Francesca Mattedi

Postdoc @UCLIoN @FrattaLab. @KingsIoPPN alumna. Among the many things, interested in axonal biology, intracellular trafficking and local translation in neurons.

[Dementia Researcher @demrescommunity]

Thinking of applying for a PhD? Dr Clíona Farrell’s blog gives practical advice on navigating the competitive world of PhD research applications. 📝🌍 #PhDApplications @ClionaFarrell_

Check back later in the week for two more in this PhD series.

https://t.co/hBybH83Bpo

[Francesca Mattedi @framattedi]

New paper from the lab out in @ScienceMagazine - take a look to find out how cryptic splicing can be exploited to develop novel therapies for ALS.
Very exciting work led by @OscarWilkins16, it’s been great to be a part of it!

[Oscar Wilkins @OscarWilkins16]

Our paper on cryptic splicing-controlled protein expression, which we hope will inspire safer and more adventurous gene therapy approaches for ALS and FTD, has been published in @ScienceMagazine https://t.co/YriG3I4ILF

[arianna tucci @arianna_tucci]

#RepeatExpansionDisorders are up to three times more common than current estimates. Underdiagnosis or reduced penetrance?
by our wonderful dream team @kriski_ibanez @mattzano @chrsclrksn + Bharati Jadhav & Andy Sharp
https://t.co/wyyE2cbZw2

[Under the lab coat @underlabcoat]

🎙 💥 New episode 💥
Meet @NicolBirsa, neuroscientist at @ucl and discover her research, her studies, her hobbies and why she decided to be a researcher!

🎧Listen (and suscribe)
on audio platforms https://t.co/32PKeDnAQY
or Youtube https://t.co/3ow1NhhN9L

[Annalucia Darbey @AnnaluciaDarbey]

Muscles 💪 and AAV 🦠 - what more could you ask for?

Our preprint highlighting strategies for effective transduction of skeletal muscle with AAV with @wenanlan @J_N_Slayer @FrattaLab :

https://t.co/BgdKC1g1Jt

@UCLIoN @UCLBrainScience @UCLDivofSurgery @TheCrick @UKDRI

[Clíona Farrell @ClionaFarrell_]

In this latest blog I discuss the progress in the Alzheimer's disease and Down syndrome field from the recent @t21rs conference in June!

Read or listen below!

[FrattaLab @FrattaLab]

We find TDP-43 loss to cause presynaptic defects, which are rescued by ASOs correcting a single cryptic exon in UNC13A.
Surprising effect of just one cryptic exon and promising strategy for ALS!
Matt Keuss @PeteHarley95 in great collaboration with @jbneuro
https://t.co/zEOUW0kkJb

[Francesca Mattedi @framattedi]

Excited to share our latest paper, now out on @AgingCell

Great collaboration @KingsIoPPN @alessio_vagnoni @themitoboosh @sandysrsr @UCLIoN @J_N_Slayer @SchiavoMNPlab

[Alex Fellows @AlexFellows1]

Calling all neuronal cell biologists. We’re back! 🚨Registration is open for the second #NeurobioUK meeting in York. Any area of neuronal biology welcome. This year we have the amazing Professor Corinne Houart @CorinneHouart @HouartLab as our keynote.
https://t.co/62BzTWD1rP

[Andrew Tosolini @AndrewTosolini]

Delighted to post our pre-print on in vivo #axonaltransport at the #NodeofRanvier. Wonderful collaboration @SchiavoMNPlab @J_N_Slayer @samuscientist

[Alessio Vagnoni - now @alessiovagnoni.bsky.social @alessio_vagnoni]

Expanding our reach a little, thanks @HorizonEU @_MIA_Portugal @UnivdeCoimbra @KingsCollegeLon
Recruiting:
-3 postdocs and 1 tech/lab manager to join the newly established Fly Coimbra Lab (FlyCab) @_MIA_Portugal
-1 RA @KingsIoPPN soon to be advertised. Get in touch if interested!

[Dementia Researcher @demrescommunity]

All this week we've been at the @adpdnet conference. Our next podcast will be a two part special bringing you news from the event. We're delighted to introduce Dr Ariana Gatt @ariana_gatt who will be joining us to share her highlights.

https://t.co/kWiishNsjO

[Joseph Bateman @BatemanLab]

Our new paper modelling #mitochondrial disease in Drosophila is now available. UPR and #ATF4 activation in the brain depends on the severity of mitochondrial complex I loss. https://t.co/n6FgPpBx5Q

[Ruepp Lab @RueppLab]

Do you love #RNA and #neuroscience? Are you looking for a #postdocposition on #ALS and gene therapy? Join @RueppLab @UKDRI @KingsIoPPN and @FrattaLab @UCLIoN for a collaborative pre-clinical project on a novel gene therapy approach for ALS. More info here: https://t.co/XQBRwcgyh4

[FrattaLab @FrattaLab]

TDP-43 loss causes mis-splicing in ALS/FTD. We now show it also induces widespread cryptic 3'UTRs. This increases RNA stability, translation and function of ELK1 and other TFs. Also provides novel targets for biomarker and therapeutics development.
https://t.co/vX85W0FDeK

[Francesca Mattedi @framattedi]

@ClionaFarrell_ @alessio_vagnoni @KingsIoPPN Thanks 😊

[Francesca Mattedi @framattedi]

I’m truly honoured to have been awarded the 2022 Tadion Rideal Prize! Thank you to my PhD supervisor @alessio_vagnoni for his mentorship (and for nominating me) - I’ve really enjoyed my time at King’s! @KingsIoPPN

https://t.co/G00RF6E6Ts

[Francesca Mattedi @framattedi]

@SimoMihaylov @alessio_vagnoni @KingsIoPPN Thanks Simo!

[Francesca Mattedi @framattedi]

@ariana_gatt @alessio_vagnoni @KingsIoPPN Thank you 😊