innovation where vaccines and antibiotics fall short https://t.co/5Tln4sCQ9H

[MicrobesInfect @MicrobesInfect]

#Pseudoalteromonas sp. H2 Disrupts #Vibrio splendidus Membrane Integrity via ClpP-CheW2 Regulation

https://t.co/0IK2nMJufY #OpenAccess #microbiology

[Cell Host & Microbe @cellhostmicrobe]

UPEC subverts neutrophils

Uropathogenic E coli regulatory system DanRI is induced by nucleosomes present in NETs. DanRI regulates broad cellular responses and dampens neutrophil responses by attenuating reactive oxygen species production & NET formation
https://t.co/ED9lVN4DET

[Nature Reviews Microbiology @NatureRevMicro]

New online! Streptomyces deploys an ancient toxin to feast on insects https://t.co/pYKjStn2SG

[Gang Fang @gangfang_1]

How do bacteria hedge their bets 🎲 in your gut? Our paper is out today in @cellhostmicrobe

A baby received a routine course of amoxicillin. In that infant's #gut 💩, we could see something remarkable, already present **before** the antibiotic arrived: a single strain 🦠 of #Akkermansia muciniphila was already running a quiet experiment. A small subpopulation, 1%, had certain genes switched on that the rest of the population did not. #Importantly, no changes in DNA sequence, yet some genes turned on or off through chemical marks on the DNA. Under antibiotic pressure, that 1% minority expanded and took over. When the antibiotic changed, the population would shift in the opposite direction.

This is #epigenetic #bet-#hedging: bacteria preemptively diversifying into distinct subpopulations so that when uncertain stress comes next, some fraction is already prepared. Our paper presents the first systematic study of this phenomenon across the human gut microbiome, spanning 2,345 metagenomic samples and over 1,300 bacterial species.

#Akkermansia is one of the most studied next-generation probiotics, implicated in metabolic health and cancer immunotherapy response. We were genuinely surprised by its complexity: even within a single strain of Akkermansia, the level of #epigenetic #heterogeneity was striking: many coexisting subpopulations, each with different genes switched on, potentially responding differently to the same environment. Our findings suggest we need to study it at a much deeper level, understanding its #within-strain epigenetic diversity may be key to maximizing its therapeutic potential.

Thanks to #longread #metagenomic sequencing (both #pacbio and #nanopore), which can simultaneously read DNA sequence and methylation at single-molecule resolution. We hope this paper helps make the case for bringing long-read approaches into microbiome research more broadly.

Special 👏 to our first author @Fannimi2001, for his creativity, perseverance and rigor over this entire journey. Science like this does not happen without people who stay committed to a hard problem for the long haul.

Also big thanks to Katerina Junker, @Yujie_L, @fanyu48696214, Yangmei Li, Wanjin Qiao, @Xue_Song__Zhang, @MagdalenaKsi, Edward Mead, @_Alan_T who helped Mi consistently in this journey.

Very much grateful to our collaborators: @lauren282012 at the University of Victoria, @valdi001 at Duke University, Martin Blaser at Rutgers University and my colleague @jiang_wenyan at @SinaiGenetics. This work was truly a team effort!

LINK: https://t.co/8NzOxKYHup

#epigenetics
#microbiome
#antibiotics
#probiotics

[Nature Reviews Microbiology @NatureRevMicro]

New online! Revisiting the life cycle of temperate phages https://t.co/Fbvl9lncuU

[Nature Reviews Microbiology @NatureRevMicro]

New online! Next-generation probiotics: an outlook into current applications and future developments https://t.co/7G8pHTXSoj

[Nature Reviews Microbiology @NatureRevMicro]

New online! Vibrio cholerae defends its way to success https://t.co/tdDPH6kxjt

[Nature Reviews Microbiology @NatureRevMicro]

New online! Concepts of RNA virus evolution for the design of better antiviral countermeasures https://t.co/k62YH8h7F1

[Alí Sebastian Meza @AliSMV7]

Challenges and therapeutic strategies in
nontuberculous mycobacterial infections related to biofilms

https://t.co/dDnejAe3Sc

[Simplify Rx 📱 @simplify_drugs]

Antibiotics against virus 🦠

[Alí Sebastian Meza @AliSMV7]

Overview of novel cefepime-based β-lactam/β-lactamase inhibitor combinations

https://t.co/QlJyOdY4W9