Shom Goel

Lab Head and Medical Oncologist at the University of Melbourne and Peter MacCallum Cancer Centre. Snow Fellow. 2023 ASCO Education Chair.

[Shom Goel @shomgoel]

Delighted to share our new paper, published today in @Nature , led by @AprilCWatt and @AntonioAhnNZ at the @PeterMacCC and The University of Melbourne @uommedia
Paper: https://t.co/eSq2Y8DuSf

[Neil Vasan @NeilVasan]

Comprehensive review article by Sara Hurvitz @fredhutch on state of the art advances in MBC treatment, published in @NEJM. This is also a timely reference for MDs and scientists and to cite in papers, grants, presentations. @SusanGKomen @BCRFcure @ASCO @AACR @PIK3CApathbreak

https://t.co/ggUlrh3GF4

[Shom Goel @shomgoel]

A nice follow-up to our recent @Nature paper (@BarbMarte).

Nature has published a News & Views piece discussing the work: “The secret life of a cell-cycle gatekeeper of cancer.”

Very proud of the team. Interested to hear where these concepts go next.

https://t.co/Rk4UD0oiZB

[The Mark Foundation for Cancer Research @TheMarkFdn]

CDK4/6 inhibitors, a cornerstone treatment for advanced HR+ breast cancer, were thought to work by reactivating Rb, a tumor suppressor that puts the brakes on cancer cell growth. In @Nature, ASPIRE Awardee @ShomGoel shows that isn’t the full story.
https://t.co/6UF5ruWLdt

[Epigenome Technologies Inc. @EpigenomeTech]

Epigenetics Update - Rb-driven transcription limits its tumour-suppressive effects in breast cancer https://t.co/Mib2Ak2ci2

@AprilCWatt/ @AntonioAhnNZ and @shomgoel (@PeterMacCC/ @uommedia) in @Nature

#Epigenetics #pRB #Cancer #BreastCancer

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https://t.co/WmSYDGXnzb

[Shom Goel @shomgoel]

@AriellaHanker Thanks Ariella :) hope you’re well.

[Shom Goel @shomgoel]

@L_Gil22 @PeterMacCC @Nature @AprilCWatt Thank you Leslie!

[April Watt @AprilCWatt]

Excited to share our work, now in @Nature! Delighted to have co-led this study with co-first author @AntonioAhnNZ under the supervision of @shomgoel at @PeterMacCC @PeterMacRes and the University of Melbourne @uommedia

Open access:
https://t.co/RZSj6kEu75

[Shom Goel @shomgoel]

Thank you @PeterMacCC @PeterMacRes. We are very proud to work in one of the world's best cancer research hospitals.

[Peter Mac Cancer Centre @PeterMacCC]

Peter Mac researchers from @shomgoel's lab have uncovered why breast cancer treatment stops working for some patients.

Published in @Nature, the discovery could help develop new treatment combinations that work for longer and improve outcomes.

More: https://t.co/Awks5JLm22

[Shom Goel @shomgoel]

A terrific team effort, and very grateful to everyone who contributed. And many thanks to those who supported this work @SnowMedical @BCRFcure @TheMarkFdn

[Shom Goel @shomgoel]

Delighted to share our new paper, published today in @Nature , led by @AprilCWatt and @AntonioAhnNZ at the @PeterMacCC and The University of Melbourne @uommedia
Paper: https://t.co/eSq2Y8DuSf

[Shom Goel @shomgoel]

This helps explain why CDK4/6 inhibition works so well with endocrine therapy, and may also explain why endocrine resistance mechanisms such as ESR1 mutations can drive resistance to the combination.

[Shom Goel @shomgoel]

Thank you to @BCTrialsANZ for this tremendous honour. It was a pleasure to share the story of our work over the years during my talk, and to reconnect with many friends and colleagues in Brisbane. @PeterMacRes @PeterMacCC @SnowMedical

[Breast Cancer Trials @BCTrialsANZ]

Congratulations to A/Prof @shomgoel on receiving the 2026 Robert Sutherland Award.

This award recognises a Translational Researcher and their achievements and contributions to improved patient outcomes and is open to BCT members and non-members worldwide.

#BCT2026

[Shom Goel @shomgoel]

With thanks to @SnowMedical @BCRFcure @CDMRP @TheMarkFdn @PeterMacCC for your support of our work

[Shom Goel @shomgoel]

Congratulations @AprilCWatt on a great talk at @SABCSSanAntonio. Provided the first real explanation of why CDK4/6 inhibitors and endocrine therapy work together, with major implications for understanding resistance and therapy development.

[Shom Goel @shomgoel]

Congratulations @AprilCWatt on a great talk at @SABCSSanAntonio. Provided the first real explanation of why CDK4/6 inhibitors and endocrine therapy work together, with major implications for understanding resistance and therapy development.

[Shom Goel @shomgoel]

This is very interesting and in a way what could be predicted. Do you think there’s a desire to develop the drugs for this purpose?

[Vijay Sankaran @bloodgenes]

Wow!! 🔥🔥 CDK4/6 inhibition prevents selection of #ClonalHematopoiesis with DNA-damage repair mutations after chemotherapy! Awesome presentation from Irenaeus Chan from @KellyLBolton lab! #ASH25

[Shom Goel @shomgoel]

Five awesome posters on CDK4/6 resistance - single cell RNA-seq, 3D chromatin structure and ATAC-seq, new PDX models, and new targets. Feels like we are making real progress as different groups are converging on similar observations! @SABCS25 @SABCSSanAntonio