Michael Silverman

[Stephen Moore @StephenMoore]

Colorado’s 4.4% flat tax and strict spending limits helped fuel decades of growth.

Democratic Socialists now want to nearly double the top tax rate and drive successful small businesses out.

Call it the California-ization of Colorado. Rocky Mountain high taxes are coming.

[Sean M. Pond @seanmpond]

Two tax questions will be on our Colorado ballot. Here is how I am voting.

I am voting NO on Initiative 195.

Colorado has one income tax rate of 4.4 percent. Initiative 195 would replace it with six different rates. The highest rate would be 8.4 percent.

Supporters say 97 percent of Coloradans would get a tax cut. That is true, but most people would save only a few dollars to a few hundred dollars each year. In return, the state would collect about $2 billion more every year.

This tax would also hit businesses, estates, trusts, and some small business owners. The tax brackets do not change with inflation. That means more people could be pushed into the higher rates over time.

I am voting YES on Initiative 232.

Initiative 232 would keep Colorado’s income tax rate from going above 4.4 percent. It keeps our taxes simple and stops the state from raising the rate without changing the law again.

I will not trade away a permanent taxpayer protection to save a couple hundred dollars today. Colorado does not have a money problem. Colorado has a spending problem.

NO on 195.

YES on 232.

Sean M. Pond

#VoteNoOn195 #VoteYesOn232 #Colorado #TABOR #SeanPond #UNDERestimated

[Adam Gries @adamgries]

🧵 Elon: “Longevity is an extremely solvable problem”

At Vitalist Bay (May 14 - May 17), we’re solving it!

1K+ pioneers, 100+ speakers, 50+ workshops, 40+ activities, 5 critical health tests

Join us to spark dozens of SpaceXs for longevity!

[Michael Silverman @SilvermanTweets]

@Zephyr_hg NEWS

[Michael Silverman @SilvermanTweets]

@dashboardlim LEARN

[Michael Silverman @SilvermanTweets]

@Zephyr_hg NEWS

[Michael Silverman @SilvermanTweets]

@AlpacaAurelius @grok is there any truth to this?

[Michael Silverman @SilvermanTweets]

@davidasinclair What are the best papers supporting this assertion?

[Michael Silverman @SilvermanTweets]

Breakthroughs in regenerating brain tissue would be a huge unlock for meaningfully extending human life. Very exciting!

[ARPA-H @ARPA_H]

NEW: No technology currently exists to repair damaged brain tissue and fully restore lost function. FRONT aims to enable millions with what is considered permanent brain damage to regain lost functions, including motor control, vision, and speech. https://t.co/uaAhiQV7bf

[Nathan S. Cheng thinks you should work on aging. @realNathanCheng]

🧵1/ LBF7 Spain is happening and we're doing something kinda wild:

-We’re gathering the smartest people who want to SOLVE AGING
-going to a longevity resort in the Spanish mountains
-to learn, discuss and ACTUALLY BUILD stuff for 7 days straight

Here’s what we’re cooking 👇

[Michael Silverman @SilvermanTweets]

@Delta the user experience for trying to check regular bags along with car seats is absolutely confounding to both your customers and front of house staff. Literally every other airline has this process figured out. What is going on?

[Michael Silverman @SilvermanTweets]

@foundmyfitness What about cold brew?

[Dr Singularity @Dr_Singularity]

"Age Reversal Technology Will be Available Only For the Rich"

No, it won't. Here's why

There is a persistent myth clinging to the old world - that when the gods of technology descend, only the elite will bask in their gifts. This myth is outdated. It belongs to an era of scarcity, not the exponential age.

Because the tools we are building are not like rare minerals, or Renaissance paintings. They are code. Data. Scalable interventions. Molecular recipes. Once discovered, once optimized, once automated—they can be replicated at marginal cost.

A gene therapy that costs $1 million in 2025 will cost $1,000 in 2030, and perhaps $10 in 2031. The entire infrastructure of biology is being eaten by AI. Automation is devouring cost curves. Robotics, CRISPR, AI driven drug discovery, lab on a chip diagnostics—they are multiplying capacity while dividing cost.

Do you think insulin stayed a luxury? Penicillin? Smartphones? No. Life saving tech always starts expensive—and then it crashes through the floor. That is the arc of technological deflation.

And soon, it will target aging itself.

[Michael Silverman @SilvermanTweets]

Wrote about changing the way we train and mourn as we get older.
https://t.co/5hpdSt2a8D

[Michael Silverman @SilvermanTweets]

@DylGambardella Nothing like getting gains with the fam!

[Michael Silverman @SilvermanTweets]

I used to think longevity would be found in the gym.
Then I joined a longevity fellowship full of people trying to defeat death.
@LBF_org
@realNathanCheng
I wrote about the journey—from fitness to radical life extension.

🧬 From fitness to forever:
https://t.co/blQUWuVCT1

[Michael Silverman @SilvermanTweets]

The best healthcare happens before you get sick.
But the big money's all made after.
Show me the incentive, and I'll show you the outcome.

[Michael Silverman @SilvermanTweets]

@SecDuffy Don’t turn traveling with breast milk into a federal investigation

[Andy Galpin, PhD @DrAndyGalpin]

Want to speed up your metabolism?

Here's what science says about boosting your metabolism. There are numerous evidence-based ways that actually work! But… most of what you've heard is wrong. So, let’s clear up the confusion on what’s bogus, what’s real, and what ‘speeding up your metabolism’ really means - and what it does not!

A deep dive into the research with surprising findings:

First: You can't actually "speed up" your metabolism. That's like saying you can make your car drive faster when it's parked.

What you can do is influence how many "miles" your metabolism drives each day.

Here's how it works:

Your Total Daily Energy Expenditure (TDEE) has 4 components:

1. Exercise Activity (EAT): 0-30% of calories
2. Non-Exercise Activity (NEAT): 5-30%
3. Thermal Effect of Food (TEF): 8-15%
4. Resting Metabolic Rate (RMR): 40-80%

The research shows there are both acute (temporary; minutes to hours) and chronic (long-term; days to weeks or months) ways to influence these components. Most of the nonsense in this topic comes from people making claims about things that enhance ‘metabolic rate’ acutely - which as you’ll see, is actually quite easy to do. But this is very deceiving because acute increase often means very little in the long-term, especially for outcomes like fat loss, and they aren’t necessarily increasing your metabolism in the way you think (they ramp up RMR, for a few minutes, but then it goes right back down to normal, or even below baseline). So, it’s quite easy to deceive with legitimate science here.

That said, let's look at what actually works for acute changes, and by how much:

Acute Boosters:

1. Spicy foods (peppers, ginger, chilis, etc.)

- Increases RMR by 3-5%
- Effect lasts 1-2 hours
- Often through capsaicin in chili peppers

2. Cold exposure

- Lowering room temp by few degrees
- Can lead to significant fat loss over time

3. Caffeine

- Increases RMR by 3-11%
- Lasts 1-3 hours
- Also reduces appetite

4. Green tea

- 4-5% RMR increase
- Similar duration to caffeine
- Compounds with caffeine for better results

But here's what's really interesting: The chronic (long-term) changes are what really matter for sustainable results.

Research shows 4 key factors for long-term metabolic enhancement:

1. Quality Sleep

- Poor sleep reduces RMR
- Increases hunger hormones
- Can reduce fat loss by 55%
- Affects muscle preservation

2. Fish Oil (3g/day)

- 14% increase in RMR
- 19% increase in fat oxidation
- 4% increase in lean mass over 12 weeks

3. Muscle Mass

- Each pound burns 6-10 extra calories daily
- Primary factor in age-related metabolic decline
- Explains up to 80% of RMR variance

4. Exercise

- Strength training: +100 cal/day RMR
- Cardio: +50-60 cal/day RMR
- Combined: +75 cal/day RMR

The most effective approach? Combining multiple strategies:

- 200 cal from additional exercise
- Fish oil + green tea (+25-50 cal)
- Protein increase (+45 cal from TEF)
- 15-min daily walk (+100 cal)
- Small calorie reduction (-80 cal)

This approach works because it:

- Doesn't crash your metabolism
- Preserves muscle mass
- Avoids adaptive thermogenesis
- Creates sustainable habits

The key isn't finding one magic solution - it's stacking small, evidence-based changes.

Remember: Your metabolism isn't "fast" or "slow."

It's responding to your daily choices in sleep, nutrition, activity, and muscle mass.

Focus on these factors consistently, and you'll create lasting metabolic health.

[Sasha Shtern @SashainDenver]

Markets will stay irrational longer than investors can stay liquid. Will conservative policy makers stay irrational longer than their constituents can stay alive?
#warondrugs #drugwar #NoWar #endwarondrugs