Simeon R Mihaylov

Molecular Neuroscientist, Postdoctoral Fellow at the Francis Crick Institute working on kinases in neurodevelopment and disease. *all views are my own*

[Simeon R Mihaylov @SimoMihaylov]

It’s been a very interesting day of workshops at HUPO 2025. Now time for the welcome plenary lecture. @hupo_org

[Simeon R Mihaylov @SimoMihaylov]

I am running my first ever half marathon - London Landmarks Half Marathon in April.
I am doing this with the support of Epilepsy Action UK and fundraising for them.
If you would like to contribute to making a difference, please donate on my page:

https://t.co/wouOnQ8DdV

[Epilepsy Research Institute @EpilepsyInst]

📢Introducing the #Onein100 campaign
To coincide with our first anniversary as the Epilepsy Research Institute, we are thrilled to launch our One in 100 campaign to raise awareness and secure vital funding for epilepsy research. Join the mission today: https://t.co/XuPs5GmDC9

[Simeon R Mihaylov @SimoMihaylov]

A fantastic must read! I am really happy to be part of this work by Lin and @jennmndassoc et al!

[Guillaume Hautbergue @GHautbergue]

GRASPS: a simple-to-operate translatome technology reveals omics-hidden disease-associated pathways in TDP-43-related amyotrophic lateral sclerosis https://t.co/jQFO4f4c37

[Joseph Bateman @BatemanLab]

Our new paper modelling #mitochondrial disease in Drosophila is now available. UPR and #ATF4 activation in the brain depends on the severity of mitochondrial complex I loss. https://t.co/n6FgPpBx5Q

[Simeon R Mihaylov @SimoMihaylov]

I am excited to share our latest paper on Cdkl5 and the identification of Cdkl2 as a compensating kinase. Fantastic work by @Marg_Silvestre! Happy to be part of this!

https://t.co/yAs1HUkClq

[Sila Ultanir @SilaUltanir]

Recent publication from our lab showing that CDKL2 phosphorylates CDKL5 substrates in brain. Congratulations to Margaux!

https://t.co/5jYbSOiFr4

@TheCrick https://t.co/2KlaHYD7XW

[Simeon R Mihaylov @SimoMihaylov]

@framattedi @alessio_vagnoni @KingsIoPPN Big congrats! Well deserved!

[Simeon R Mihaylov @SimoMihaylov]

@joadelas @LMCB_UCL Fantastic news!!! Congrats Joaquina!

[Joaquina Delas @joadelas]

I am excited to share that I will be starting my lab at UCL as part of the LMCB @LMCB_UCL in 2024. We will be studying how cis-regulatory elements controls cell fate decisions during development. We are recruiting at all levels. Learn more and reach out!

[The Francis Crick Institute @TheCrick]

Researchers at the Crick, @UCL and @MSDintheUK have identified a potential treatment target for a rare genetic type of childhood epilepsy.

Read more about the study from Marisol Sampedro-Castaneda and @SilaUltanir 👇
https://t.co/UpOd9ciIgP

[Simeon R Mihaylov @SimoMihaylov]

Really happy to be part of this amazing #research done by Marisol Sampedro Castaneda et al. We identified an exciting new substrate of the epilepsy-linked kinase CDKL5 - Cav2.3 and characterised the effect of phosphorylation on its function.
@NatureComms

https://t.co/shDvhLutXv

[Simeon R Mihaylov @SimoMihaylov]

Really happy to be part of this fantastic work by @rebecca_morr et al on LRRK2 in macrophages!

[Max Gutierrez @maxgabgut]

💥Latest preprint on #LRRK2. Fantastic work of @rebecca_morr in the lab with @enricapel and many others. A link between LRRK2 G2019S mutation and cell death in macrophages after membrane damage. Great collaboration with @SilaUltanir @SimoMihaylov @TheCrick https://t.co/LI7QGLUnEG

[Simeon R Mihaylov @SimoMihaylov]

@BatemanLab Thanks Joe! So happy this is out!

[Simeon R Mihaylov @SimoMihaylov]

I am thrilled to announce that our paper on identifying a new function of the master energy homeostasis regulator PGC-1a is out in Nature Comms! Such a fantastic effort by all people involved! @LydiaCastelli @GHautbergue @RNABioLab @HeatherMortiboy

https://t.co/0K9m531O9k

[Joseph Bateman @BatemanLab]

We have an RA post available to work in our new mTOR Pathway Diseases node, part of the NIHR/MRC UK Rare Disease Research Platform. Deadline in 2 weeks. Please RT! @KingsIoPPN

[Joseph Bateman @BatemanLab]

Working with ERUK and other rare disease charities is a major aim for our rare disease node, so looking forward to this exciting project!

[Simeon R Mihaylov @SimoMihaylov]

Taking a little break from science 🇲🇽

[Sergiu P. Pasca @Sergiu_P_Pasca]

How do we go about generating neural cell types in vitro from human pluripotent stem cells?

Generally, we leverage relevant morphogen pathways and iteratively modulate them by trial and error to generate a cell population of interest. This is tedious and we yet have to learn how to derive many disease-relevant cell types.

In an effort spearheaded by the amazing @neal_amin & @kevinwkelley we took a first-level, systematic approach to address this question by building an arrayed screen of morphogen in organoids combined with multiplexed single cell transcriptomics.

We discovered that this platform can generate considerable regional and cell type diversity across the human neural axis and it provided insights into the specification of interesting neuronal populations of the forebrain or cerebellum.

See the results in the preprint below 👇

https://t.co/CtxBzTu0iv

[ITV News Calendar @itvcalendar]

Scientists at the University of Sheffield believe they are a step closer to developing a nasal spray to treat motor neurone disease and some forms of dementia. https://t.co/7wqg5BDfMJ